Last update 01 Nov 2024

HCCS1

Last update 01 Nov 2024

Basic Info

Synonyms

HCCS-1, HCCS1, Human cervical cancer suppressor gene 1 protein

+ [3]

Introduction

May act as a tumor suppressor. Promotes apoptosis of cancer cells.

Drugs associated with HCCS1

Ad.SPDD-HCCS1

Target

HCCS1

Mechanism

HCCS1 modulators

Active Org.

Shanghai Institutes for Biological Sciences CAS

Originator Org.

Shanghai Institutes for Biological Sciences CAS

Active Indication

Hepatocellular Carcinoma

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with HCCS1

100 Translational Medicine associated with HCCS1

0 Patents (Medical) associated with HCCS1

Literatures (Medical) associated with HCCS1

01 Mar 2024·Hypertension

Genome-Wide Interaction Analysis With DASH Diet Score Identified Novel Loci for Systolic Blood Pressure

Article

Author: Liu, Ching-Ti ; Bentley, Amy R. ; Beilin, Lawrence J. ; de Mutsert, Renée ; Munroe, Patricia B. ; Guo, Xiuqing ; Fretts, Amanda M. ; Warren, Helen R. ; Heerkens, Luc ; Lemaitre, Rozenn N. ; Rosendaal, Frits R. ; van Dam, Rob M. ; Mori, Trevor A. ; Rao, D.C. ; Rebholz, Casey M. ; Franceschini, Nora ; Gauderman, W. James ; de Vries, Paul S. ; Huan, TianXiao ; McKeown, Nicola M. ; Wang, Carol A. ; Voortman, Trudy ; Tinker, Lesley F. ; Bartz, Traci M. ; Chen, Han ; Tai, E. Shyong ; Ma, Jiantao ; Winkler, Thomas W. ; Guirette, Mélanie ; Chen, Honglei ; Morrison, Alanna C. ; Lan, Jessie ; Noordam, Raymond ; Levy, Daniel ; Oddy, Wendy H. ; Tanaka, Toshiko ; Liu, Jianjun ; Kooperberg, Charles ; van Rooij, Jeroen ; Neuhouser, Marian L. ; Pennell, Craig E. ; Sim, Xueling ; Kim, Hyunju ; Brown, Michael R. ; Whitton, Clare ; Chai, Jin Fang

BACKGROUND:The Dietary Approaches to Stop Hypertension (DASH) diet score lowers blood pressure (BP). We examined interactions between genotype and the DASH diet score in relation to systolic BP.METHODS:We analyzed up to 9 420 585 single nucleotide polymorphisms in up to 127 282 individuals of 6 population groups (91% of European population) from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (n=35 660) and UK Biobank (n=91 622) and performed European population-specific and cross-population meta-analyses.RESULTS: We identified 3 loci in European-specific analyses and an additional 4 loci in cross-population analyses at Pinteraction <5e−8. We observed a consistent interaction between rs117878928 at 15q25.1 (minor allele frequency, 0.03) and the DASH diet score ( Pinteraction =4e−8; P for heterogeneity, 0.35) in European population, where the interaction effect size was 0.42±0.09 mm Hg ( Pinteraction =9.4e−7) and 0.20±0.06 mm Hg ( Pinteraction =0.001) in Cohorts for Heart and Aging Research in Genomic Epidemiology and the UK Biobank, respectively. The 1 Mb region surrounding rs117878928 was enriched with cis-expression quantitative trait loci (eQTL) variants ( P =4e−273) and cis-DNA methylation quantitative trait loci variants ( P =1e−300). Although the closest gene for rs117878928 is MTHFS , the highest narrow sense heritability accounted by single nucleotide polymorphisms potentially interacting with the DASH diet score in this locus was for gene ST20 at 15q25.1. CONCLUSIONS:We demonstrated gene-DASH diet score interaction effects on systolic BP in several loci. Studies with larger diverse populations are needed to validate our findings.

01 Feb 2024·PNAS Nexus

Decoding the genetic symphony: Profiling protein-coding and long noncoding RNA expression in T-acute lymphoblastic leukemia for clinical insights

Article

Author: Verma, Deepak ; Pramanik, Raja ; Sharma, Atul ; Arora, Mohit ; Bakhshi, Sameer ; Kapoor, Shruti ; Benjamin, Mercilena ; Nayak, Baibaswata ; Scaria, Vinod ; Kumar, Rajive ; Singh, Jay ; Chopra, Anita ; Sharma, Disha ; Seth, Rachna ; Kumari, Sarita ; Palanichamy, Jayanth Kumar ; Sivasubbu, Sridhar

AbstractT-acute lymphoblastic leukemia (T-ALL) is a heterogeneous malignancy characterized by the abnormal proliferation of immature T-cell precursors. Despite advances in immunophenotypic classification, understanding the molecular landscape and its impact on patient prognosis remains challenging. In this study, we conducted comprehensive RNA sequencing in a cohort of 35 patients with T-ALL to unravel the intricate transcriptomic profile. Subsequently, we validated the prognostic relevance of 23 targets, encompassing (i) protein-coding genes—BAALC, HHEX, MEF2C, FAT1, LYL1, LMO2, LYN, and TAL1; (ii) epigenetic modifiers—DOT1L, EP300, EML4, RAG1, EZH2, and KDM6A; and (iii) long noncoding RNAs (lncRNAs)—XIST, PCAT18, PCAT14, LINC00202, LINC00461, LINC00648, ST20, MEF2C-AS1, and MALAT1 in an independent cohort of 99 patients with T-ALL. Principal component analysis revealed distinct clusters aligning with immunophenotypic subtypes, providing insights into the molecular heterogeneity of T-ALL. The identified signature genes exhibited associations with clinicopathologic features. Survival analysis uncovered several independent predictors of patient outcomes. Higher expression of MEF2C, BAALC, HHEX, and LYL1 genes emerged as robust indicators of poor overall survival (OS), event-free survival (EFS), and relapse-free survival (RFS). Higher LMO2 expression was correlated with adverse EFS and RFS outcomes. Intriguingly, increased expression of lncRNA ST20 coupled with RAG1 demonstrated a favorable prognostic impact on OS, EFS, and RFS. Conclusively, several hitherto unreported associations of gene expression patterns with clinicopathologic features and prognosis were identified, which may help understand T-ALL's molecular pathogenesis and provide prognostic markers.

17 Aug 2023·Microbiology spectrum

Comprehensive Genomic Characterization of Staphylococcus aureus Isolated from Atopic Dermatitis Patients in Japan: Correlations with Disease Severity, Eruption Type, and Anatomical Site.

Article

Author: Kutsuno, Shoko ; Obata, Shoko ; Amagai, Masayuki ; Iwao, Yasuhisa ; Arai, Chika ; Masuda, Kanako ; Ebihara, Tamotsu ; Fukushima-Nomura, Ayano ; Kawasaki, Hiroshi ; Hisatsune, Junzo ; Tanese, Keiji ; Sugai, Motoyuki

Atopic dermatitis (AD) shows frequent recurrence. Staphylococcus aureus is the primary microbial component in AD and is associated with disease activity. However, traditional typing methods have failed to characterize virulent AD isolates at the clone level. We conducted a comprehensive genomic characterization of S. aureus strains isolated from the skin of AD patients and healthy donors, comparing the whole-genome sequences of the 261 isolates with anatomical and lesional (AD-A)/nonlesional (AD-NL)/healthy sites, eruption types, clinical scores, virulence, and antimicrobial resistance gene repertoires in Japan. Sequence type (ST) diversity was lost with worsening disease activity; ST188 was the most frequently detected ST in AD-A and had the strongest correlation with AD according to the culture rate and proportion with worsening disease activity. ST188 and ST20 isolates inhabited all skin conditions, with significantly higher proportions in AD skin than in healthy skin. ST8, ST15, and ST5 proportions were equivalent for all skin conditions; ST30 was detected only in healthy skin; and ST12 was detected only in AD skin. ST97 detected in AD-A and healthy skin was clearly branched into two subclades, designated ST97_A and ST97_H. A comparison of two genomes led to the discovery that only ST97_A possessed the complete trp operon, enabling bacterial survival without exogenous tryptophan (Trp) on AD skin, where the Trp level was significantly reduced. Primary STs showing an AD skin inhabitation trend (ST188, ST97_A, ST20, and ST12) were all trp operon positive. The predominant clones (ST188 and ST97) possessed almost no enterotoxin genes, no mecA gene, and few other antimicrobial resistance genes, different from the trend observed in Europe/North America. IMPORTANCE While Staphylococcus aureus is a member of the normal human skin flora, its strong association with the onset of atopic dermatitis (AD) has been suggested. However, previous studies failed to assign specific clones relevant to disease activities. Enterotoxins produced by S. aureus have been suggested to aggravate and exacerbate the inflammation of AD skin, but their role remains ambiguous. We conducted a nuanced comprehensive characterization of isolates from AD patients and healthy donors, comparing the whole-genome sequences of the isolates with anatomical and lesional/nonlesional/healthy sites, eruption types, clinical scores, virulence, and antimicrobial resistance gene repertoires in Japan. We demonstrate that specific clones are associated with disease severity and clinical manifestations, and the dominant clones are devoid of enterotoxin genes and antimicrobial resistance genes. These findings undermine the established notion of the pathophysiological function of S. aureus associated with AD and introduce a new concept of S. aureus colonization in AD.

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HCCS1

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