Nimbus Therapeutics shared a snapshot of data from a Phase I/II trial of NDI-101150 that demonstrated the HPK1 inhibitorHPK1 inhibitor led to stable disease or better in six of eight patients with renal cell carcinoma (RCC) who received the oral small molecule. The study results were released ahead of presentation at the American Society of Clinical Oncology (ASCO) annual meeting.
Overall, five of 30 evaluable patients (16.7%) who received NDI-101150 showed a clinical benefit. In the dose escalation cohort, one patient with RCC had a complete response, while a second RCC patient exhibited a partial response. Both were pre-treated with multiple lines of therapies, including checkpoint inhibitors.
Additionally, three patients with RCC, pancreatic cancer, and endometrial cancer, respectively, maintained durable stable disease for more than six months while on treatment; the patient with RCC sustained the response for 21 months.
Nimbus said the HPK1 inhibitorHPK1 inhibitor was well tolerated with an acceptable safety profile.
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