Delving into the Latest Updates on Al-Azhar University with Synapse

Overview

Tags

Neoplasms

Skin and Musculoskeletal Diseases

Other Diseases

Small molecule drug

Biological products

Herbal medicine

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Neoplasms	8
Infectious Diseases	2
Endocrinology and Metabolic Disease	1
Hemic and Lymphatic Diseases	1
Immune System Diseases	1

Top 5 Drug Type	Count

Small molecule drug	8
Herbal medicine	1
Biological products	1

Top 5 Target	Count

JNK2(c-Jun N-terminal kinase 2)	2
CLPP(caseinolytic mitochondrial matrix peptidase proteolytic subunit)	1
EGFR(Epidermal growth factor receptor erbB1)	1
E2F1 x MUC4 x PTEN	1
Top II(Topoisomerase II)	1

• All periodontitis patients with infra bony pockets to be included in this study will diagnosed as having stage III periodontitis with probing pocket depth (PPD) ≥ 6 mm, and clinical attachment loss (CAL) ≥ 5mm will be treated by minimally invasive non-surgical therapy or by injectable bone putty

Start Date04 Nov 2024

Sponsor / Collaborator

Al-Azhar University

100 Clinical Results associated with Al-Azhar University

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0 Patents (Medical) associated with Al-Azhar University

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28,871

Literatures (Medical) associated with Al-Azhar University

01 Dec 2025·Nano-Micro Letters

Advanced Functional Electromagnetic Shielding Materials: A Review Based on Micro-Nano Structure Interface Control of Biomass Cell Walls

Review

Author: Huang, Runzhou ; Luo, Jing ; Hou, Hua ; Shi, Yang ; Guo, Zhanhu ; Li, Jianzhang ; Jiang, Jinxuan ; Xu, Kaimeng ; Wu, Mingjun ; Jia, Chong ; El-Bahy, Zeinhom M ; Asiri, Yazeed M ; Ge, Shengbo ; Amin, Mohammed A ; Chen, Xiangmeng ; Qiu, Hua ; Alshammari, Anoud Saud

AbstractResearch efforts on electromagnetic interference (EMI) shielding materials have begun to converge on green and sustainable biomass materials. These materials offer numerous advantages such as being lightweight, porous, and hierarchical. Due to their porous nature, interfacial compatibility, and electrical conductivity, biomass materials hold significant potential as EMI shielding materials. Despite concerted efforts on the EMI shielding of biomass materials have been reported, this research area is still relatively new compared to traditional EMI shielding materials. In particular, a more comprehensive study and summary of the factors influencing biomass EMI shielding materials including the pore structure adjustment, preparation process, and micro-control would be valuable. The preparation methods and characteristics of wood, bamboo, cellulose and lignin in EMI shielding field are critically discussed in this paper, and similar biomass EMI materials are summarized and analyzed. The composite methods and fillers of various biomass materials were reviewed. this paper also highlights the mechanism of EMI shielding as well as existing prospects and challenges for development trends in this field.

01 Feb 2025·Journal of Molecular Structure

New heterocycles from dehydroacetic acid (DHA). Synthesis, antimicrobial activity, DNA gyrase inhibition, antioxidant activity, and molecular docking study

Author: El-Sawy, Eslam R. ; Abdel-Aziz, Mohamed S. ; Abdel-Aziem, Anhar ; Kirsch, Gilbert ; Abdelmegeed, Heba

Dehydroacetic acid (DHA) is a significant heterocyclic mol. whose derivatives are highly prevalent.Thus, a new series of heterocyclic derivatives starting from dehydroacetic acid were synthesized and investigated for their antimicrobial and antioxidant activities.The antimicrobial activity of the twenty-one new compounds was determined against S. aureus ATCC 6538-P, E. coli ATCC 25922, C. albicans ATCC 10231, and A. niger NRRL A-326.Out of twenty one compounds, 7a, 8a, 9, 10d and 14 showed promising in vitro antimicrobial activity.Compounds 7a, 8a, and 10d were equipotent to ciprofloxacin reference drug against S. aureus, while compounds 9 and 14 were 4-fold and 2-fold higher than ciprofloxacin, resp.For E. coli, compounds 9 and 10d were equipotent to ciprofloxacin whereas compounds 7a, 8a, and 14 were 4-fold, 8-fold, and 2-fold higher than ciprofloxacin, resp.Regarding C. albicans,7a showed moderate activity with 2-fold lower than nystatin (reference drug).To further analyze the antimicrobial potential of the compounds (7a, 8a, 9, 10d, and 14), their in vitro inhibitory activity against E. coli DNA gyrase was evaluated.The results revealed that compound 8a showed the lowest IC₅₀ required for DNA gyrase inhibition almost similar IC₅₀ to ciprofloxacin.A mol. docking study was established to assess the binding mode of 8a, the most active derivative, with the crystal structure of DNA gyrase B (PDB: 5MMN). 8a demonstrated a good binding mode inside the active pocket of the DNA gyrase B with good binding energy value.Addnl., 8a displayed the highest antioxidant activity compared with ascorbic acid.Collectively, the compound 8a is a highly promising antimicrobial candidate for further studies.

01 Feb 2025·Parasitology International

Chemical composition and bio-efficacy of agro-waste plant extracts and their potential as bioinsecticides against Culex pipiens mosquitoes

Article

Author: Alkhaibari, Abeer Mousa ; Alasmari, Saeed M ; Alasmari, Saeed M. ; Selim, Abdelfattah ; Baz, Mohamed M. ; Abdelkhalk, Heba F. ; Gattan, Hattan S ; Abdelkhalek, Heba F ; El-Tabakh, Mohamed A M ; Baz, Mohamed M ; Alruhaili, Mohammed H. ; El-Tabakh, Mohamed A.M. ; Gattan, Hattan S. ; Alruhaili, Mohammed H

Mosquitoes are considered one of the most lethal creatures on the planet and are responsible for millions of fatalities annually through the transmission of several diseases to humans. Green trash is commonly employed in agricultural fertilizer manufacturing and microbial bioprocesses for energy production. However, there is limited information available on the conversion of green waste into biocides. This study investigates the viability of utilizing green waste as a new biopesticide against Culex pipiens mosquito larvae. The current study found that plant extracts from Punica granatum (98.4 % mortality), Citrus sinensis (92 % mortality), Brassica oleracea (88 % mortality), Oryza sativa (81.6 % mortality), and Colocasia esculenta (53.6 % mortality) were very good at killing Cx. pipiens larvae 24 h post-treatment. The LC₅₀ values were 314.43, 370.72, 465.59, 666.67, and 1798.03 ppm for P. granatum, C. sinensis, B. oleracea, O. sativa, and C. esculenta, respectively. All plant extracts, particularly P. granatum extract (14.93 and 41.87 U/g), showed a significant reduction in acid and alkaline phosphate activity. Additionally, pomegranate extract showed a significant decrease (90 %) in field larval density, with a stability of up to five days post-treatment. GC-MS results showed more chemical classes, such as terpenes, esters, fatty acids, alkanes, and phenolic compounds. HPLC analysis revealed that the analyzed extracts had a high concentration of phenolic and flavonoid components. Moreover, there are many variations among these plants in the amount of each compound. The docking interaction showed a simulation of the atomic-level interaction between a protein and a small molecule through the binding site of target proteins, explaining the most critical elements influencing the enzyme's activity or inhibitions. The study's findings showed that the various phytochemicals found in agro-waste plants had high larvicidal activity and provide a safe and efficient substitute to conventional pesticides for pest management, as well as a potential future in biotechnology.

100 Deals associated with Al-Azhar University

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100 Translational Medicine associated with Al-Azhar University

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Pipeline

Pipeline Snapshot as of 22 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

1

8

Preclinical

Other

2

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Autologous fat(Al-Azhar University)	Scleroderma, Localized More	Clinical
1,5-Diarylpyrazole derivatives-6h ( EGFR )	Neoplasms More	Preclinical
ZG180 ( CLPP )	Inflammation More	Preclinical
Derivative XIII( Al-Azhar University) ( CDK9 )	Liver Cancer More	Preclinical
Thymoquinone ( E2F1 x MUC4 x PTEN )	Breast Cancer More	Preclinical