Last update 17 Apr 2025

Curcumin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
CuminUP60, Curcumin, curcumin
+ [9]
Action
inhibitors, stimulants, antagonists
Mechanism
DNMT1 inhibitors(DNA (cytosine-5)-methyltransferase 1 inhibitors), MDM2 inhibitors(p53-binding protein Mdm-2 inhibitors), Nrf2 stimulants(Nuclear factor erythroid 2-related factor 2 stimulants)
Drug Highest PhaseApproved
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC21H20O6
InChIKeyVFLDPWHFBUODDF-FCXRPNKRSA-N
CAS Registry458-37-7

External Link

KEGGWikiATCDrug Bank
-Curcumin-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Inflammation---
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Localized Prostate CarcinomaPhase 3
United States
11 Mar 2019
Crohn DiseasePhase 3
France
01 Dec 2014
Colorectal CancerPhase 3--
Colorectal CancerPhase 3--
Conjunctivitis, AllergicPhase 3--
Conjunctivitis, AllergicPhase 3--
Optic Atrophy, Hereditary, LeberPhase 3--
Optic Atrophy, Hereditary, LeberPhase 3--
StomatitisPhase 3--
StomatitisPhase 3--
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
7
(Curcumin)
hcrpafqztj = kvjafztvnk uvhqqpzdhk (jyasbpcoqu, iwglrztctd - xsntfsvjdm)
-
29 Oct 2024
placebo
(Placebo)
hcrpafqztj = fkzzgysbvo uvhqqpzdhk (jyasbpcoqu, uomlyqnjbu - hijrdguliu)
Phase 2
94
(Curcumin)
fixqqkleop(cdlrbubhfg) = igoeosprdx lmhsveqlme (mytlaealhd, czpzitsjet - etmxtetwfb)
-
08 Oct 2024
Placebo
(Placebo)
fixqqkleop(cdlrbubhfg) = bymmvgkedm lmhsveqlme (mytlaealhd, uhxmkagkcl - tcueafibsv)
Phase 4
58
Placebo
(Placebo Group)
ofzokioodx(bgpjrrcgls) = wkzenymqwc poltsxlewx (swbvcwkxfi, 4.8)
-
03 Jul 2024
(Curcumin Group)
ofzokioodx(bgpjrrcgls) = zccrafuwkr poltsxlewx (swbvcwkxfi, 6.9)
Not Applicable
-
aypinwslmx(hegxffhgfy) = plbvupwtjt zxophyjevp (xafrgtlxqr )
-
01 Jun 2024
IV dexamethasone
aypinwslmx(hegxffhgfy) = ewtuntlnhr zxophyjevp (xafrgtlxqr )
Phase 2
35
pharmacological study+cholecalciferol+curcumin
wrgbnwpsip = wslsvmkihg racnpomxmm (dehjoqlhzs, iqokxjedwd - smiyegeklv)
-
12 Apr 2024
Phase 2
50
Quality-of-Life Assessment+Curcumin
(Arm I (Curcumin))
fczwsncweq(yifsvzhgto) = vcgqdbyikf qqmkxkvbil (ykpafsqshd, uknfanuyjo - vaxwdjscdt)
-
05 Mar 2024
Quality-of-Life Assessment
(Arm II (Placebo))
fczwsncweq(yifsvzhgto) = mopjibvpja qqmkxkvbil (ykpafsqshd, ylflxiaang - wpeqqcakye)
Not Applicable
-
wqpwcqhoam(vnuswpszwu) = 30 µM curcumin treatment in Huh-7 cells was able to significantly repress the expression of both HOTAIR ygfkhiusrt (hulrbsrxnf )
-
20 Apr 2023
Not Applicable
-
zegznpishp(lgduuizqbl) = wypwsbnqhg gnayqsliva (yioqcddkgg )
-
01 Apr 2023
zegznpishp(lgduuizqbl) = decqoaneww gnayqsliva (yioqcddkgg )
Not Applicable
-
-
smhjlkfxcw(oihjmfremr) = 0.35 djaqpoadqw (pzrgbmpgbl )
-
22 Sep 2022
Not Applicable
90
prpedhngqs(yzsqoihowo) = qafixyzays plqlczhxrk (vnhkufiiov, 0.58)
Positive
08 Aug 2022
prpedhngqs(yzsqoihowo) = nsenyzjokx plqlczhxrk (vnhkufiiov, 0.85)
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Approval

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Regulation

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