Hainan Yishun Pharmaceutical Co. Ltd.

To evaluate the efficacy and safety of dexamethasone palmitate injection in the treatment of rheumatoid arthritis using imported dexamethasone palmitate injection (Limedason) as a control substance.

The pharmacokinetic characteristics of ceftriaxone sodium for injection in healthy Chinese subjects were investigated by single constant-rate intravenous infusion of low, medium and high doses of ceftriaxone sodium for injection in healthy volunteers. Combined with the results of in vitro antibacterial activity assay, a PK/PD study of ceftriaxone sodium for injection was conducted to provide a basis for formulating the medication regimen for Phase II clinical trials.

To observe the safety and tolerability of single and multiple administrations of ceftriaxone sodium for injection in healthy humans, evaluate the safe dosage range of single and multiple administrations of ceftriaxone sodium for injection in healthy humans, determine the maximum tolerated dose of single and multiple administrations in healthy humans, and provide a basis for formulating the dosing regimen for Phase I pharmacokinetic studies and Phase II clinical trials.