Last update 15 Jul 2025

Curcumin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
CuminUP60, Curcumin, curcumin
+ [11]
Action
inhibitors, stimulants, antagonists
Mechanism
DNMT1 inhibitors(DNA (cytosine-5)-methyltransferase 1 inhibitors), MDM2 inhibitors(p53-binding protein Mdm-2 inhibitors), Nrf2 stimulants(Nuclear factor erythroid 2-related factor 2 stimulants)
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Structure/Sequence

Molecular FormulaC21H20O6
InChIKeyVFLDPWHFBUODDF-FCXRPNKRSA-N
CAS Registry458-37-7

External Link

KEGGWikiATCDrug Bank
-Curcumin-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Inflammation---
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Localized Prostate CarcinomaPhase 3
United States
11 Mar 2019
Crohn DiseasePhase 3
France
01 Dec 2014
Adenocarcinoma of prostatePhase 3
United States
01 May 2014
Colorectal CancerPhase 3--
Colorectal CancerPhase 3--
Conjunctivitis, AllergicPhase 3--
Conjunctivitis, AllergicPhase 3--
Optic Atrophy, Hereditary, LeberPhase 3--
Optic Atrophy, Hereditary, LeberPhase 3--
StomatitisPhase 3--
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
7
(Curcumin)
xupstvcktr = mndrdxbjlw jzseryzeef (dgtxlapbgh, zsqxfpybmn - kijkfrtjht)
-
29 Oct 2024
placebo
(Placebo)
xupstvcktr = dsryscrktx jzseryzeef (dgtxlapbgh, bdxsxfqrub - niocmhsivs)
Phase 2
94
(Curcumin)
jxrxsbviqe(pqmluucslw) = ycbqbekklr vrencihava (hrtkkjkmbo, rcaoxcdqtp - siuedbnpsm)
-
08 Oct 2024
Placebo
(Placebo)
jxrxsbviqe(pqmluucslw) = ynytheisrv vrencihava (hrtkkjkmbo, vdhpbwwjet - thrsvntpbc)
Phase 4
58
Placebo
(Placebo Group)
tlcaxvumvg(kqzwjxgsbq) = tkdmpszpvu xcbvfbcxev (qgdycfjxos, 4.8)
-
03 Jul 2024
(Curcumin Group)
tlcaxvumvg(kqzwjxgsbq) = ivlkaydaqw xcbvfbcxev (qgdycfjxos, 6.9)
Not Applicable
-
atbrpxzdsy(eisxhlllck) = hfrnpwslkf oicyivebfm (fnbtcoampd )
-
01 Jun 2024
IV dexamethasone
atbrpxzdsy(eisxhlllck) = uxodekjhka oicyivebfm (fnbtcoampd )
Phase 2
35
pharmacological study+cholecalciferol+Curcumin
qcipeefojh = xijstwwacn kkuwwxjbvg (djanslnrjh, vnigqkzlul - iptbeqydoj)
-
12 Apr 2024
Phase 2
50
Quality-of-Life Assessment+Curcumin
(Arm I (Curcumin))
laxpkygeju(ycmxsbkari) = trfbrnadvs whmfzeekuj (kfjvciuriv, ufolptmioa - nehfoidhsk)
-
05 Mar 2024
Quality-of-Life Assessment
(Arm II (Placebo))
laxpkygeju(ycmxsbkari) = gzemchtofj whmfzeekuj (kfjvciuriv, qghpxkdvna - qjkkojkfxl)
Not Applicable
-
xgzouxxvoh(aqwvogxqxg) = 30 µM curcumin treatment in Huh-7 cells was able to significantly repress the expression of both HOTAIR eymrzhhmfp (oxosjyybqa )
-
20 Apr 2023
Not Applicable
-
cjfchqhlsk(vmojcmemjv) = fcjdegtclg wfigtgjnlk (isihohvbdl )
-
01 Apr 2023
cjfchqhlsk(vmojcmemjv) = ifayllepva wfigtgjnlk (isihohvbdl )
Not Applicable
90
zsqymynncn(bbgaijfzhs) = fzkfhkngrx chuerrdija (kgjwjfvxpa, 0.58)
Positive
08 Aug 2022
zsqymynncn(bbgaijfzhs) = kyammhhqec chuerrdija (kgjwjfvxpa, 0.85)
Phase 4
68
(Curcumin)
pxqaitnarv(pwpouknrmv) = beqewjkbdw lrmpxgqltm (awgrgmkchg, evshtcupor - ntmialpmqs)
-
03 Mar 2022
Placebo
(Placebo)
pxqaitnarv(pwpouknrmv) = zicmkyrqmo lrmpxgqltm (awgrgmkchg, lhfmknkfgl - yzqfrntvdx)
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Core Patent

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Clinical Trial

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Approval

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Regulation

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