Evaluation of intratumoral expression of chemotherapy-associated biomarkers for postoperative adjuvant chemotherarpy against advanced stage lung cancer - Evaluation of expression of chemotherapy-associated biomarkers

Start Date01 Mar 2020

Sponsor / Collaborator

Kitano Hospital

JPRN-UMIN000021316

/ RecruitingNot ApplicableIIT

Efficacy of EBL for colonic diverticular hemorrhage - Efficacy of EBL for colonic diverticular hemorrhage

Start Date31 Dec 2019

Sponsor / Collaborator

Kitano Hospital

NCT02923817

/ Unknown statusPhase 2IIT

Phase I-II Clinical Trial Using Bone Marrow-derived Mononuclear Cells for Spinal Cord Injury

The purpose of study is to determine whether autologous mononuclear cells deriving from the bone marrow are effective in the treatment of spinal cord injury.

Start Date01 Sep 2016

Sponsor / Collaborator

Da Nang Hospital

[+1]

100 Clinical Results associated with Kitano Hospital

0 Patents (Medical) associated with Kitano Hospital

1,318

Literatures (Medical) associated with Kitano Hospital

01 Jun 2025·Surgical Oncology

Efficacy and safety of polyglycolic acid sheets for prevention of intra-abdominal infectious complications following minimally invasive surgery for gastric cancer: A prospective, multicenter, single-arm clinical trial

Article

Author: Matsuo, Koichi ; Sakaguchi, Masazumi ; Nakanishi, Yasutaka ; Kanaya, Seiichiro ; Yamamoto, Michihiro ; Manaka, Dai ; Hoshino, Nobuaki ; Abe, Hiroyasu ; Toda, Kosuke ; Obama, Kazutaka ; Kondo, Masato ; Kinjo, Yosuke ; Nishigori, Tatsuto ; Hisamori, Shigeo ; Tanaka, Eiji ; Tsunoda, Shigeru ; Hosogi, Hisahiro

BACKGROUNDSerious intra-abdominal infectious complications are common after gastric cancer surgery, including anastomotic leakage, pancreatic fistula, and intra-abdominal abscess. Although polyglycolic acid sheets are often used to reinforce soft tissue and prevent postoperative complications in various types of surgery, including gastric cancer surgery, their effectiveness has not yet been fully demonstrated.METHODSPatients with gastric cancer and no distant metastasis undergoing minimally invasive distal or total gastrectomy at Kyoto University Hospital or its 9 affiliated facilities between March 2022 and December 2023 were enrolled. The primary outcome was incidence of Clavien-Dindo (CD) grade ≥ III intra-abdominal infectious complications, including anastomotic leakage, pancreatic fistula, and intra-abdominal abscess. Secondary outcomes were incidence of overall complications (CD grade ≥ III), pancreatic fistula (CD grade ≥ III), or anastomotic leakage (CD grade ≥ III).RESULTSIn total, 210 patients were included. Distal gastrectomy was performed in 186 cases (88.6 %) and total gastrectomy in 24 (11.4 %). No cases required conversion to laparotomy. The incidence of CD grade III intra-abdominal infectious complications was 1.4 % (90 % confidence interval 0.6-3.5), below the pre-defined limit of 7.0 %. The rate of CD grade ≥ III overall complications was 4.3 %, that of CD grade ≥ III pancreatic fistula was 1.0 %, and that of CD grade ≥ III anastomotic leakage was 0.5 %. The polyglycolic acid sheet was not associated with any serious complications or abnormal laboratory values.CONCLUSIONPolyglycolic acid sheets were safe and effective in preventing serious intra-abdominal infectious complications after minimally invasive surgery for gastric cancer. TRIAL REGISTRY NUMBER: jRCTs052210188.

22 Apr 2025·Proceedings of the National Academy of Sciences

Bidirectional disruption of GNAS transcripts causes broad methylation defects in pseudohypoparathyroidism type 1B

Article

Author: Reyes, Monica ; Salusky, Isidro B. ; Gales, Barbara ; Bastepe, Murat ; Miller, Danny E. ; Linglart, Agnès ; Iwasaki, Yorihiro ; Jüppner, Harald ; Ryabets-Lienhard, Anna

Pseudohypoparathyroidism type 1B (PHP1B) is a multihormone resistance disorder caused by aberrant GNAS methylation. Characteristic epigenetic changes at GNAS differentially methylated regions (DMRs), i.e., NESP, AS1, AS2, XL, and A/B, are associated with specific structural defects in different autosomal dominant PHP1B (AD-PHP1B) subtypes. However, mechanisms underlying abnormal GNAS methylation remain incompletely defined, largely because viable PHP1B mouse models are lacking. Using lymphoblastoid cells and induced pluripotent stem cells, we show that various GNAS methylation patterns in PHP1B reflect differential disruption of sense and antisense GNAS transcripts. In cases with broad GNAS methylation changes, loss of the maternal, sense-transcribed exon H/AS region impairs methylation of the AS1 DMR, which results in biallelic expression of an antisense transcript, GNAS-AS1 , and NESP hypermethylation. In contrast, cases with normal AS1 methylation, including STX16 deletions, show monoallelic GNAS-AS1 expression and normal NESP methylation. The roles of these GNAS transcripts were confirmed by a retrotransposon in GNAS-AS1 intron 1, identified in an AD-PHP1B family. This insertion impaired exon H/AS transcription when located on the maternal allele, thus preventing the complete establishment of methylation at all maternal GNAS DMRs, leading to biallelic GNAS-AS1 transcription. However, maternal GNAS-AS1 transcription was profoundly attenuated, thus allowing only a small gain-of-methylation at NESP. Likewise, on the paternal allele, the retrotransposon attenuated GNAS-AS1 transcription, thus preventing complete NESP methylation. Our findings support a model of bidirectional transcription-mediated regulation of methylation at GNAS DMRs and will help to refine systematic approaches for establishing molecular defects underlying different PHP1B subtypes.

31 Mar 2025·Multimedia Manual of Cardio-Thoracic Surgery

Feasibility of the lung base-flip approach for complex segmentectomy of the lower lobe

Author: Kobayashi, Megumi ; Tanaka, Satona ; Ohsumi, Akihiro ; Date, Hiroshi

Segmentectomies of the lung base, such as S9, S10 or S9+S10, present technical difficulties because they do not connect directly to the interlobar fissure. The lung base-flip approach offers easier access to the individual segmental vessels and bronchi. We performed a segmentectomy of the lung base using this approach. To identify the corresponding vessels and bronchi, flipped three-dimensional chest computed tomography images and intraoperative bronchoscopy are essential.

100 Deals associated with Kitano Hospital

100 Translational Medicine associated with Kitano Hospital

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