Comparing the Effect of Core Stability Exercise with and without the use of Virtual Reality System on Pain, Physical Function and Muscle activity in Athletes with non-Specific Chronic Low Back Pain : A Randomized Controlled Clinical Trial

Start Date05 Dec 2024

Sponsor / Collaborator

Shahid Beheshti University

IRCT20180414039299N2

/ CompletedNot ApplicableIIT

The Effect of 12 week corrective exercises on radiological indices of lower limb alignment, Proprioception and Balance in Patients with Osteoarthritis with Varus Knee Deformity

Start Date22 Oct 2024

Sponsor / Collaborator

Shahid Beheshti University

NCT06625372

/ RecruitingNot ApplicableIIT

Comparison of the Effect of Intralipid Parenteral Nutritional With SMOF Lipid Parenteral Nutritional on Biochemical Markers, Hematologic Markers, and Clinical Outcomes Following Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)

The goal of this clinical trial is to have a successful engraftment in after bone transplantation. Acute leukemia patient of both sexes aged 2 to 18 years, who are transplant candidates, participate in this study. Primary hypothesis is Patients receiving SMOF LIPID will have better grafts than patients receiving intralipid. Also, complications after surgery and malnutrition will be less in this group.

Start Date12 Oct 2024

Sponsor / Collaborator

Shahid Beheshti University

100 Clinical Results associated with Shahid Beheshti University

0 Patents (Medical) associated with Shahid Beheshti University

25,167

Literatures (Medical) associated with Shahid Beheshti University

01 Dec 2025·Molecular Genetics and Genomics

Identification of shared pathogenic signatures of multiple sclerosis and chronic obstructive pulmonary disease: an integrated transcriptomic analysis of blood specimens

Article

Author: Mokaram Doust Delkhah, Arman

Patients with multiple sclerosis (MS) face a heightened risk of developing chronic obstructive pulmonary disease (COPD). Despite this widely reported association, the pathogenic contributors and processes that may favor the development of COPD in MS patients have yet to be identified. Recent studies have suggested peripheral blood leukocytes as a potential link between COPD and autoimmune disorders. Therefore, this study aimed to unveil shared molecular signatures between MS and COPD using blood transcriptomes. To this end, gene expression datasets obtained from MS and COPD blood specimens were retrieved from the Gene Expression Omnibus (GEO) database. By integrating datasets belonging to each disorder, differentially expressed genes (DEGs) were determined for each disease. Then, the protein-protein interaction (PPI) network was constructed for shared DEGs between MS and COPD. Subsequently, the network was analyzed to identify hub genes and key regulatory miRNAs. The integrated data for MS encompassed 51 samples (28 from MS patients and 23 from controls), and the integrated data for COPD included 450 samples (275 from COPD patients and 175 from controls). A total of 246 genes were found to exhibit identical directions of expression in both MS and COPD. By applying a high confidence threshold (0.7), a PPI network with 74 nodes was constructed. TP53, H4C6, SNRPE, and RPS11 were identified as hub genes according to the degree measure. In addition, 8 miRNAs were identified as key regulators, each interacting with 6 mRNAs. Among these miRNAs, miR-218-5p and miR-142-5p have been previously reported to contribute to the pathogenesis of these diseases, and here they were identified as key regulators of the shared PPI network, suggesting a potential epigenetic link between MS and COPD. In conclusion, the results highlighted the potential role of peripheral blood leucocytes as a bridge between MS and COPD. These findings broaden our understanding of pathogenic contributors linking MS and COPD. While this transcriptomics study identified multiple key players, such as TP53, miR-218-5p, and miR-142-5p, the assessment of their therapeutic efficacy demands further experimental studies.

01 Apr 2025·Current Organic Synthesis

Changes in Germination Parameters, Growth and Development of Three Cultivars of Corn Seedlings under Various Aqueous Extracts of Mallow

Author: Sun, Wenli ; Shahrajabian, Mohamad Hesam ; Khoshkharam, Mehdi

Introduction::Allelopathy related to a positive or negative impacts on one type of plant, by a chemical produced by another type of plant such as weeds, and different kinds of chemicals are hydroxamic acids, phenolics, and short-chain fatty acids. The potential allelopathic impacts of weeds is directly associated to the plan species used, as well as to the concentration of the aqueous extract available in the environment.Methods::The present research manuscript attempts to find and identify the allelopathic interaction of aquatic extracts from dry shoots and seeds of mallow (Malva sylvestris L.) on germination, seed-ling growth and development of three cultivars of maize. Maize seeds (Zea mays L.) were obtained as seed material: three maize seed cultivars were KSC 704 (Cultivar 1), KSC 500 (Cultivar 2), and KSC 302 (Cultivar 3). The aqueous extracts of mallow shoots and seed, in concentration of 1, 3, 5%, were made from the dried and crumbled above-ground plant parts. The influence of plant dosage was significant on seedling vigour index (SVI), coefficient of the rate of germination (CRG), total germi-nation (T50), germination energy (GE), mean germination time (MGT), germination index (GI), in-hibition percentage (IP), fresh mass, dry mass, relative water content (RWC), and total water content (TWC). Different plant parts had meaningful influence on SVI, GI, MGT, CRG, GE, and IP. The impacts of cultivar on T50, IP, RWC, fresh mass, dry mass and TWC were significant. Along with the increase in the concentration of allelopathic components, a decrease in the germination activity of all tested maize cultivars was observed.Results::The highest SVI was related to control treatment followed by one and three percentage of plant dosages. KSC 704 obtained the maximum CRG and GE, and the minimum one was related to KSC 500. Three percentage of plant dosage has obtained the highest value of CRG and GE. The maximum and the minimum T50 was related to KSC 302 and KSC 704, respectively. The lowest values of GI and MGT was related to KSC 500, and the maximum values are related to KSC 704. While the maximum IP, RWC, fresh mass, dry mass and TWC was related to KSC 704, the lowest values were achieved in utilization of KSC 500. The RWC was the highest for seedlings grown on the 5% extract.Conclusion::The information of this article can be useful in the conditions of the threat of maize seedlings wit the mass appearance of mallow.

01 Apr 2025·Optics & Laser Technology

Tailoring performance through loss engineering in ring-waveguide lasers for enhanced Single-Mode lasing

Author: Yaghoobi, Mobin ; Parsanasab, Gholam-Mohammad ; Moradiani, Fatemeh ; Arvanagh, Pegah Eivazy ; Nematimansur, Nima

Loss engineering is a valuable approach for controlling the properties of ring-waveguide lasers.By carefully adjusting the waveguide′s loss parameters, it is possible to create customized lasers with improved performance for specific applications.In this study, we present the fabrication, characterization, and simulation of a ring-waveguide laser with loss-engineering capabilities.Initially, we optimized the waveguide′s cross-section to reduce scattering loss caused by side-wall roughness, achieving a low loss of 0.03 dB/cm.Next, we investigated the effect of the coupling coefficient on the lasing properties of the device by varying the gap between the waveguide and the resonator.Our exptl. results demonstrate that by fine-tuning the coupling coefficient, we can achieve single-mode lasing with an impressive side-mode suppression ratio (SMSR) of over 47 dB at a wavelength of 598 nm.These findings offer valuable insights into loss-engineering techniques for ring-waveguide lasers and showcase the potential for single-mode emission lasers with high stability, which can be applied in various fields.

100 Deals associated with Shahid Beheshti University

100 Translational Medicine associated with Shahid Beheshti University

Corporation Tree

Boost your research with our corporation tree data.

view full example data

Pipeline

Pipeline Snapshot as of 30 Jan 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Other

Current Projects

Drug(Targets)	Indications	Global Highest Phase

KBF-611 ( Mycolic acid synthase )	Tuberculosis More	Pending

Deal

Boost your decision using our deal data.

view full example data

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Profit

Explore the financial positions of over 360K organizations with Synapse.

view full example data

Grant & Funding(NIH)

Access more than 2 million grant and funding information to elevate your research journey.

view full example data

Investment

Gain insights on the latest company investments from start-ups to established corporations.

view full example data

Financing

Unearth financing trends to validate and advance investment opportunities.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

Shahid Beheshti University

Overview

Related

Corporation Tree

Pipeline

Pipeline Snapshot as of 30 Jan 2025

Current Projects

Deal

Translational Medicine

Profit

Grant & Funding(NIH)

Investment

Financing