Delving into the Latest Updates on Hainan Pharmaceutical Factory Co. Ltd. with Synapse

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Eye Diseases

Skin and Musculoskeletal Diseases

Infectious Diseases

Small molecule drug

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Disease Domain	Count

Infectious Diseases	1

Top 5 Drug Type	Count

Small molecule drug	1

Top 5 Target	Count

DHPS(Dihydropteroate synthase)	1

An ultra performance liquid chromatography coupled with photodiode array detector and time-of-flight tandem mass spectrometry (UPLC-PDA-TOF-MS) method was developed for the quality assessment of Danmu preparations, a commonly used traditional Chinese medicine. Thirty-three compounds from Danmu preparations were simultaneously detected; among them, 14 compounds were unequivocally identified based on their retention behaviors, UV spectrum, MS and MS(n) data by comparing with reference substances, and the others were tentatively characterized by literatures. Twelve of 33 compounds were simultaneously determined by UPLC-PDA, and the validation of the quantitative method, including recoveries, linearity, sensitivity, precision and repeatability was carried out and the results demonstrated to be satisfied the requirements of quantitative analysis. The results suggested that the established method would be a powerful and reliable analytical tool for quality control of Danmu preparations and the characterization of multi-constituent in complex chemical system.

01 Nov 2013·China Journal of Chinese Materia Medica

Multi-dimensional structure quality control technology system of Danmu injection based on component structural theory

Author: Xiao-Bin Jia ; Fen-Xia Zhu ; Rong Yin ; Xiu-Feng Li

Danmu is one of common medicines in folks of Li nationality, with such effects in clearing heat and removing toxicity, antisepsis and anti-inflammation. Danmu injection, which is developed with Danmu herbs, has been clinically applied for years and showed curative efficacy. Currently, though many studies have been conducted to analyze chemical constituents in Danmu in details, its pharmacodynamic material basis related to disease prevention and treatment has not been defined. Furthermore, as the quality control methods for Danmu and its preparations remain restricted to single index component and irrational to some extent, it fails to ensure their inherent quality. On the basis of the summary of previous study results, as well as the "component structural theory" of the material basis, we established a "multi-dimensional structure quality control technology system" that is capable of reflecting the integrity of effects of Danmu injection and component structure hierarchy, and performed a dynamic monitoring over the whole process from medicinal materials and preparation products, so as to ensure the inherent quality of Danmu injection.

01 Nov 2013·Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Multi-dimensional structure quality control technology system of Danmu injection based on component structural theory].

Article

Author: Yin, Rong ; Zhu, Fen-Xia ; Li, Xiu-Feng ; Jia, Xiao-Bin

Danmu is one of common medicines in folks of Li nationality, with such effects in clearing heat and removing toxicity, antisepsis and anti-inflammation. Danmu injection, which is developed with Danmu herbs, has been clinically applied for years and showed curative efficacy. Currently, though many studies have been conducted to analyze chemical constituents in Danmu in details, its pharmacodynamic material basis related to disease prevention and treatment has not been defined. Furthermore, as the quality control methods for Danmu and its preparations remain restricted to single index component and irrational to some extent, it fails to ensure their inherent quality. On the basis of the summary of previous study results, as well as the "component structural theory" of the material basis, we established a "multi-dimensional structure quality control technology system" that is capable of reflecting the integrity of effects of Danmu injection and component structure hierarchy, and performed a dynamic monitoring over the whole process from medicinal materials and preparation products, so as to ensure the inherent quality of Danmu injection.

100 Deals associated with Hainan Pharmaceutical Factory Co. Ltd.

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100 Translational Medicine associated with Hainan Pharmaceutical Factory Co. Ltd.

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Pipeline

Pipeline Snapshot as of 19 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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