Delving into the Latest Updates on Avicena Group, Inc. with Synapse

Overview

The neuroprotective effects of dietary creatine or cyclocreatine supplementation were studied in mouse model of familial amyotrophic lateral sclerosis, in rats given malonate or 3-nitropropionate neurotoxins (model of Huntington disease), and in mice given 1,2,3,6-tetrahydro-1-methyl-4-phenylpyridine (MPTP) (model of Parkinson disease).Behavioral and brain histol. and biochem. evaluations were performed.Brain levels of creatine, phosphocreatine, lactate, IMP, AMP, ADP, ATP, salicylate, 2,3-DHBA, 2,5-DHBA, tyrosine, and 3-nitrotyrosine were measured in the 3-nitropropionate study.Brain levels of dopamine, 3,4-dihydroxyphenylacetic acid, and homovanillic acid were determined in the MPTP study.The creatine supplementation had neuroprotective effects in all 3 models of neurodegenerative diseases.

100 Deals associated with Avicena Group, Inc.

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100 Translational Medicine associated with Avicena Group, Inc.

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Pipeline

Pipeline Snapshot as of 23 Dec 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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