Quark was established in 1994 with the aim of creating a groundbreaking technology platform called BiFAR, which is designed to identify novel functional target genes and proteins. This innovative approach involves high throughput gene inactivation combined with microarray detection of the functional genes responsible for the occurrence of phenotypes of interest. With the recent advancements in siRNA technology, Quark's method has become increasingly popular in the industry for functional studies. The company has applied its BiFAR platform in gene discovery programs for serious diseases with significant unmet medical needs, often working with large pharmaceutical partners.

Tags

Nervous System Diseases

Eye Diseases

Otorhinolaryngologic Diseases

siRNA

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Nervous System Diseases	4
Immune System Diseases	2
Neoplasms	1

Top 5 Drug Type	Count

siRNA	11

Top 5 Target	Count

caspase 2(Caspase-2)	1

Drugs associated with Quark Pharmaceuticals, Inc.

Cosdosiran

Target

caspase 2

Mechanism

caspase 2 inhibitors [+2]

Active Org.

Suzhou Ribo Life Science Co., Ltd. [+2]

Originator Org.

BioSpring

Active Indication

Optic Neuropathy, Ischemic [+3]

Inactive Indication

Acute angle-closure glaucoma [+1]

Drug Highest PhasePhase 3

First Approval Ctry. / Loc.-

First Approval Date-

PF-4523655

Target

Redd1

Mechanism

Redd1 inhibitors [+1]

Active Org.

Pfizer Inc. [+1]

Originator Org.

Silence Therapeutics Plc

Active Indication

Diabetic macular oedema [+1]

Inactive Indication

Age Related Macular Degeneration [+3]

Drug Highest PhasePhase 2

First Approval Ctry. / Loc.-

First Approval Date-

QPI-1020R

Target-

Mechanism

RNA interference

Active Org.

Quark Pharmaceuticals, Inc.

Originator Org.

Quark Pharmaceuticals, Inc.

Active Indication

Conjunctivitis, Allergic

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date-

Clinical Trials associated with Quark Pharmaceuticals, Inc.

NCT04654221 / TerminatedNot Applicable

Evaluation of eGFR, Determined by Cystatin C and Creatinine, and mGFR, Measured by Iohexol Clearance, in Subjects at High Risk for Acute Kidney Injury (AKI) Following Cardiac Surgery

To evaluate the differences between serum cystatin C based estimated glomerular filtration rate (eGFRcys), serum creatinine based eGFR (eGFRcreat) and measured glomerular filtration rate (mGFR) in subjects at high risk for acute kidney injury (AKI) approximately 90 days following cardiac surgery

Start Date21 Feb 2020

Sponsor / Collaborator

Quark Pharmaceuticals, Inc.

NCT03510897 / TerminatedPhase 3

A Randomized, Double-Blind, Placebo Controlled, Phase 3 Study to Evaluate the Efficacy and Safety of QPI-1002 for the Prevention of Major Adverse Kidney Events (MAKE) in Subjects at High Risk for Acute Kidney Injury (AKI) Following Cardiac Surgery

This trial is designed to evaluate QPI-1002 versus placebo for the prevention of Major Adverse Kidney Events (MAKE) in subjects at high risk for acute kidney injury following cardiac surgery. Half of the participants will receive QPI-1002 while the other half will receive placebo.

Start Date29 Jun 2018

Sponsor / Collaborator

Quark Pharmaceuticals, Inc.

CTR20170011 / SuspendedPhase 2/3

单剂或多剂玻璃体腔注射QPI-1007 治疗急性非动脉炎性前部缺血性视神经病变的随机、双盲、假注射对照的 II/III 期试验

[Translation] A randomized, double-blind, sham-controlled phase II/III trial of single or multiple intravitreal injections of QPI-1007 for the treatment of acute nonarteritic anterior ischemic optic neuropathy

主要目的： 1. 评定近期发作型 NAION 受试者中 QPI-1007 玻璃体内 (IVT) 注射的安全性和耐受性。 2. 确定近期发作型 NAION 受试者中 QPI-1007 玻璃体内 (IVT) 注射对视觉功能的影响。次要目的：评价近期发作型 NAION 受试者中施用 QPI-1007 后视乳头周围视网膜神经纤维层 (pRNFL) 和神经节细胞层的结构性变化。

[Translation]

Primary Objectives: 1. To assess the safety and tolerability of intravitreal (IVT) injections of QPI-1007 in subjects with recent-onset NAION. 2. To determine the effects of intravitreal (IVT) injections of QPI-1007 on visual function in subjects with recent-onset NAION. Secondary Objectives: To evaluate structural changes in the peripapillary retinal nerve fiber layer (pRNFL) and ganglion cell layer after administration of QPI-1007 in subjects with recent-onset NAION.

Start Date09 Nov 2017

Sponsor / Collaborator

Quark Pharmaceuticals, Inc.

[+2]

100 Clinical Results associated with Quark Pharmaceuticals, Inc.

0 Patents (Medical) associated with Quark Pharmaceuticals, Inc.

Literatures (Medical) associated with Quark Pharmaceuticals, Inc.

01 Aug 2021·Experimental NeurologyQ2 · MEDICINE

RTP801 regulates motor cortex synaptic transmission and learning

Q2 · MEDICINE

Article

Author: Solana-Balaguer, Júlia ; Masana, Mercè ; Gilbert, James P ; Malagelada, Cristina ; Llobet, Arnau ; Rodríguez, Manuel José ; Man, Heng-Ye ; Canal, Mercè ; Feinstein, Elena ; Pérez-Sisqués, Leticia ; Williamson, David L ; Martín-Flores, Núria ; Sánchez-Fernández, Núria ; Soto, David ; Gasull, Xavier ; Romaní-Aumedes, Joan ; Alberch, Jordi ; Campoy-Campos, Genís ; García-García, Esther ; Fernández-García, Sara

BACKGROUNDRTP801/REDD1 is a stress-regulated protein whose upregulation is necessary and sufficient to trigger neuronal death in in vitro and in vivo models of Parkinson's and Huntington's diseases and is up regulated in compromised neurons in human postmortem brains of both neurodegenerative disorders. Indeed, in both Parkinson's and Huntington's disease mouse models, RTP801 knockdown alleviates motor-learning deficits.RESULTSWe investigated the physiological role of RTP801 in neuronal plasticity and we found RTP801 in rat, mouse and human synapses. The absence of RTP801 enhanced excitatory synaptic transmission in both neuronal cultures and brain slices from RTP801 knock-out (KO) mice. Indeed, RTP801 KO mice showed improved motor learning, which correlated with lower spine density but increased basal filopodia and mushroom spines in the motor cortex layer V. This paralleled with higher levels of synaptosomal GluA1 and TrkB receptors in homogenates derived from KO mice motor cortex, proteins that are associated with synaptic strengthening.CONCLUSIONSAltogether, these results indicate that RTP801 has an important role modulating neuronal plasticity and motor learning. They will help to understand its role in neurodegenerative disorders where RTP801 levels are detrimentally upregulated.

01 Jan 2018·Molecular vision

TGF-β-induced IOP elevations are mediated by RhoA in the early but not the late fibrotic phase of open angle glaucoma.

Article

Author: Logan, Ann ; Hill, Lisa J ; Blanch, Richard J ; Berry, Martin ; Thomas, Chloe N ; Mead, Ben ; Feinstein, Elena ; Foale, Simon ; Ahmed, Zubair

PurposeElevations in intraocular pressure (IOP) are associated with the development of glaucoma and loss of sight. High transforming growth factor-β (TGF-β) 1 levels in the eye's anterior chamber can lead to dysfunctional contractions through RhoA signaling in trabecular meshwork (TM) cells and IOP spikes. Sustained high TGF-β levels leads to TM fibrosis and sustained increases in IOP. We investigated whether inhibiting RhoA, using a siRNA-mediated RhoA (siRhoA), controls IOP by altering TM expression of fibrosis and contractility-related proteins in a rodent model of glaucoma.MethodsTGF-β was injected intracamerally twice a week into adult Sprague Dawley rats, and IOP was recorded with tonometry. Animals were euthanized on day 7 and 35 with TM expression of fibrosis and contractility-related proteins, as well as survival of retinal ganglion cells (RGCs) assessed with immunohistochemistry. siRNA against RhoA or enhanced green fluorescent protein (EGFP) was also injected intracamerally into select animals. Successful RhoA knockdown was determined with quantitative reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemistry, and the effects of the knockdown on the parameters above analyzed.ResultsTGF-β caused increased TM contractile proteins and IOP spikes by day 7, sustained increases in IOP from day 15, and TM fibrosis at day 35. siRhoA abolished the transient 7 day IOP rise but not the later sustained IOP increase (due to fibrosis). At 35 days, TGF-β-related RGC loss was not prevented with siRhoA treatment.ConclusionsWe conclude that RhoA signaling mediates the early IOP rise induced by TM cellular changes associated with contractility but not the sustained IOP elevation caused by TM fibrosis. Thus, RhoA therapies offer a clinically relevant opportunity for IOP management, likely through the modulation of TM contractility, but appear to be ineffective in the amelioration of fibrosis.

01 Sep 2017·Kidney International ReportsQ3 · MEDICINE

Safety and Tolerability Study of an Intravenously Administered Small Interfering Ribonucleic Acid (siRNA) Post On-Pump Cardiothoracic Surgery in Patients at Risk of Acute Kidney Injury

Q3 · MEDICINE

ArticleOA

Author: Burnier, Michel ; Squiers, Elizabeth ; Chawla, Lakhmir S ; Silberman, Shuli ; Shernan, Stanton Keith ; Khan, Samina ; Demirjian, Segav ; Erlich, Shai ; Polinsky, Martin ; Ailawadi, Gorav ; Hamilton, Marta ; Rothenstein, Daniel ; Bitran, Dani

INTRODUCTIONPatients undergoing on-pump cardiac surgery are at an increased risk of acute kidney injury. QPI-1002, a small interfering ribonucleic acid, is under clinical development for the prevention of acute kidney injury. The safety, tolerability, and pharmacokinetics of QPI-1002 was evaluated in this first-in-man, Phase 1 study of a small, interfering ribonucleic acid in patients at risk of acute kidney injury after on-pump cardiac surgery.METHODSIn this phase 1 randomized, placebo-controlled dose-escalation study, a single i.v. dose of QPI-1002 was administered in subjects undergoing on-pump cardiac surgery. Subjects received placebo (n = 4), or QPI-1002 in increasing doses of 0.5 mg/kg (n = 3), 1.5 mg/kg (n = 3), 5 mg/kg (n = 3), and 10 mg/kg (n = 3).RESULTSA total of 16 subjects were enrolled in the study. The average maximum concentration and area under the curve from the time of dosing to the last measurable concentration of QPI-1002 were generally dose proportional, indicating that exposure increased with increasing dose. The average mean residence time (mean residence time to the last measurable concentration) was 10 to 13 minutes in all 4 drug-dosing cohorts. Adverse events occurred at a similar rate in all study groups. Of the total 109 reported adverse events, the events were distributed as 26 in the placebo group and 21, 19, 24, and 19 in the QPI-1002 0.5, 1.5, 5.0, and 10.0 mg/kg groups, respectively. Eight of the 16 subjects experienced at least 1 serious adverse event: 4 (100%) in the placebo group and 4 (33.3%) in the combined QPI-1002 cohorts.DISCUSSIONQPI-1002 was rapidly eliminated from plasma. QPI-1002 was safe and well tolerated across all dose groups. Overall, no dose-limiting toxicities or safety signals were observed in the study. Further development of QPI-1002 for prophylaxis of acute kidney injury is warranted.

News (Medical) associated with Quark Pharmaceuticals, Inc.

23 Jan 2024

·www.biospace.com

Alkeus Pharmaceuticals Appoints Seemi Khan, M.D., Chief Medical Officer

CAMBRIDGE, Mass., Jan. 23, 2024 (GLOBE NEWSWIRE) -- Alkeus Pharmaceuticals, Inc. today announced that Seemi Khan, M.D., M.P.H., M.B.A., has joined the Company as Chief Medical Officer. “We are thrilled to welcome Dr. Khan to the Alkeus executive team as we pursue our mission to innovate transformative therapies for degenerative eye diseases,” said Leonide Saad, Ph.D., President and CEO at Alkeus. “An accomplished executive, Dr. Khan has a track record in bringing rare disease treatments to patients in need across multiple therapeutic areas.” Prior to joining Alkeus, Dr. Khan served as Chief Medical Officer at Reata Pharmaceuticals through its acquisition by Biogen, where she oversaw all clinical programs from early stage to commercialization. Dr. Khan was instrumental in the approval and launch of the first treatment for Friedreich’s ataxia. Dr. Khan’s experience also includes senior leadership roles at Mitsubishi Tanabe Pharma America, Quark Pharmaceuticals, Abbott and AbbVie. An internist and nephrologist with expertise in rare disease, immunology and rheumatology, she has served as an Assistant Professor of Medicine at Tufts University School of Medicine. She further has received an M.P.H. from Harvard T.H. Chan School of Public Health and an M.B.A. from Brandeis University. "I am excited to join Alkeus, particularly at a time when gildeuretinol has shown promising advancement toward the treatment of Stargardt disease,” Dr. Khan said. “I’m eager to continue building the team to bring significant impact on the lives of individuals confronted with progressive vision loss. My commitment to medical innovation and patient care aligns seamlessly with Alkeus' mission, and I look forward to driving forward this life-changing treatment." About Alkeus Pharmaceuticals Alkeus Pharmaceuticals is a biopharmaceutical company with headquarters in Cambridge, Mass. Co-founded by Leonide Saad, Ph.D. and Ilyas Washington, Ph.D., Alkeus is focused on developing therapies for serious diseases of the eye with high unmet need. Alkeus’ lead candidate, gildeuretinol (ALK-001), is currently being evaluated in clinical trials for the treatment of Stargardt disease and for geographic atrophy (GA) secondary to age-related macular degeneration (AMD). About Gildeuretinol (ALK-001) Gildeuretinol acetate (ALK-001) is a novel molecule created as a specialized form of deuterated vitamin A designed to reduce the dimerization of vitamin A without disrupting vision. In preclinical studies, gildeuretinol decreased vitamin A dimerization to the normal rate seen in unaffected individuals and prevented retinal degeneration and blindness in animals with Stargardt disease. In addition to the TEASE trials, a Phase 3 study of gildeuretinol in 200 patients with geographic atrophy (GA) secondary to age-related macular degeneration (AMD) has recently been completed and is expected to read out topline data in 2024. Gildeuretinol has received breakthrough therapy designation and orphan drug designation by the U.S. Food and Drug Administration. For further information, please contact: David Setboun, Chief Operating Officer Email: media01@alkeuspharma.com Website:

Phase 3Executive ChangeBreakthrough TherapyOrphan DrugClinical Result

28 Nov 2023

·www.biospace.com

CellChorus Appoints Andrew Last, PhD, to Board of Directors

Dr. Last brings more than three decades worth of experience leading a variety of life sciences organizations HOUSTON, Texas — November 28, 2023 — CellChorus Inc., the leader in applying artificial intelligence to visually evaluate how cells perform and interact over time, announced the appointment of Andrew Last, PhD, to its board of directors. Dr. Last brings more than three decades of experience leading global life sciences businesses to advise the CellChorus team as it grows the TIMING™ franchise. He currently serves as Executive Vice President and Chief Operating Officer of Bio-Rad Laboratories (NYSE: BIO and BIOb), a global leader of life science research and clinical diagnostic products with nearly $3 billion in revenue. Dr. Last previously served as Chief Commercial Officer at Berkeley Lights. Prior to that he was Chief Operating Officer at both Intrexon Corporation and Affymetrix. Dr. Last has also held senior positions with Becton, Dickinson and Company; Applied Biosystems; Incyte Genomics; and Monsanto Company. He holds a PhD with Agrochemical Specialization and an MS in Bio-Aeronautics from Cranfield University, UK, as well as a BS from the University of Leicester, UK. “Andy has had a front seat at some of the most exciting scientific and commercial advances in life sciences over the past several decades,” said Daniel Meyer, CEO of CellChorus. “We are thrilled to have his guidance as CellChorus advances the next frontier of single-cell analysis to provide scientists with a comprehensive understanding of how their cells interact and perform.” About CellChorus CellChorus® is the leader in applying artificial intelligence (AI) to visually evaluate how thousands of individual immune cells, such as T cells and NK cells, perform over time. The company applies Time lapse Imaging Microscopy in Nanowell Grids (TIMING™) with neural network-based AI to identify cells and evaluate their activity, including how they move, activate, kill and survive. The patent-protected CellChorus platform can link TIMING data and insights with information from other analysis modalities such as single-cell RNA sequencing and flow cytometry to provide a comprehensive understanding of cellular function, state and phenotype for the life sciences industry. Please visit cellchorus.com for more information. Company Contact: Daniel Meyer Chief Executive Officer CellChorus Inc. TIMING@cellchorus.com

Executive Change

07 Mar 2023

·www.prnewswire.com

$2.14 Billion Worldwide Antisense & RNAi Therapeutics Industry to 2032: Rising Prevalence of Coronary Artery Diseases, Neurodegenerative Disorders and Infectious Diseases Drives Growth

DUBLIN, March 7, 2023 /PRNewswire/ -- The "Antisense & RNAi Therapeutics Global Market Report 2023" report has been added to ResearchAndMarkets.com's offering. This report provides strategists, marketers and senior management with the critical information they need to assess the market. The global antisense & RNAI therapeutics market is expected to grow from $1.32 billion in 2021 to $1.42 billion in 2022 at a compound annual growth rate (CAGR) of 8%. The antisense & RNAi therapeutics market is expected to reach $2.14 billion in 2026 at a CAGR of 10.8%. Reasons to Purchase Gain a truly global perspective with the most comprehensive report available on this market covering 50+ geographies. Understand how the market has been affected by the coronavirus and how it is responding as the impact of the virus abates. Assess the Russia - Ukraine war's impact on agriculture, energy and mineral commodity supply and its direct and indirect impact on the market. Measure the impact of high global inflation on market growth. Create regional and country strategies on the basis of local data and analysis. Identify growth segments for investment. Outperform competitors using forecast data and the drivers and trends shaping the market. Understand customers based on the latest market shares. Benchmark performance against key competitors. Suitable for supporting your internal and external presentations with reliable high quality data and analysis Major players in the antisense & RNAi therapeutics market are Alnylam Pharmaceuticals, Benitec Biopharma Ltd., Gene Signal, GlaxoSmithKline Plc, Ionis Pharmaceuticals, Marina Biosciences, Quark Pharmaceuticals, Sanofi S.A, Acuitas Therapeutics and Antisense Therapeutics Ltd. The antisense and RNAi therapeutics market includes revenues earned by entities by regulating gene expression at multiple levels, such as at replication, transcription, and translation. The market value includes the value of related goods sold by the service provider or included within the service offering. Only goods and services traded between entities or sold to end consumers are included. Antisense therapy refers to the selective, sequence-specific suppression of gene expression by single-stranded DNA oligonucleotides. Contrarily, RNA interference (RNAi) is activated by double-stranded RNA (dsRNA) and results in the sequence-specific mRNA degradation of single-stranded target RNAs. The main technologies of antisense & RNAi therapeutics are RNA interference and antisense RNA. RNA interference is a conserved biological response to double-stranded RNA that mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids and regulates protein-coding gene expression. The various route of administration includes pulmonary delivery, intravenous injections, intra-dermal injections, intraperitoneal injections, topical delivery, and other delivery methods that are used for the indication of oncology, cardiovascular diseases (CVDs), respiratory disorders, neurological disorders, infectious diseases, other. The rising prevalence of coronary artery diseases, neurodegenerative disorders, and infectious diseases is projected to contribute to the demand for the antisense & RNAi therapeutics market. Gene suppression approaches including RNA interference and antisense oligonucleotides are used for the treatment of various neurodegenerative conditions by repairing mutant genes. According to the National Institute of Environmental Health Sciences, Alzheimer's disease and Parkinson's disease are the most common neurodegenerative diseases affecting millions of people globally. In the USA, around 930,000 people had Parkinson's disease by the end of 2020. Furthermore, according to the World Health Organization (WHO), infectious diseases are a major concern and dominated the WHO's list of health threats ranging from various climate change issues to inadequate healthcare facilities. Hence, the growing prevalence of several neurodegenerative diseases and infectious diseases is expected to drive the growth of the antisense & RNAi therapeutics market. The high cost of RNA interference-based drugs is expected to act as a major restraint on the growth of the antisense & RNAi therapeutics market in the future. For instance, according to Future Medicine, the price of Onpattro is approximately $450,000 per year. Onpattro (patisaran) is the RNA interference-based drug used for the treatment of polyneuropathy of hereditary transthyretin-mediated (hATTR) amyloidosis in adults. Stringent regulations, a long product approval process, high development cost, and a comparably small number of patients are a few factors leading to the high cost of RNA interference drugs, which is expected to hinder the antisense & RNAi therapeutics market growth in upcoming years. Major companies operating in the antisense & RNAi therapeutics market are undertaking strategic initiatives such as collaborations and partnerships for product innovation to sustain in the increasingly competitive market, companies are developing innovative products as well as sharing skills and expertise with other companies. While companies have long collaborated as well as with academic and research institutions in this market by way of partnerships, and in or out-licensing deals. This trend has been increasing over recent years. The regions covered in the antisense & RNAi therapeutics market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa. The countries covered in the antisense & RNAi therapeutics market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK and USA. Key Topics Covered: 1. Executive Summary 2. Antisense & RNAi Therapeutics Market Characteristics 3. Antisense & RNAi Therapeutics Market Trends And Strategies 4. Antisense & RNAi Therapeutics Market - Macro Economic Scenario 4.1 COVID-19 Impact On Antisense & RNAi Therapeutics Market 4.2 Ukraine-Russia War Impact On Antisense & RNAi Therapeutics Market 4.3 Impact Of High Inflation On Antisense & RNAi Therapeutics Market 5. Antisense & RNAi Therapeutics Market Size And Growth 5.1. Global Antisense & RNAi Therapeutics Historic Market, 2017-2022, $ Billion 5.1.1. Drivers Of The Market 5.1.2. Restraints On The Market 5.2. Global Antisense & RNAi Therapeutics Forecast Market, 2022-2027F, 2032F, $ Billion 5.2.1. Drivers Of The Market 5.2.2. Restraints On the Market 6. Antisense & RNAi Therapeutics Market Segmentation 6.1. Global Antisense & RNAi Therapeutics Market, Segmentation By Technology, Historic and Forecast, 2017-2022, 2022-2027F, 2032F, $ Billion RNA Interference Antisense RNA 6.2. Global Antisense & RNAi Therapeutics Market, Segmentation By Route of Administration, Historic and Forecast, 2017-2022, 2022-2027F, 2032F, $ Billion Pulmonary Delivery Intravenous Injections Intra-dermal Injections Intraperitoneal Injections Topical Delivery Other Delivery Methods 6.3. Global Antisense & RNAi Therapeutics Market, Segmentation By Indication, Historic and Forecast, 2017-2022, 2022-2027F, 2032F, $ Billion Oncology Cardiovascular Diseases (CVDs) Respiratory Disorders Neurological Disorders Infectious Diseases Other Indications 7. Antisense & RNAi Therapeutics Market Regional And Country Analysis 7.1. Global Antisense & RNAi Therapeutics Market, Split By Region, Historic and Forecast, 2017-2022, 2022-2027F, 2032F, $ Billion 7.2. Global Antisense & RNAi Therapeutics Market, Split By Country, Historic and Forecast, 2017-2022, 2022-2027F, 2032F, $ Billion For more information about this report visit About ResearchAndMarkets.com ResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends. Media Contact: Research and Markets Laura Wood, Senior Manager [email protected] For E.S.T Office Hours Call +1-917-300-0470 For U.S./CAN Toll Free Call +1-800-526-8630 For GMT Office Hours Call +353-1-416-8900 U.S. Fax: 646-607-1907 Fax (outside U.S.): +353-1-481-1716 Logo: SOURCE Research and Markets

OligonucleotidesiRNA

100 Deals associated with Quark Pharmaceuticals, Inc.

100 Translational Medicine associated with Quark Pharmaceuticals, Inc.

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Pipeline Snapshot as of 22 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

Phase 3 Clinical

Other

Current Projects

Drug(Targets)	Indications	Global Highest Phase

Cosdosiran ( caspase 2 )	Optic Nerve Injuries More	Phase 3
QPI-1010	Acne Vulgaris More	Preclinical
AHLi-11	Hearing Disorders More	Preclinical
QP-AL1	Alopecia More	Preclinical
QPI-3000R	Hearing Loss More	Preclinical

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