A Single-center, Open, Randomized, Single-dose, Cross-over Bioequivalence Study to Evaluate the Effects of the Test Formulation Abalparatide Injection and the Reference Formulation Abalparatide Injection (Tymlos®) in Healthy Adult Subjects

To investigate the pharmacokinetics of the test preparation abalparatide injection and the reference preparation abalparatide injection (Tymlos®) in healthy adult subjects under fasting state, and to evaluate the bioequivalence of the two formulations under fasting state.

Start Date02 Jan 2025

Sponsor / Collaborator

The Affiliated Hospital of Qingdao University

ChiCTR2400094400

/ SuspendedNot ApplicableIIT

Comparing the application value of video files of personalized virtual simulation surgery, 3D visualization and 2D CT in the surgical evaluation of difficult pediatric liver tumors: an observational study

Start Date01 Jan 2025

Sponsor / Collaborator

The Affiliated Hospital of Qingdao University

ChiCTR2400094871

/ SuspendedPhase 4IIT

Efficacy and safety of remazolam toluene sulfonate in sedation of ECMO patients

Start Date01 Jan 2025

Sponsor / Collaborator

The Affiliated Hospital of Qingdao University

100 Clinical Results associated with The Affiliated Hospital of Qingdao University

0 Patents (Medical) associated with The Affiliated Hospital of Qingdao University

3,669

Literatures (Medical) associated with The Affiliated Hospital of Qingdao University

31 Dec 2025·The Journal of Maternal-Fetal & Neonatal Medicine

An integrative approach to identifying NPC1 as a susceptibility gene for gestational diabetes mellitus

Article

Author: Hu, Hong ; Shan, Yuping ; Zhao, Wendi ; Yang, Anning ; Chu, Yijing

OBJECTIVEThe objective of this study was to identify a novel gene and its potential mechanisms associated with susceptibility to gestational diabetes mellitus (GDM) through an integrative approach.METHODSWe analyzed data from genome-wide association studies (GWAS) of GDM in the FinnGen R11 dataset (16,802 GDM cases and 237,816 controls) and Genotype Tissue Expression v8 expression quantitative trait locus data. We used summary-data-based Mendelian randomization to determine associations between transcript levels and phenotypes, transcriptome-wide association studies to provide insights into gene-trait associations, multi-marker analysis of genomic annotation to perform gene-based analysis, genome-wide complex trait analysis-multivariate set-based association test-combo to determine gene prioritization, and polygenic priority scores to prioritize the causal genes to screen candidate genes. Subsequent Mendelian randomization analysis was performed to infer causality between the candidate genes and GDM and phenome-wide association study (PheWAS) analysis was used to explore the associations between selected genes and other characteristics. Furthermore, to gain a deeper understanding of the functional implications of these susceptibility genes, GeneMANIA analysis was used to determine the fundamental biological functions of the therapeutic targets and protein-protein interaction network analysis was performed to identify intracellular protein interactions.RESULTSWe identified two novel susceptibility genes associated with GDM: NPC1 and KIAA1191. Magnetic resonance imaging revealed a strong correlation between NPC1 expression levels and a lower incidence of GDM (odds ratio: 0.922, 95% confidence interval: 0.866-0.981, p = 0.011). PheWAS at the gene level indicated that NPC1 was not associated with any other trait. The biological significance of this gene was evidenced by its strong association with sterol metabolism.CONCLUSIONOur study identified NPC1 as a novel gene whose predicted expression level is linked to a reduced risk of GDM, providing new insights into the genetic framework of this disease.

01 Dec 2025·Inflammation Research

Lysine acetylation and its role in the pathophysiology of acute pancreatitis

Review

Author: Li, Xiaoqian ; Jinfeng, Zhang ; Zhang, Bei ; Yu, Tao ; Li, Xiaolu ; Yang, Yanyan

Acute pancreatitis (AP) represents a severe inflammatory condition of the exocrine pancreas, precipitating systemic organ dysfunction and potential failure. The global prevalence of acute pancreatitis is on an ascending trajectory. The condition carries a significant mortality rate during acute episodes. This underscores the imperative to elucidate the etiopathogenic pathways of acute pancreatitis, enhance comprehension of the disease's intricacies, and identify precise molecular targets coupled with efficacious therapeutic interventions. The pathobiology of acute pancreatitis encompasses not only the ectopic activation of trypsinogen but also extends to disturbances in calcium homeostasis, mitochondrial impairment, autophagic disruption, and endoplasmic reticulum stress responses. Notably, the realm of epigenetic regulation has garnered extensive attention and rigorous investigation in acute pancreatitis research over recent years. One of these modifications, lysine acetylation, is a reversible post-translational modification of proteins that affects enzyme activity, DNA binding, and protein stability by changing the charge on lysine residues and altering protein structure. Numerous studies have revealed the importance of acetylation modification in acute pancreatitis, and that it is a favorable target for the design of new drugs for this disease. This review centers on lysine acetylation, examining the strides made in acute pancreatitis research with a focus on the contributory role of acetylomic alterations in the pathophysiological landscape of acute pancreatitis, thereby aiming to delineate novel therapeutic targets and advance the development of more efficacious treatment modalities.

01 Aug 2025·Neural Regeneration Research

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

Article

Author: Wang, Yin ; Li, Jing ; Zhu, Hai ; Wang, Dong ; Li, Peifeng ; Li, Ruizhi ; Zheng, Yu ; Ma, Lei ; Mu, Jie ; Yin, Lin ; Xu, Yalan ; Leng, Yu

JOURNAL/nrgr/04.03/01300535-202508000-00031/figure1/v/2024-09-30T120553Z/r/image-tiff The protein connector enhancer of kinase suppressor of Ras 2 (CNKSR2), present in both the postsynaptic density and cytoplasm of neurons, is a scaffolding protein with several protein-binding domains. Variants of the CNKSR2 gene have been implicated in neurodevelopmental disorders, particularly intellectual disability, although the precise mechanism involved has not yet been fully understood. Research has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane, thereby influencing synaptic signaling and the morphogenesis of dendritic spines. However, the function of CNKSR2 in the cytoplasm remains to be elucidated. In this study, we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of CNKSR2. Through a combination of bioinformatic analysis and cytological experiments, we found that the CNKSR2 interactors were significantly enriched in the proteome of the centrosome. We also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker CEP290. Subsequent colocalization analysis confirmed the centrosomal localization of CNKSR2. When we downregulated CNKSR2 expression in mouse neuroblastoma cells (Neuro 2A), we observed significant changes in the expression of numerous centrosomal genes. This manipulation also affected centrosome-related functions, including cell size and shape, cell proliferation, and motility. Furthermore, we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum disorder. Our findings establish a connection between CNKSR2 and the centrosome, and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

100 Deals associated with The Affiliated Hospital of Qingdao University

100 Translational Medicine associated with The Affiliated Hospital of Qingdao University

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Drug(Targets)	Indications	Global Highest Phase

XKDCT-080	Colonic Cancer More	Clinical
iPD-1-Claudin18.2-CAR-T(The Affiliated Hospital of Qingdao University) ( CLDN18.2 )	-	Clinical
Low-molecular-weight heparin	Inflammatory Bowel Diseases More	Preclinical
Alginate oligosaccharides ( Nrf2 )	disorder of aging More	Preclinical
Examorelin ( GHSR x SFN )	Acute Kidney Injury More	Preclinical

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