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Endocrinology and Metabolic Disease

Neoplasms

Gene therapy

Oncolytic virus

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Technology Platform

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Disease Domain	Count

Endocrinology and Metabolic Disease	2
Neoplasms	1

Top 5 Drug Type	Count

Gene therapy	2
Oncolytic virus	1

Top 5 Target	Count

survivin(Baculoviral IAP repeat-containing protein 5)	1
HGF(Hepatocyte growth factor)	1
EGF(Epidermal growth factor)	1

Relationship between oral hygiene management after meals and salivary secretions for patients undergoing nasogastric tube feeding oral hygiene management after meals and salivary secretions for patients undergoing nasogastric tube feeding: A quasi-experimental study - Relationship between oral hygiene management after meals and salivary secretions for patients undergoing nasogastric tube feeding oral hygiene management after meals and salivary secretions for patients undergoing nasogastric tube feeding: A quasi-experimental study

Start Date07 May 2024

Sponsor / Collaborator

Kagoshima University

JPRN-UMIN000052609 / SuspendedIIT

Investigation of the usefulness of the aldehyde breath test with respect to gastrointestinal diseases - Investigation of the usefulness of the aldehyde breath test with respect to gastrointestinal diseases

Start Date01 Nov 2023

Sponsor / Collaborator

Kagoshima University

100 Clinical Results associated with Kagoshima University

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0 Patents (Medical) associated with Kagoshima University

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35,276

Literatures (Medical) associated with Kagoshima University

01 Mar 2025·Journal of Electronic Packaging

Application of the Nonlinear Fracture Mechanics Parameter ΔT* to Wire-Liftoff Lifetime Estimation of Power Modules at Elevated Temperatures

Author: Shishido, Nobuyuki ; Miyazaki, Noriyuki ; Hagihara, Seiya ; Akinaga, Yuki ; Koganemaru, Masaaki ; Hayama, Yutaka ; Taketomi, Shinya

AbstractPower modules are utilized to control electric power and play a key role in the systems for energy conversion. One of the reliability problems in power modules is the wire-liftoff, in which an aluminum wire delaminates from a silicon chip. The wire-liftoff phenomenon is a thermal fatigue failure caused by repeated temperature cycles during the operation of power modules. According to an experimental study, the wire-liftoff lifetime decreases with increase in the maximum junction temperature of a temperature cycle, Tmax, then levels off above 200 °C of Tmax. Such a saturation phenomenon of the wire-liftoff lifetime is main concern of the present study. We select the nonlinear fracture mechanics parameter T*-integral range, as a physical quantity describing the wire-liftoff lifetime. The T*-integral range, ΔT*, is only one fracture mechanics parameter that can be applied to thermal fatigue under a cyclic thermo-elastic-plastic creep condition. We perform nonlinear finite element analyses of a power module to calculate the ΔT* based on the mathematical expression of ΔT* for various temperature cycles. As a result, the ΔT* obtained from the exact method based on the mathematical expression of ΔT* is expected to be utilized for quantitative estimation of wire-liftoff lifetime in a wide temperature range of low to high temperatures.

01 Jan 2025·Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology

Comparative biochemical characterization of pufferfish saxitoxin and tetrodotoxin-binding protein (PSTBP) homologs in the plasma from four Takifugu species: Conservation of heat-stable PSTBP orthologs having three and two tandemly repeated lipocalin domains in genus Takifugu

Article

Author: Arima, Kazunari ; Zhang, Yafei ; Oshima, Yuji ; Arakawa, Osamu ; Takatani, Tomohiro ; Ueno, Mikinori ; Yamaguchi, Kenichi ; Tatsuno, Ryohei ; Sedanza, Mary Grace ; Shimasaki, Yohei

To study the relationship between domain characteristics of pufferfish saxitoxin and tetrodotoxin binding protein (PSTBP) proteoforms and their thermal stability, a comparative biochemical characterization of PSTBPs from the plasma of four Takifugu species (T. flavipterus, T. pardalis, T. alboplumbeus and T. rubripes) was conducted by Western blot analysis. The heat-tolerance tetrodotoxin (TTX)-binding ability of PSTBP proteoforms in T. rubripes plasma was verified by ultrafiltration and liquid chromatography tandem mass spectrometry (LC-MS/MS). These results suggest that the heat-stable PSTBP proteoforms, composed of three and two tandemly repeated lipocalin domains, are genetically conserved and ubiquitous in the genus Takifugu. This study builds on our knowledge of the structural and functional properties of PSTBP proteoforms, which is vital for understanding how toxins are transmitted and accumulate in organisms and is essential for evaluating the potential risks of toxins in seafood.

31 Dec 2024·Journal of Chemical Engineering of Japan

Effect of Gas Volume Expansion on Bubble Behavior in Fluidized Catalyst Beds

Author: Kai, Takami ; Ogata, Hironori ; Miyata, Hidekazu ; Nii, Susumu

Many industrially useful reactions involve changes in the total number of moles, resulting in changes in gas volume and superficial gas velocity.These changes influence hydrodynamics of fluidized beds, particularly bubble size, a critical parameter in the design because it affects the mass transfer rates between the bubble and emulsion phases.However, the effects of gas volume changes on bubble size remain largely unexplored.In this study, the effects of increasing molar number were investigated by exptl. simulating gas volume expansion through liquid evaporation within porous particles.In a three-dimensional fluidized bed, water-impregnated particles were fluidized with air, and the resulting pressure fluctuations were analyzed.Addnl., a two-dimensional fluidized bed was used to observe bubble behavior via video recording while ethanol-impregnated particles were fluidized with air.In catalytic reactions, the gas composition in the emulsion phase differs from the feed gas.Similarly, in the liquid evaporation studied here, the gas in the emulsion phase contains water vapor or ethanol in addition to air, affecting the properties of the mixed gas and the voidage of the emulsion phase and, consequently, bubble behavior.This research investigates the impact of gas volume expansion on bubble behavior while considering these effects.

100 Deals associated with Kagoshima University

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100 Translational Medicine associated with Kagoshima University

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Pipeline

Pipeline Snapshot as of 22 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

2

1

Phase 1 Clinical

Other

2

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Surv.m-CRA-1 ( survivin )	Neoplasms More	Phase 1
CN117279670 ( EGF )	Nutritional and Metabolic Diseases More	Discovery
CN116685340 ( HGF )	Nutritional and Metabolic Diseases More	Discovery
OKU-40	HIV Infections More	Pending
OKU-41	HIV Infections More	Pending