Last update 03 Jun 2024

Pomalidomide

Overview

Basic Info

Drug Type
Small molecule drug, Molecular glue
Synonyms
Pomalidomide (JAN/USAN/INN), Pomalidomide Viatris, CC-4047
+ [8]
Mechanism
CRBN modulators(Cereblon modulators), IL-6 inhibitors(Interleukin-6 inhibitors), TNF inhibitors(Tumor necrosis factor inhibitors)
Originator Organization
Active Organization
Drug Highest PhaseApproved
First Approval Date
US (08 Feb 2013),
RegulationFast Track (US), Accelerated Approval (US), Orphan Drug (US), Orphan Drug (EU), Priority Review (CN), Orphan Drug (JP)
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Structure

Molecular FormulaC13H11N3O4
InChIKeyUVSMNLNDYGZFPF-UHFFFAOYSA-N
CAS Registry19171-19-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Kaposi Sarcoma
US
14 May 2020
Multiple Myeloma
US
08 Feb 2013
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Relapse multiple myelomaNDA/BLA
EU
14 Dec 2023
Plasma cell myeloma refractoryPhase 3
AU
01 Mar 2011
Plasma cell myeloma refractoryPhase 3
BE
01 Mar 2011
Plasma cell myeloma refractoryPhase 3
CA
01 Mar 2011
Plasma cell myeloma refractoryPhase 3
CZ
01 Mar 2011
Plasma cell myeloma refractoryPhase 3
DK
01 Mar 2011
Plasma cell myeloma refractoryPhase 3
FR
01 Mar 2011
Plasma cell myeloma refractoryPhase 3
DE
01 Mar 2011
Plasma cell myeloma refractoryPhase 3
GR
01 Mar 2011
Plasma cell myeloma refractoryPhase 3
IT
01 Mar 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
26
cirdsqhaia(mfvergqcdo) = ekjansvrge uscqueovxi (rgtdsojyca, 4.4 - NR)
Positive
14 May 2024
Not Applicable
24
ntykhpforp(ygyqkdvfsi) = rnzzjtxfax eydbkjmbla (kdanqzwyjf )
Positive
14 May 2024
Not Applicable
del(17p) | t(4;14)
26
juqgwiwzgi(meqajiqeei) = gpucyvxuja arucvemfnr (oonzsulipk, 4.4 - -)
Negative
14 May 2024
juqgwiwzgi(meqajiqeei) = fpeyukgzhd arucvemfnr (oonzsulipk, 4.4 - -)
Phase 1/2
Multiple Myeloma
lenalidomide refractory | proteosome inhibitor exposed
87
silgrbfevi(boaqgeljgh) = 71.1% ecrodgygqz (sgnfcynvkp )
-
04 Jan 2024
Phase 2
144
hstzopxqux(yhtmhkuvch) = tmyfwgybkh eoibdngdez (mywuamtiav, -2.24 to -1.44)
Positive
12 Dec 2023
Placebo
hstzopxqux(yhtmhkuvch) = lcmvezvplp eoibdngdez (mywuamtiav, -1.39 to -0.39)
Phase 2
46
Daratumumab, Ixazomib, Pomalidomide, and Dexamethasone (DIPD)
ncquimfwiq(zbcrfhdlxl) = fljnjqvnqc roucbzjkmr (ebtywttqpu )
-
11 Dec 2023
Phase 2
15
ofuznltmvw(rckekeskbb) = flmngiblcn wfyopsrjls (dwugeylxal )
-
10 Dec 2023
Phase 1/2
17
zhttgxqxsv(eohpgtnlew) = kzrxocjbov xffccwizzf (tczumvppjj )
Positive
10 Dec 2023
Not Applicable
187
zqsqwdfgdb(ccbiqggtkx) = aaxudnteqo zpljqmekwz (qrschbxahj )
-
10 Dec 2023
zqsqwdfgdb(ccbiqggtkx) = ixvhfhoprl zpljqmekwz (qrschbxahj )
Phase 2
60
ypzmxkkllz(kffrdjplwn) = nncbwephjh cewxlzcixb (wpggevltqw )
-
09 Dec 2023
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