WEDNESDAY, June 26, 2024 -- Tirzepatide reduces the apnea-hypopnea index (AHI) among individuals with moderate-to-severe obstructive sleep apnea and obesity, according to a study published online June 21 in the New England Journal of Medicine to coincide with the annual meeting of the American Diabetes Association, held from June 21 to 24 in Orlando, Florida.
Atul Malhotra, M.D., from the University of California in San Diego, and colleagues conducted two phase 3 trials involving adults with moderate-to-severe obstructive sleep apnea and obesity. Trial 1 enrolled participants who were not receiving treatment with positive airway pressure (PAP) at baseline, while trial 2 enrolled those who were receiving PAP therapy at baseline. In both trials, participants were randomly assigned to receive 52 weeks of the maximum tolerated dose of tirzepatide (10 or 15 mg) or placebo.
The researchers found that in trial 1, the mean change in AHI was −25.3 and −5.3 events per hour with tirzepatide and placebo, respectively, at week 52 (estimated treatment difference, −20.0 events per hour). In trial 2, the corresponding mean change in AHI was −29.3 and −5.5 events per hour (estimated treatment difference, −23.8 events per hour). For all prespecified key secondary end points, significant improvements were observed with tirzepatide.
The content of the article does not represent any opinions of Synapse and its affiliated companies. If there is any copyright infringement or error, please contact us, and we will deal with it within 24 hours.
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Leverages most recent intelligence information, enabling fullest potential.