Delving into the Latest Updates on Nbios, Inc. with Synapse

Overview

Tags

Neoplasms

Nervous System Diseases

Digestive System Disorders

Monoclonal antibody

Herbal medicine

Chemical drugs

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Neoplasms	6
Nervous System Diseases	2
Endocrinology and Metabolic Disease	1
Immune System Diseases	1

Top 5 Drug Type	Count

Monoclonal antibody	4
Herbal medicine	3
Chemical drugs	2

Top 5 Target	Count

CTSZ(cathepsin Z)	1
LPAR2(lysophosphatidic acid receptor 2)	1

Codium fragile has been traditionally used in oriental medicine to treat enterobiasis, dropsy, and dysuria, and it has been shown to possess many biological properties. Atopic dermatitis (AD) is one of the types of skin inflammation and barrier disruption, which leads to chronic inflammatory skin diseases. In the current investigation, the protective effects of C. fragile extract (CFE) on anti-inflammation and skin barrier improvement were investigated. In LPS-stimulated RAW 264.7 cells, nitric oxide generation and the expression levels of interleukin (IL)-1β, IL-4, IL-6, iNOS, COX-2, and tumor necrosis factor-alpha (TNF)-α were reduced by CFE. CFE also inhibited the phosphorylation of NF-κB-p65, ERK, p-38, and JNK. Additionally, CFE showed inhibitory activity on TSLP and IL-4 expression in HaCaT cells stimulated with TNF-α/interferon-gamma (IFN-γ). Enhanced expression of factors related to skin barrier function, FLG, IVL, and LOR, was confirmed. These findings implied that CFE may be used as a therapeutic agent against AD due to its skin barrier-strengthening and anti-inflammatory activities, which are derived from natural marine products.

100 Deals associated with Nbios, Inc.

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100 Translational Medicine associated with Nbios, Inc.

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Corporation Tree

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Pipeline

Pipeline Snapshot as of 23 Dec 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

2

7

Preclinical

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

NB_Ab_002	Neoplasms More	Preclinical
NB_C_002	Brain Cancer More	Preclinical
NB_C_001	Colorectal Cancer More	Preclinical
NB_NC_003	Hangover from alcohol More	Preclinical
NB_NC_001	Nonalcoholic fatty liver More	Preclinical