Catalent Japan KK

To investigate the efficacy and safety of icosapentaenoic acid ethyl in Chinese patients with severe hypertriglyceridemia. (1) Efficacy: Change in serum TG level after 12 weeks of treatment compared with before treatment. (2) Safety: Adverse events during treatment

To evaluate the pharmacokinetics and safety of icosapentaenoic acid ethyl when administered orally as a single dose of 900 mg, 1800 mg, or 2700 mg, or as multiple doses of 1800 mg or 3600 mg daily in 2 divided doses for 8 days in healthy Chinese male adults.