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Digestive System Disorders

Neoplasms

Respiratory Diseases

Oncolytic virus

Small molecule drug

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Disease Domain	Count

Neoplasms	3
Infectious Diseases	1

Top 5 Drug Type	Count

Oncolytic virus	3
Small molecule drug	1

Top 5 Target	Count

HCCS1(suppressor of tumorigenicity 20)	1
LeuRS(Leucyl-tRNA synthetase)	1
SMAC(diablo IAP-binding mitochondrial protein)	1
TRAIL receptor	1

The genetic relationship among Chaetoceros curvisetus, Ch. debilis and Ch. gracilis is studied using mol. biol. methods.The nuclear-encoded rDNA gene and ITS sequences (about 2800 bp corresponding to 3'-end of SSU rDNA gene and the 5'-end of LSU rDNA gene) were amplified, cloned and sequenced.The sequences homol. anal., phylogenetic tree construction, and AP-PCR fingerprint comparison were conducted.Results show that sequence homologies between each part of rDNA gene are 97%-100%, and ITS sequences have more than 99% homologies.The evolutionary distances among them are very close, but AP-PCR fingerprint patterns of the 3 Chaetoceros are different.The close genetic relationship of the 3 Chaetoceros is concluded, and that 3 Chaetoceros belong to one family is suggested.

Gaojishu Tongxun

Development of competitive enzyme linked immunosorbent assays and their application for quantification of Chaetoceros curvisetus and Chaetoceros debilis

Author: Gou, Wanli ; Sun, Jun ; Wang, Tanchun ; Li, Rongxiu ; Qi, Haigang ; Yu, Zhigang ; Xin, Zeyu ; Mi, Tiezhu

Polyclonal antibodies (PAbs) against Chaetoceros curvisetus and Chaetoceros debilis were preparedBoth PAbs were specifically reactive with 3 Chaetoceros, but not with other genera of algae by dot immunoassay and competitive enzyme-Linked immunosorbent assay (ELISA).Competitive ELISAs were developed for the detection of C. curvisetus and C. debilis resp.The measure ranges are 146-350000 cells and 521-1250000 cells, and the detection limits are 146 cells and 521 cells, resp.Quantifications of C. curvisetus and C. debilis were performed by using the cELISAs, and the results are consistent with those obtained by manual counts under optical microscope.

Xiandai Mianyixue

Research progress of NLRP3 inflammasome

Author: Mao, Kai-rui ; Sun, Bing

A review.NLRP3 inflammasome plays important roles in immune reaction and disease of organisms.NLRP3 inflammasome can be activated by various pathogens and risk signals.NLRP3 inflammasome might be a new target for treating inflammatory diseases.

100 Deals associated with Shanghai Institutes for Biological Sciences CAS

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100 Translational Medicine associated with Shanghai Institutes for Biological Sciences CAS

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Pipeline

Pipeline Snapshot as of 05 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

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9

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

ZCL-039 ( LeuRS )	Pneumonia, Bacterial More	Preclinical
Ad.SPDD-HCCS1 ( HCCS1 )	Hepatocellular Carcinoma More	Preclinical
ZD55-TRAIL ( TRAIL receptor )	Hepatocellular Carcinoma More	Preclinical
ZD55-Smac ( SMAC )	Hepatocellular Carcinoma More	Preclinical
Nifeviroc ( CCR5 )	HIV Infections More	Discontinued