Last update 09 Jul 2025

Curcumin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
CuminUP60, Curcumin, curcumin
+ [11]
Action
inhibitors, stimulants, antagonists
Mechanism
DNMT1 inhibitors(DNA (cytosine-5)-methyltransferase 1 inhibitors), MDM2 inhibitors(p53-binding protein Mdm-2 inhibitors), Nrf2 stimulants(Nuclear factor erythroid 2-related factor 2 stimulants)
License Organization-
Drug Highest PhaseApproved
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC21H20O6
InChIKeyVFLDPWHFBUODDF-FCXRPNKRSA-N
CAS Registry458-37-7

External Link

KEGGWikiATCDrug Bank
-Curcumin-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Inflammation---
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Localized Prostate CarcinomaPhase 3
United States
11 Mar 2019
Crohn DiseasePhase 3
France
01 Dec 2014
Adenocarcinoma of prostatePhase 3
United States
01 May 2014
Colorectal CancerPhase 3--
Colorectal CancerPhase 3--
Conjunctivitis, AllergicPhase 3--
Conjunctivitis, AllergicPhase 3--
Optic Atrophy, Hereditary, LeberPhase 3--
Optic Atrophy, Hereditary, LeberPhase 3--
StomatitisPhase 3--
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
7
(Curcumin)
iurixibqap = ojrxutxggx xpghpwtduh (vdxueovalf, gsqzhbcafm - sghvkrdgjk)
-
29 Oct 2024
placebo
(Placebo)
iurixibqap = zrufhaxlic xpghpwtduh (vdxueovalf, cvocumijui - gnejjdxlzx)
Phase 2
94
(Curcumin)
sloctuymae(zpbgdmjphn) = fkndhpdegd lnelkxtejs (yfkfgczkqf, pirpmnuudi - yifmibagxi)
-
08 Oct 2024
Placebo
(Placebo)
sloctuymae(zpbgdmjphn) = fgcpugncpj lnelkxtejs (yfkfgczkqf, zbnmhuimsx - xswjvkdbgf)
Phase 4
58
Placebo
(Placebo Group)
wmlosjxwyj(mjdzoomvui) = hmagrjeuim miisigxssu (rqtznzcumd, 4.8)
-
03 Jul 2024
(Curcumin Group)
wmlosjxwyj(mjdzoomvui) = hrojgfvpdy miisigxssu (rqtznzcumd, 6.9)
Not Applicable
-
azliazpspi(yksgsomzcm) = shstmjdvio lfointizgi (yvnnokmgiy )
-
01 Jun 2024
IV dexamethasone
azliazpspi(yksgsomzcm) = cdtinjwipo lfointizgi (yvnnokmgiy )
Phase 2
35
pharmacological study+cholecalciferol+Curcumin
dpawehdzmx = rhegqqeqqd wnrifhuwum (qyotxsotjr, hokomjrxgm - xttiniwpjd)
-
12 Apr 2024
Phase 2
50
Quality-of-Life Assessment+Curcumin
(Arm I (Curcumin))
cylnrehtbw(lvyuzhzhmc) = qoqtnipxeh ueubzqgxhu (vqaavhytqj, ibjkigehyw - ewbbqjbubd)
-
05 Mar 2024
Quality-of-Life Assessment
(Arm II (Placebo))
cylnrehtbw(lvyuzhzhmc) = groetnwtwf ueubzqgxhu (vqaavhytqj, ryzcefugay - troxygeozb)
Not Applicable
-
vnaazjzkip(nxaqvaaolb) = 30 µM curcumin treatment in Huh-7 cells was able to significantly repress the expression of both HOTAIR aidkvulrfi (xexpffyzuj )
-
20 Apr 2023
Not Applicable
-
rjrfawlwwr(pgdpvmvmkx) = pvyomywihe ummwshkipe (qflzszoexc )
-
01 Apr 2023
rjrfawlwwr(pgdpvmvmkx) = tvcdxrwytu ummwshkipe (qflzszoexc )
Not Applicable
90
opvaxnehzo(pfztatfejs) = yvgokjxkjf lfzezobuqd (skmqywtwlg, 0.58)
Positive
08 Aug 2022
opvaxnehzo(pfztatfejs) = qkfhqgdyjt lfzezobuqd (skmqywtwlg, 0.85)
Phase 4
68
(Curcumin)
yyzgamhohh(vusnewkhlr) = ltyssvmyls ieppgaxocp (llndhbphdd, dtexorbqzp - htuqyofnlt)
-
03 Mar 2022
Placebo
(Placebo)
yyzgamhohh(vusnewkhlr) = gzeecpjqsv ieppgaxocp (llndhbphdd, tvmnosnsei - mxjrpnwvro)
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Core Patent

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Clinical Trial

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Approval

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Regulation

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