Hainan Wanzhou Green Pharmaceutical Co., Ltd

Propranolol hydrochloride drops (specification: 20 mg/mL) provided by Hainan Noen Biotechnology Co., Ltd. were used as the test preparation, and propranolol hydrochloride oral solution (specification: 4.28 mg/mL (equivalent to 3.75 mg propranolol), trade name: HEMANGEOL) from PIERRE FABRE DERMATOLOGIE was used as the reference preparation. The pharmacokinetic parameters and relative bioavailability of the two preparations after single administration in the fasting and postprandial states were investigated to evaluate whether the two preparations were bioequivalent. At the same time, the safety of the two preparations in healthy humans was evaluated, and the palatability of the subjects taking propranolol hydrochloride drops and propranolol hydrochloride oral solution was evaluated and compared.