Delving into the Latest Updates on Nanjing Tongrentang Pharmaceutical Co., Ltd. with Synapse

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Herbal medicine	2

Protein phosphatase 1 (PP1) is a critical regulator of several processes, such as muscle contraction, neuronal signaling, glycogen synthesis, and cell proliferation. Dysregulation of PP1 has recently been found to be implicated in cardiac dysfunctions, which indicates that PP1 could be an attractive therapeutic target. However, discovery of PP1 inhibitors with satisfied safety and efficiency is still a challenge. Here, in order to discover potential PP1 inhibitors, compounds extracted from traditional Chinese medicine (TCM) were screened by a novel integrated virtual screening protocol including pharmacophore modeling and docking approaches. Combined with protein phosphatase inhibition assay, ZINC43060554 showed strongly inhibitory activity with IC₅₀ values of 26.78 μM. Furthermore, molecular dynamics simulation and Molecular Mechanics/Generalized Born Surface Area binding free-energy analysis were performed to examine the stability of ligand binding modes. These novel scaffolds discovered in the present study can be used for rational design of PP1 inhibitors with high affinity.Communicated by Ramaswamy H. Sarma.

Shizhen Guoyi Guoyao

Quality standard for Xuezhiling capsules

Author: An, Jianzhong ; Jiang, Weixin

The quality standard for Xuezhiling Capsules was established.Radix Polygoni multiflori, Fructus crataegi, Semen cassiae were identified by TLC.The content of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside in Radix Polygoni multiflori was determined by HPLC.Spots obtained from the test solutions had the same color in reference solution and medical material in the same location, and the blank solution had no interference.The linear range of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside was from 0 to 0.82 μg (r=0.9999), the average recovery was 97.4% with RSD of 0.45%.In TLC, the spots were very clear and specific to identify the herbal medicine in Xuezhiling Capsules.It was simple, quick, highly precise and accurate for HPLC to control the quality of Xuezhiling Capsules.

100 Deals associated with Nanjing Tongrentang Pharmaceutical Co., Ltd.

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100 Translational Medicine associated with Nanjing Tongrentang Pharmaceutical Co., Ltd.

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Pipeline

Pipeline Snapshot as of 18 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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