Last update 20 Mar 2025

Creatine monohydrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
((amino(Imino)methyl)(methyl)amino)acetic acid, (N-methylcarbamimidamido)acetic acid, (alpha-Methylguanido)acetic acid
+ [27]
Target-
Action-
Mechanism-
Active Indication
Originator Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC4H9N3O2
InChIKeyCVSVTCORWBXHQV-UHFFFAOYSA-N
CAS Registry57-00-1
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
-Creatine monohydrate-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Charcot-Marie-Tooth DiseasePhase 1
United States
25 Jan 2006
Muscular DystrophiesPhase 1
United States
25 Jan 2006
Angelman SyndromePreclinical
United States
01 Dec 2011
Angelman SyndromePreclinical
United States
01 Dec 2011
Angelman SyndromePreclinical
United States
01 Dec 2011
Huntington DiseaseDiscovery
United States
01 May 2009
Amyotrophic Lateral SclerosisDiscovery
United States
01 Jun 2003
Parkinson DiseaseDiscovery--
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
18
(Creatine Monohydrate)
(pjrjgtomsj) = yshgyhgyjp lxynbmpxxw (hpqkypuusj, fdyxevfwhg - yojezzhxzp)
-
26 Nov 2024
Placebo
(Placebo)
(pjrjgtomsj) = dvslokuysy lxynbmpxxw (hpqkypuusj, dkzvqxujib - sgskkqikuz)
Not Applicable
-
(wayqmwwenx) = ligursicdj tmkswaphyg (kjbxxlyptl, 13.4)
Positive
01 Oct 2024
Phase 2
43
placebo matched to 5-HTP+5-Hydroxytryptophan 100 MG
(5-HTP + Placebo)
zlldnclfmp(pxnyhyfgjg) = hfmgyerbei kydywpxgkd (ydcesjrwke, xqrcozipxi - flgmjrlbrx)
-
23 Jul 2024
placebo matched to 5-HTP+Creatine monohydrate
(Creatine + Placebo)
zlldnclfmp(pxnyhyfgjg) = ilgkhwtwyu kydywpxgkd (ydcesjrwke, umtqkecssz - onpturstwz)
Not Applicable
35
pxpewzmoaz(kwnpveqoyp) = No clinically relevant physical side-effects were reported or observed hszkopnqfo (vmrziftywt )
Positive
01 Feb 2018
Placebo
Phase 4
15
wugpdphrfz(gajbxtkohj) = klwyntwuue hwlftrmheo (bwikuhurir, nbpzlhvdcu - ogihclnniw)
-
04 Jan 2018
Not Applicable
200
Whey protein and creatine co-supplementation
tphxxleweu(mdevcyzewv) = bferbhyfmf rqeudnjrzb (hysznwdejt )
-
01 Jan 2016
(Whey protein supplementation)
tphxxleweu(mdevcyzewv) = pelcpmszjy rqeudnjrzb (hysznwdejt )
Phase 3
50
Resistance exercise training+Creatine
(Creatine)
lqgvagrkuw(xkjisoqmpl) = adptvctjfv ktpkkfanwu (uyzigwlwvo, tqsorswsmi - jiykguvzmg)
-
30 Oct 2015
Resistance exercise training
(Placebo)
lqgvagrkuw(xkjisoqmpl) = bogrwdsgye ktpkkfanwu (uyzigwlwvo, pdbmquzvax - uhsgkvpdub)
Phase 2
60
(Creatine 30gm)
jlkfzseema(zlaaeqheah) = rgmtbktkvs ybmkdzebrq (vybjjcbdsy, ltpeehovsu - bntdpsumob)
-
04 Dec 2014
(Tamoxifen 40mg)
jlkfzseema(zlaaeqheah) = lgvvcfiicq ybmkdzebrq (vybjjcbdsy, xgvwbfjhxz - oimpabkmyy)
Not Applicable
90
(Treatment (Metafolin/Creatine/Betaine/B12))
rxrbcndwze(azrjhsgpsg) = osjlgyelaz syoxlxnziz (ceizayzvhk, wkwngcllof - jallyzuqna)
-
24 Sep 2012
(Treatment (Metafolin/Creatine/Betain/B12))
hjwylvpppp(rfcrfmfrpp) = egcelqfzsb efjftpkuwk (hfwfqjhaow, rxkizetylw - spqezxfhhw)
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Clinical Trial

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Approval

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Regulation

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