The researchers established venetoclax at a dose of 800 mg as the recommended phase 2 dose. All patients in phase 2 had toxic effects, including grade 3 or 4 neutropenia, thrombocytopenia, anemia, and febrile neutropenia (in 24, 23, 7 and 1 percent of the cycles, respectively). Overall, 54 percent of the evaluable patients with DLBCL had objective responses; complete responses occurred in 38 percent, which were exclusively in patients with non-GCB DLBCL and high-grade B-cell lymphoma with rearrangements of MYC and BCL2 or BCL6 (or both). At the end of ViPOR therapy, circulating tumor DNA was undetectable in 33 percent of the patients. Two-year progression-free and overall survival were 34 and 36 percent, respectively, with a median follow-up of 40 months.
"Although the efficacy of ViPOR in specific molecular subtypes limited the subgroup of patients with DLBCL who had potentially curable disease, this very specificity provides some confidence in the generalizability of our results," the authors write.
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