Delving into the Latest Updates on Al-Azhar University with Synapse

Overview

Tags

Neoplasms

Skin and Musculoskeletal Diseases

Digestive System Disorders

Small molecule drug

Biological products

Herbal medicine

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Neoplasms	11
Endocrinology and Metabolic Disease	1
Hemic and Lymphatic Diseases	1
Infectious Diseases	1
Immune System Diseases	1

Top 5 Drug Type	Count

Small molecule drug	11
Herbal medicine	1
Chemical drugs	1
Biological products	1

Top 5 Target	Count

CDK9(Cyclin-dependent kinase 9)	4
JNK2(c-Jun N-terminal kinase 2)	2
CLPP(caseinolytic mitochondrial matrix peptidase proteolytic subunit)	1
EGFR(Epidermal growth factor receptor erbB1)	1
E2F1 x MUC4 x PTEN	1

PURPOSEPseudoachondroplasia is a rare skeletal dysplasia caused by a mutation in the COMP gene. Infants with pseudoachondroplasia present with rhizomelic dwarfism. Pseudoachondroplasia can resemble achondroplasia, which also presents with a phenotype of rhizomelic dwarfism. The differentiation between these two conditions is important because while both can present with cervicomedullary compromise, the underlying pathophysiology and its management is entirely different.RESULTSWe present a case of a 13-year-old female patient with pseudoachondroplasia who presented with cervical myelopathy and imaging evidence of atlantoaxial instability with an os odontoideum and a retro-odontoid cystic soft tissue mass, causing C1-2 canal stenosis and cervical cord compression. She underwent C1 decompression and C1-2 posterior cervical fixation. Post-operative imaging demonstrated improved alignment of the os odontoideum, and complete resolution of the retro-odontoid soft tissue mass. We contend that retro-odontoid masses are a marker of local C1-2 joint instability and restoration of atlanto-axial alignment with posterior fixation and fusion alone is likely to be sufficient for regression of the mass and associated compression.CONCLUSIONPseudoachondroplasia can present with atlantoaxial instability and cervicomedullary compromise and with retro-odontoid masses. The differentiation from achondroplasia is crucially important for surgical decision-making and management should include surgical decompression and fixation.

100 Deals associated with Al-Azhar University

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100 Translational Medicine associated with Al-Azhar University

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Pipeline

Pipeline Snapshot as of 23 Jan 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

1

12

Preclinical

Other

2

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Autologous fat(Al-Azhar University)	Scleroderma, Localized More	Clinical
1,5-Diarylpyrazole derivatives-5d ( JNK2 )	Neoplasms More	Preclinical
1,5-Diarylpyrazole derivatives-6h ( EGFR )	Neoplasms More	Preclinical
ZG180 ( CLPP )	Inflammation More	Preclinical
Derivatives VII (Al-Azhar University) ( CDK9 )	Colorectal Cancer More	Preclinical