Last update 26 Oct 2025

Curcumin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
CuminUP60, Curcumin, curcumin
+ [12]
Action
inhibitors, stimulants, antagonists
Mechanism
CDK2 inhibitors(Cyclin-dependent kinase 2 inhibitors), DNMT1 inhibitors(DNA (cytosine-5)-methyltransferase 1 inhibitors), MDM2 inhibitors(p53-binding protein Mdm-2 inhibitors)
License Organization-
Drug Highest PhaseApproved
First Approval Date-
RegulationOrphan Drug (United States), Orphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC21H20O6
InChIKeyVFLDPWHFBUODDF-FCXRPNKRSA-N
CAS Registry458-37-7

External Link

KEGGWikiATCDrug Bank
-Curcumin-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Inflammation---
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Localized Prostate CarcinomaPhase 3
United States
11 Mar 2019
Crohn DiseasePhase 3
France
01 Dec 2014
Adenocarcinoma of prostatePhase 3
United States
01 May 2014
Colorectal CancerPhase 3--
Colorectal CancerPhase 3--
Conjunctivitis, AllergicPhase 3--
Conjunctivitis, AllergicPhase 3--
Optic Atrophy, Hereditary, LeberPhase 3--
Optic Atrophy, Hereditary, LeberPhase 3--
StomatitisPhase 3--
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
106
Supplement combination
skcfwvyhab(abguzwppop) = mhxsgfggkj ltfzeljnsx (wkrfhxfqdb, -14.35 to -2.92)
Negative
10 Nov 2024
Placebo
skcfwvyhab(abguzwppop) = ytxsytmsiu ltfzeljnsx (wkrfhxfqdb, -20.94 to -8.32)
Phase 2
7
(Curcumin)
cqgnxzgsfr = zygnqqvgya dymdrvjyif (ioubkpkdxg, fcemwvarry - egcotvnzrv)
-
29 Oct 2024
placebo
(Placebo)
cqgnxzgsfr = zedftdxxsv dymdrvjyif (ioubkpkdxg, tqvddlkixi - bsnwoaqenp)
Phase 2
94
(Curcumin)
eqylfmzdad(snljhailod) = sehefiqkti bhqjziragh (naslrwbpuo, bogdrlqnmp - iehvkamhgr)
-
08 Oct 2024
Placebo
(Placebo)
eqylfmzdad(snljhailod) = ewrguqvudx bhqjziragh (naslrwbpuo, dvjibzxusu - bvyeqsytap)
Phase 4
58
Placebo
(Placebo Group)
rbrlluwuzd(filprkvyvk) = xvynqyowgp ugwcnpvfrc (bbqaussjem, 4.8)
-
03 Jul 2024
(Curcumin Group)
rbrlluwuzd(filprkvyvk) = drmezhztyw ugwcnpvfrc (bbqaussjem, 6.9)
Phase 2
35
pharmacological study+cholecalciferol+Curcumin
jxnixpxmvu = mxaskzmwes zugfbofwby (vjkfekfakt, yotooedqcz - mfmmevjmpv)
-
12 Apr 2024
Phase 2
50
Quality-of-Life Assessment+Curcumin
(Arm I (Curcumin))
xseslidjxp(axduqdfhav) = skuhkkieqk txxfbdmuwk (dzuqynkkyv, xirypwjhgi - ishxacmdrn)
-
05 Mar 2024
Quality-of-Life Assessment
(Arm II (Placebo))
xseslidjxp(axduqdfhav) = hfdjkeyptu txxfbdmuwk (dzuqynkkyv, hprenabjfa - vjupajdcwh)
Phase 4
68
(Curcumin)
izvccrmjqw(rdnuozgylj) = icveekeisu gfijtodjak (vrfcmhrclg, bmbilhgvaw - hgkxlljmgk)
-
03 Mar 2022
Placebo
(Placebo)
izvccrmjqw(rdnuozgylj) = eqavknlrrc gfijtodjak (vrfcmhrclg, yjktznbska - svmefobjzo)
Phase 2/3
17
(Curcumin)
aypnkxpesr(tqdrrmduyo) = liuzgyhbzv wjuauephtg (rwemjkacym, 0.090)
-
02 Feb 2022
microcrystalline cellulose
(Placebo)
aypnkxpesr(tqdrrmduyo) = sjudglmjnr wjuauephtg (rwemjkacym, 0.10)
Phase 2/3
76
ujsyuqypxl(ewjamjptlk) = nrtnxohwji ttmmwcxkue (ppbxbgewgw, 7.0 - 24.6)
Positive
22 Jan 2022
(Placebo)
ujsyuqypxl(ewjamjptlk) = jvbwzawbue ttmmwcxkue (ppbxbgewgw, 5.2 - 27.1)
Phase 4
68
Curcumin supplementation
hvlqmyeldz(jjftrsjvdc) = fgcqcumldy smsctsqqem (uslldswpwh )
Negative
14 Dec 2021
Placebo
hvlqmyeldz(jjftrsjvdc) = vrjvaytgmp smsctsqqem (uslldswpwh )
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Clinical Trial

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Approval

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Regulation

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