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Last update 23 Jan 2025

HCCS1

Last update 23 Jan 2025

Basic Info

Synonyms

HCCS-1, HCCS1, Human cervical cancer suppressor gene 1 protein

+ [3]

Introduction

May act as a tumor suppressor. Promotes apoptosis of cancer cells.

Drugs associated with HCCS1

Ad.SPDD-HCCS1

Target

HCCS1

Mechanism

HCCS1 modulators

Active Org.

Shanghai Institutes for Biological Sciences CAS

Originator Org.

Shanghai Institutes for Biological Sciences CAS

Active Indication

Hepatocellular Carcinoma

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with HCCS1

100 Translational Medicine associated with HCCS1

0 Patents (Medical) associated with HCCS1

Literatures (Medical) associated with HCCS1

01 Mar 2025·Journal of Global Antimicrobial Resistance

Molecular characterization of methicillin-susceptible/resistant Staphylococcus aureus from bloodstream infections in northern Japan: The dominance of CC1-MRSA-IV, the emergence of human-associated ST398 and livestock-associated CC20 and CC97 MSSA

Article

Author: Ohashi, Nobuhide ; Osada, Masako ; Urushibara, Noriko ; Ito, Masahiko ; Tada, Kousuke ; Hirose, Mina ; Aung, Meiji Soe ; Kobayashi, Nobumichi ; Yamada, Kazuki ; Kawaguchiya, Mitsuyo

OBJECTIVESStaphylococcus aureus (S. aureus) is a major cause of bloodstream infections. The recent epidemiological features and antimicrobial resistance trend were analysed for methicillin-resistant and susceptible S. aureus (MRSA/MSSA) isolates from blood samples in people from northern Japan.METHODSThe S. aureus isolates from blood culture were screened by matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) and genotyped by the schemes of multilocus sequence typing (MLST), coa, agr, spa, and SCCmec types. Antimicrobial resistance genes and virulence factors were detected by multiplex/uniplex polymerase chain reaction (PCR). Antimicrobial susceptibility was examined using a broth microdilution test.RESULTSA total of 301 isolates (163 MRSA and 138 MSSA) were isolated from bloodstream infections in 2023 (from April to December). The MRSA isolates were classified into three groups, that is, clonal complexes (CC)1-SCCmec-IV (CC1-IV) (52%), CC5-II (36%), and CC8-IV (12%). The prevalence of CC1 was significantly higher than those in our previous studies (2017-2021). Four CC8-IVa isolates with PVL genes on ΦSa2usa were considered to be the USA300 clone (sequence type [ST]8/spa-t008/coa IIIa/agr I) or its variants that were genotyped as those closely related to ST8/t008 or lacking arginine catabolic mobile element (ACME). In contrast, MSSA was genetically highly divergent and classified into 22 STs, with CC1 (ST1 and ST188) being the most common (25%). It was notable that 29 MSSA isolates (21%) were classified into livestock-associated (LA) genotypes, ST20, ST97, and CC398 (ST398 and ST291). Genetic characterization of the CC398 isolates suggested that these belong to human-adapted MSSA clones.CONCLUSIONSThe present study revealed the increasing trend of CC1 MRSA surpassing CC5, and the emergence of MSSA representing human-adapted CC398, and LA types ST97 and ST20 from bloodstream infections in people in Japan. © 2024 The Author(s). Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy.

01 Mar 2024·Hypertension

Genome-Wide Interaction Analysis With DASH Diet Score Identified Novel Loci for Systolic Blood Pressure

Article

Author: de Mutsert, Renée ; Liu, Ching-Ti ; Beilin, Lawrence J. ; Bentley, Amy R. ; Munroe, Patricia B. ; Guo, Xiuqing ; Fretts, Amanda M. ; Warren, Helen R. ; Heerkens, Luc ; Lemaitre, Rozenn N. ; Rosendaal, Frits R. ; Rebholz, Casey M. ; Mori, Trevor A. ; Rao, D.C. ; van Dam, Rob M. ; Franceschini, Nora ; Huan, TianXiao ; de Vries, Paul S. ; Gauderman, W. James ; Voortman, Trudy ; McKeown, Nicola M. ; Tinker, Lesley F. ; Wang, Carol A. ; Bartz, Traci M. ; Tai, E. Shyong ; Chen, Han ; Ma, Jiantao ; Winkler, Thomas W. ; Guirette, Mélanie ; Chen, Honglei ; Morrison, Alanna C. ; Noordam, Raymond ; Levy, Daniel ; Lan, Jessie ; Oddy, Wendy H. ; Tanaka, Toshiko ; Liu, Jianjun ; Kooperberg, Charles ; van Rooij, Jeroen ; Neuhouser, Marian L. ; Pennell, Craig E. ; Sim, Xueling ; Kim, Hyunju ; Brown, Michael R. ; Whitton, Clare ; Chai, Jin Fang

BACKGROUND:The Dietary Approaches to Stop Hypertension (DASH) diet score lowers blood pressure (BP). We examined interactions between genotype and the DASH diet score in relation to systolic BP.METHODS:We analyzed up to 9 420 585 single nucleotide polymorphisms in up to 127 282 individuals of 6 population groups (91% of European population) from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (n=35 660) and UK Biobank (n=91 622) and performed European population-specific and cross-population meta-analyses.RESULTS: We identified 3 loci in European-specific analyses and an additional 4 loci in cross-population analyses at Pinteraction <5e−8. We observed a consistent interaction between rs117878928 at 15q25.1 (minor allele frequency, 0.03) and the DASH diet score ( Pinteraction =4e−8; P for heterogeneity, 0.35) in European population, where the interaction effect size was 0.42±0.09 mm Hg ( Pinteraction =9.4e−7) and 0.20±0.06 mm Hg ( Pinteraction =0.001) in Cohorts for Heart and Aging Research in Genomic Epidemiology and the UK Biobank, respectively. The 1 Mb region surrounding rs117878928 was enriched with cis-expression quantitative trait loci (eQTL) variants ( P =4e−273) and cis-DNA methylation quantitative trait loci variants ( P =1e−300). Although the closest gene for rs117878928 is MTHFS , the highest narrow sense heritability accounted by single nucleotide polymorphisms potentially interacting with the DASH diet score in this locus was for gene ST20 at 15q25.1. CONCLUSIONS:We demonstrated gene-DASH diet score interaction effects on systolic BP in several loci. Studies with larger diverse populations are needed to validate our findings.

01 Mar 2024·Veterinary microbiology

Pasteurella multocida ST20 is widespread in Australian poultry farms and may infect wild waterbirds.

Article

Author: Noormohammadi, Amir H ; Stent, Andrew W ; Browning, Glenn F ; Bushell, Rhys N ; Whiteley, Pam ; Allen, Joanne L ; Marenda, Marc S

The bacterial agent that causes fowl cholera, Pasteurella multocida, was isolated from two deceased wild waterbirds in Victoria, Australia, in 2013. Whole genome sequence analysis placed the isolates into ST20, a subtype described in farmed chickens from Queensland, Australia and more recently in feedlot cattle and in pigs across a broader area of the continent. This study also found ST20 between 2009 and 2022 on three chicken farms and two turkey farms located in four Australian states. The sequences of 25 of these ST20 isolates were compared to 280 P. multocida genomes from 23 countries and to 94 ST20 Illumina datasets from Queensland that have been deposited in public databases. The ST20 isolates formed a single phylogenetic clade and were clustered into four sub-groups with highly similar genomes, possessing either LPS type 1 or type 3 loci. Various repertoires of mobile genetic elements were present in isolates from farmed, but not wild birds, suggesting complex histories of spill-over between avian populations and gene acquisition within farm environments. No major antimicrobial resistance was predicted in any of the ST20 isolates by the genomic analysis. The closest relative of these isolates was a ST394 bovine respiratory tract isolate from Queensland, which differed from ST20 by only one allele and carried beta-lactam and tetracycline resistance genes. These findings underline the importance of understanding the role of wild and commercial birds in the maintenance of fowl cholera, and of implementing regular epidemiological surveillance and biosecurity management programmes in wildlife, as well as free-range poultry farms.

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HCCS1

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