Last update 07 Nov 2025
Apie Therapeutics, Inc.

Apie Therapeutics, Inc.

Startups
| Private Company|2020|North Carolina, United States|
10-50
|

Overview

Basic Info

Introduction
Apie Therapeutics is a private American company headquartered in Durham, North Carolina, that specializes in providing healthcare services. The company is founded by Esther M. Alegria. Apie Therapeutics is a preclinical regenerative medicines company that focuses on developing small-molecule drugs to stimulate the repair and regeneration of damaged vascular endothelium by utilizing resident stem cells. The company's initial focus is on rare diseases such as systemic sclerosis-interstitial lung disease (SSc-ILD), as well as nephropathies and metabolic syndrome, which are driven by chronic inflammation and fibrosis. Apie Therapeutics' pipeline candidates are orally active molecules designed to promote microvascular repair and restore tissue homeostasis in various acute and chronic disorders. The company's lead clinical candidate, APT101, is an optimized compound from a large and well-characterized chemical library licensed from RTI International, a nonprofit research institute.

Tags

Skin and Musculoskeletal Diseases
Other Diseases
Immune System Diseases
Small molecule drug

Disease domain score
A glimpse into the focused therapeutic areas
Technology Platform
Most used technologies in drug development
Targets
Most frequently developed targets
Disease DomainCount
Endocrinology and Metabolic Disease1
Top 5 Drug TypeCount
Small molecule drug2

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Pipeline

Pipeline Snapshot as of 13 Sep 2026

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3
Preclinical
1
1
IND Application
Other
3
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Current Projects

Drug(Targets)IndicationsGlobal Highest Phase
APT-101
( APLNR )
Scleroderma, Systemic
More
IND Application
APT-102 (Apie Therapeutics)
( CD39 )
Nephrotic Syndrome
More
Preclinical
APT-C (APIE Therapeutics)
COVID-19
More
Discontinued
APT-103
( APLNR )
Metabolic Syndrome
More
Discontinued
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Deal

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Boost your decision using our deal data.

Translational Medicine

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Boost your research with our translational medicine data.

Profit

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Grant & Funding(NIH)

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Investment

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Financing

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