J&J's Tecvayli recommended by NICE to treat relapsed and refractory multiple myeloma

22 Jul 2024
Drug ApprovalClinical Result
Johnson & Johnson’s (J&J) Tecvayli (teclistamab) has been recommended by the National Institute for Health and Care Excellence (NICE) to treat adults in England and Wales with relapsed and refractory multiple myeloma (RRMM).
Approximately 5,900 people are diagnosed in the UK every year with multiple myeloma, an incurable blood cancer that affects a type of white blood cell called plasma cells.pomalidomidedexamethasone
The majority of patients will relapse and require subsequent therapmultiple myeloma declining afteblood cancerof treatment.
Administered as a subcutaneous injection, Tecvayli is a bispecific antibody that works by redirecting T cells to multiple myeloma cells and helping to destroy them.
NICE’s decision was supported by clinical Tecvaylisults showing that RRMM patients who received Tecvayli after thmultiple myelomaies had a median overall survival of 22 months and a median progression-free survival of 11 months.
Further data comparing Tecvayli to pom-dex demonstrated that J&J’s thRRMMy reduces the risk of dTecvaylirogression by 44% and the risk of death by 48%.
Amanda Cunnington, seniTecvaylitor of patient access, J&J InnJ&Jtive Medicine UK, said: “Patients with multiple myeloma face several challenges – not least coping with recurrent relapses – and it’s vital that they can access novel treatment options that offer the potential for sustained remission and improved quality of life.”
Cunnington added that, while the draft guidance “meets the needs” of the majority of these patients, thmultiple myelomary concerned” that the proposed restriction applied by NICE removes this option from those who have been waiting for Tecvayli to become available on the NHS.
The recommendation comes just over two weeks after J&J received approvals from both the European Commission (EC) and the US Food and Drug Administration for its tuberculosis treatment, Sirturo (bedaquiline).Tecvayli
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