[Translation] A randomized, double-blind, placebo-controlled, single-dose and multiple-dose ascending phase I clinical trial to evaluate the safety, tolerability, pharmacokinetic characteristics and food effects of oral administration of WT-1108 tablets in healthy Chinese adult subjects
主要目的:评估WT-1108片在健康成年受试者中单次和多次给药的安全性和耐受性。次要目的:评估WT-1108片在健康成年受试者中单次和多次给药的药代动力学(PK)特征及食物对口服WT-1108片的PK影响。探索性目的:WT-1108在人体的相关代谢物鉴定及相对丰度。
[Translation] Primary objective: To evaluate the safety and tolerability of WT-1108 tablets after single and multiple administration in healthy adult subjects. Secondary objective: To evaluate the pharmacokinetic (PK) characteristics of WT-1108 tablets after single and multiple administration in healthy adult subjects and the effect of food on the PK of oral WT-1108 tablets. Exploratory objective: To identify and determine the relative abundance of related metabolites of WT-1108 in humans.