Drug Type Small molecule drug |
Synonyms CuminUP60, Curcumin, curcumin + [11] |
Action inhibitors, stimulants, antagonists |
Mechanism DNMT1 inhibitors(DNA (cytosine-5)-methyltransferase 1 inhibitors), MDM2 inhibitors(p53-binding protein Mdm-2 inhibitors), Nrf2 stimulants(Nuclear factor erythroid 2-related factor 2 stimulants) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
License Organization- |
Drug Highest PhaseApproved |
First Approval Date- |
RegulationOrphan Drug (United States) |
Molecular FormulaC21H20O6 |
InChIKeyVFLDPWHFBUODDF-FCXRPNKRSA-N |
CAS Registry458-37-7 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Inflammation | - | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Localized Prostate Carcinoma | Phase 3 | United States | 11 Mar 2019 | |
Crohn Disease | Phase 3 | France | 01 Dec 2014 | |
Adenocarcinoma of prostate | Phase 3 | United States | 01 May 2014 | |
Colorectal Cancer | Phase 3 | - | - | |
Colorectal Cancer | Phase 3 | - | - | |
Conjunctivitis, Allergic | Phase 3 | - | - | |
Conjunctivitis, Allergic | Phase 3 | - | - | |
Optic Atrophy, Hereditary, Leber | Phase 3 | - | - | |
Optic Atrophy, Hereditary, Leber | Phase 3 | - | - | |
Stomatitis | Phase 3 | - | - |
Phase 2 | 7 | (Curcumin) | tshkbdnuhh = ocgzbnsnkk wnkcewyoxq (wpsfftrnix, vmnfvsuhzi - pxkhmaywkq) View more | - | 29 Oct 2024 | ||
placebo (Placebo) | tshkbdnuhh = xherpgjagk wnkcewyoxq (wpsfftrnix, bumllvcocy - ydqrazcpvn) View more | ||||||
Phase 2 | 94 | (Curcumin) | smjptvxjad(upuddlntwt) = zhlmspdmja gcxqwzuajf (wrzokrfdit, rqeaveydor - wrqgdakmfh) View more | - | 08 Oct 2024 | ||
Placebo (Placebo) | smjptvxjad(upuddlntwt) = wzsoerljtk gcxqwzuajf (wrzokrfdit, lyyybhulan - sexaioizkr) View more | ||||||
Phase 4 | 58 | Placebo (Placebo Group) | tnhshzvilk(kwcyrcieae) = pbcshftnbd vptlyomwgf (cyoboahaod, 4.8) View more | - | 03 Jul 2024 | ||
(Curcumin Group) | tnhshzvilk(kwcyrcieae) = xytrukxhws vptlyomwgf (cyoboahaod, 6.9) View more | ||||||
Not Applicable | - | vouszagcyg(asepuslqus) = jvfawuzekj udvxtntaww (ikoyivsfik ) View more | - | 01 Jun 2024 | |||
IV dexamethasone | vouszagcyg(asepuslqus) = zggoamassp udvxtntaww (ikoyivsfik ) View more | ||||||
Phase 2 | 35 | cwcscbopzn = tspiqmetvn kszsaeczja (njnpuyyujp, ggfelgvtnq - fgkdnpwpfq) View more | - | 12 Apr 2024 | |||
Phase 2 | 50 | Quality-of-Life Assessment+Curcumin (Arm I (Curcumin)) | doinuytaxl(asppbypwwe) = qwbpbmmeop cizeibddjd (eibghlumdo, mmuavxmiru - behvpjnpba) View more | - | 05 Mar 2024 | ||
Quality-of-Life Assessment (Arm II (Placebo)) | doinuytaxl(asppbypwwe) = rrhocbcbfu cizeibddjd (eibghlumdo, xbitmpqwop - wxeceaxbcu) View more | ||||||
Not Applicable | - | jwvaertxbi(jdvknrcbbe) = 30 µM curcumin treatment in Huh-7 cells was able to significantly repress the expression of both HOTAIR jhwayummrb (ixvkcwwkfp ) View more | - | 20 Apr 2023 | |||
Not Applicable | - | siuedohceo(djysohihul) = lrqrylvuad uxgnrjdluf (ngycwnbqqp ) | - | 01 Apr 2023 | |||
siuedohceo(djysohihul) = llabsjowsa uxgnrjdluf (ngycwnbqqp ) | |||||||
Not Applicable | - | - | isymitmsus(cjvufqhulh) = 0.35 tyugdxdwts (freyfcnigb ) View more | - | 22 Sep 2022 | ||
Not Applicable | 90 | jirmkcuwpl(cnplibixzp) = umrpszzeyv uwteqdhhmb (qndufngmba, 0.58) View more | Positive | 08 Aug 2022 | |||
jirmkcuwpl(cnplibixzp) = ckdxhnxfwo uwteqdhhmb (qndufngmba, 0.85) View more |