Sarcopenia, generally characterized by the age-related reduction in muscle strength, lean/muscle mass and functional ability, is also associated with reduced bone mass and strength and impaired brain health and function. One potential intervention which has received much 'hype' over the past few decades to countermeasure these negative consequences of biological aging is creatine monohydrate supplementation.

RECENT FINDINGS:

From a skeletal muscle perspective, the combination of creatine monohydrate supplementation and resistance training provides 'hope' for older adults as it improves measures of lean mass, regional (limb) muscle thickness, upper- and lower-body muscle strength and functional ability. Further, there is some evidence that creatine (supplementation or habitual diet) provides a ray of 'hope' for improving some aspects of cognitive function. The majority of research suggests that creatine is more 'hype' than 'hope' for improving measures of bone mass in older adults. Creatine monohydrate supplementation provides some anti-sarcopenic benefits for older adults.

01 Feb 2025·FISH PHYSIOLOGY AND BIOCHEMISTRY

Multi-omics analysis and longitudinal study of reprogramming by dietary creatine to endogenous metabolism in largemouth bass (Micropterus salmoides)

Article

Author: Yu, Haodong ; Ran, Xinping ; Li, Shaoyun ; Nie, Yukang ; Rong, Keming ; Zhang, Xuezhen

Creatine is a feed additive with physiological pleiotropic properties and also an energy homeostasis protector in vertebrates and is successfully used in terrestrial livestock and aquaculture. Here, two feeding trials were performed to investigate dietary creatine on endogenous creatine metabolism and physiological reprogramming in largemouth bass. The results showed that the endogenous creatine metabolism genes AGAT, GAMT, and SLC6A8 of largemouth bass are highly conserved with the amino acid sequences of other teleosts and are clustered separately from mammals. Among the 16 major tissues in largemouth bass, both creatine synthesis genes (agat, gamt) and transporter gene slc6a8 are most highly expressed in muscle. Muscle has a high threshold but sensitive creatine negative feedback to regulate endogenous creatine metabolism. Dietary creatine intake significantly inhibits endogenous creatine synthesis and transport in muscle in a dose-dependent manner, and this inhibitory effect recovers with a decrease in dietary creatine content. In addition, physiological creatine saturation required prolonged exogenous creatine intake, and it would be shortened by high doses of creatine, which provides guidance for maximizing economic benefits in aquaculture. Metabolome and transcriptome showed that dietary creatine significantly affected the metabolism of the creatine precursor substance-arginine. Exogenous creatine intake spared arginine that would otherwise be used for creatine synthesis, increased arginine levels, and caused reprogramming of arginine metabolism. Overall, these results demonstrate that the addition of creatine to largemouth bass diets is safe and recoverable, and the benefits of creatine intake in largemouth bass are not limited to enhancing the function of creatine itself but also include a reduction in the metabolic burden of essential amino acids to better growth performance.

01 Jan 2025·EUROPEAN NEUROPSYCHOPHARMACOLOGY

Efficacy and safety profile of oral creatine monohydrate in add-on to cognitive-behavioural therapy in depression: An 8-week pilot, double-blind, randomised, placebo-controlled feasibility and exploratory trial in an under-resourced area

Article

Author: Dorjee, Sangila ; De Giorgi, Riccardo ; Sherpa, Nima Norbu ; Dolma, Tenzin ; Choudhury, Amrita ; Ostinelli, Edoardo Giuseppe

Pre-clinical and clinical evidence proposes that creatine monohydrate, an affordable nutraceutical, could be a useful adjunct to conventional antidepressant treatments. In this pilot feasibility and exploratory study, we investigate the 8-week effects of creatine in addition to cognitive-behavioural therapy (CBT) versus placebo plus CBT in depression. For the primary efficacy outcome of change in Patient Health Questionnaire-9 depression score at study endpoint, we used mixed-model repeated measures analysis of covariance. Logistic regressions were employed to assess acceptability (any-cause dropouts), tolerability (dropouts for adverse events), and safety (patients experiencing one or more adverse events). We calculated effect sizes adjusted for age, sex, and baseline depression score. One-hundred participants (50 females, mean age= 30.4 ± 7.4 years) with depression (mean PHQ-9 = 17.6 ± 6.3) were randomised to either creatine+CBT (N = 50) or placebo+CBT (N = 50). At 8 weeks, PHQ-9 scores were lower in both study arms, but significantly more so in participants taking creatine (mean difference= -5.12). Treatment discontinuations due to any cause and to adverse events, and proportion of participants with at least one adverse event were comparable between study arms. This hypothesis-generating trial suggests that creatine could be a useful and safe supplement to CBT for depression. Longer and larger clinical trials are warranted.

News (Medical) associated with Creatine monohydrate

12 Dec 2023

·www.businesswire.com

WHOOP Announces Its “Year In Review” Celebrating That 2023 Was the Year Human Performance Became a Lifestyle

BOSTON--( BUSINESS WIRE )-- WHOOP , the human performance company, today released its annual Year in Review , highlighting the ways members unlocked their healthy obsessions in 2023, and identifies health and wellness patterns for 2024. The WHOOP community increased its commitment to their overall health and fitness and gained invaluable insights across Sleep, Strain, Recovery, and Stress, as WHOOP turns a dynamic understanding of the body into a healthy obsession, made possible by its latest innovations including Stress Monitor , Strength Trainer , and WHOOP Coach . The past year revealed that the biggest trends in health and wellbeing were centered on lifestyle shifts aiming to optimize performance. From changes in alcohol consumption, to the rise of new recovery behaviors like ice baths and red light therapy, 2023 saw an influx of circadian, nutritional, longevity, and health promoting habits. WHOOP data shows that even the smallest behavioral changes can have a big impact on the body and mind. “‘Year in Review’ is one of our favorite features to launch each year,” said Will Ahmed, Founder and CEO of WHOOP. “It's an important way to celebrate our members’ accomplishments and reflect on changing trends around the world.” Recovery - The best new buzz comes from ice baths, not booze. Alcohol consumption is down. WHOOP members consumed alcohol less frequently in 2023, but when they did, they consumed more, with an average of three drinks per sitting. Ice baths for recovery have shown a strong increase in popularity, as they can help reduce muscle soreness after intense workouts, aid in recovery by constricting blood vessels and decreasing metabolic activity. They may also release endorphins that can improve mood and energy. Red light therapy was also popular with the WHOOP community and helps improve Recovery as it’s believed that red light may increase production of melatonin, ultimately enhancing sleep. A strong Recovery is simple . There’s no need for elaborate Recovery routines or the latest gadgets. Behaviors that helped Recovery this year include strong sleep performance, consuming caffeine and implementing consistent wake times. Behaviors that hinder Recovery are consuming alcohol, having a fever, or excessive Strain. Sex and Recovery: Engaging in sexual activity can contribute to Recovery by reducing stress through the release of endorphins and oxytocin, which may help lower cortisol levels and promote relaxation, potentially leading to improved Recovery scores. The countries where WHOOP members had the most sex in 2023: U.S., Australia, Canada, Denmark, Netherlands Within the U.S., the states where members have the most sex are: Utah, Oklahoma, Alabama, Idaho, Nevada Stress can negatively impact recovery by increasing resting heart rate (RHR) and decreasing heart rate variability (HRV), key indicators WHOOP uses to calculate the Recovery score. Modalities such as breathwork and meditation are top ways WHOOP members managed stress this year. Sleep Hygiene - less can be more, when quality is enhanced. In 2023, WHOOP members didn’t get more sleep, but they found ways to get better sleep. More than half of WHOOP members (52%) tapped WHOOP Coach for individualized recommendations on ways to improve their quality of sleep. When members got morning sunlight, compared to the days they did not, their sleep consistency was higher and they got more sleep, averaging an additional 14 minutes per week. When members practiced daylight eating (consumed all meals during daylight hours), compared to the days they did not, their sleep consistency was also higher and they achieved more quality sleep, averaging an additional 42 minutes per week. Catching zzz's On average, global WHOOP members achieved: Average restorative sleep: 40% Average hours of sleep: 7 Average sleep efficiency: 89% Early birds and Night owls Average bedtime and wake time by country: Earliest bedtime: Australia 10:46 p.m., Latest Qatar 1:50 a.m. Earliest wake time: South Africa 6:40 a.m., Latest Qatar 9:38 a.m. Sleep is cultural: The city that never sleeps is Dubai – but in locations known for nightlife, sleep is also poor (Las Vegas, NV; Miami, FL) Strain - Optimizing Fitness Goes Beyond the Gym When it comes to enhancing performance around Strain and activity, proper nutrition plays a pivotal role. The top 1% of Strain earners (defined as those members with the highest average Strain) log vegetarian, vegan, and kosher diets more than others. On average, these members are the age of 45. WHOOP members reported using more creatine (+41%) as part of their supplement intake. Protein consumption has also seen an increase in 2023 (+38%). Activities with multipurpose benefits are gaining popularity. Rucking targets Zone 2 training , which is done at 60-70% of max heart rate, allowing the body to build an aerobic base, enhancing endurance, optimizing fitness, and unlocking performance gains. It’s typically done outdoors where members also reap the benefits of sunlight. Recreational activities are on the rise as people enjoy team fitness. Those that have seen strong adoption in 2023 include pickleball, soccer, cricket, rugby and paddle tennis. The newest health ambassadors aren’t athletes – they’re performers Stage performance also increased in 2023, with 19% more WHOOP members logging it as a Strain activity year-over-year. Many of the world’s top artists rely on WHOOP to help them choose healthier habits, optimize sleep and travel schedules to be at their best, including record producer, songwriter and DJ Zedd . “Our community achieved a lot in 2023, and we’re confident that WHOOP will help members achieve even more next year,” said Ahmed. “This feature arrives at a perfect time as our members reflect on their goals and get ready to begin 2024 with new ambitions. WHOOP will be there to help.” To access and review the WHOOP Community Year in Review , go to: whoop.com/2023-year-in-review . Individual, personalized Year in Review reports will be available to members in the WHOOP app. Now through December 18, WHOOP is running its Holiday Sale. For a limited time, consumers can take advantage of 10% off prepaid memberships; 12 months for $215 or 24 months for $359. To give the gift of WHOOP this holiday season, go to www.whoop.com . To make it even more convenient than ever before to access WHOOP, it is available for purchase on Amazon.com , as well as at Best Buy and Dick’s Sporting Goods . WHOOP is currently offering a one-month free trial to help everyone start their journey, available at www.whoop.com . ABOUT WHOOP WHOOP, the human performance company, offers a wearable health and fitness coach to help people achieve their goals. The WHOOP membership provides best-in-class wearable technology, actionable feedback, and recommendations across recovery, sleep, training, and health. WHOOP serves professional athletes, Fortune 500 CEOs, executives, fitness enthusiasts, military personnel, frontline workers, and anyone looking to improve their performance. WHOOP Unite is a comprehensive solution dedicated to supporting organizations across a wide range of industries with coaching, organizational insights, and health programs. Studies show WHOOP can positively change behavior, increase sleep, and improve physiological biomarkers. Founded in 2012, WHOOP is based in Boston and has raised more than $400 million in venture capital. The latest round of financing made WHOOP the world's most valuable standalone wearables company. Visit www.whoop.com for more information and connect with WHOOP on Instagram , Twitter , Facebook , LinkedIn , and YouTube .

05 Oct 2023

·www.prnewswire.com

Bizz Energy Is a Clean, Mean Way to Beat the Modern Midday Slump

The Energy Drink Formula Unleashes Unique Levels of Energy Whilst Avoiding Sugar Crashes and Unhealthy Ingredients FORT LAUDERDALE, Fla., Oct. 5, 2023 /PRNewswire/ -- The modern, remote-first work world may not have a consistent nine-to-five rhythm anymore. But that doesn't change the fact that people are still putting a lot of time into working their jobs. The Bureau of Labor Statistics reports that the average American worker clocks in at just over eight hours of labor per day (8.01, to be precise). That means, no matter when those work hours take place, they're going to extend over a significant portion of an individual's daily schedule. It also means it will involve a slump in energy and productivity at some point along the way. "Midday slumps may not always happen in the early afternoon anymore," says Gavin Jacono, founder of Bizz Energy, "But they happen at some point — and on a regular basis. If you start work at four in the morning, chances are you're going to lag after breakfast or in the late morning. If you start at noon, you'll feel tired before dinner." Northwestern Medicine points out that the biggest reason for this energy slump is that it's a predictable part of every individual's circadian cycle. However, the medical site adds that things like sleep disorders, stress, and even poor eating habits can also contribute to a slowdown in the middle of the workday. When that happens, many people turn to energy drinks as a solution — but Jacono points out that traditional energy drink formulas don't really solve the problem. "Those classic formulas use sugar, high fructose corn syrup, or aspartame. They give you a quick boost, but it's often followed by a crash — usually before your work day ends, which only means you're kicking the productivity issue down the road. And your body has to work through all of those unhealthy chemicals and additives, too. That's why we created Bizz Energy. To turn unhealthy, short-term energy drinks into healthy, long-term productivity and health solutions." Bizz Energy replaces unwanted ingredients with healthy alternatives. Each 12 oz can contains a clean shot of 200 mg of caffeine along with a punchy nutritional combination called the SuperTurk® blend. This includes an innovative soluble form of Turkesterone along with creatine, essential amino acids, L-citrulline, L-theanine, L-carnitine, niacin, and biotin. The result of this revolutionary combination is an energy drink that doubles as a nutritional supplement. It helps boost energy without a sugar crash while also stimulating metabolism and helping build muscle and strength. This makes it a clean, mean way to beat a midday slump — no matter when it might take place. About Bizz Energy Bizz Energy was founded by Gavin Jacono. The fitness and nutrition fanatic hails from New York City and is obsessed with boxing, weightlifting, and soccer. As an aspiring 17-year-old entrepreneur, Jacono launched Bizz Energy as a way to create the ultimate energy drink he had always wanted to fuel his athletic pursuits. Along with a potent dose of caffeine, the Bizz Energy formula taps into a unique form of soluble Turkesterone. It is delicious, clean, and effective. Learn more at bizzenergy.com. Media Contact: Gavin Jacono 516-637-8701 [email protected] SOURCE Bizz Energy

04 Aug 2023

·www.prnewswire.com

Bizz Energy Clears Minds and Sharpens Focus

The Clean, Zero-Sugar Energy Drink Is Good For More Than Just Physical Performance. It Boosts Brain Function, Too. FORT LAUDERDALE, Fla., Aug. 4, 2023 /PRNewswire/ -- Bizz Energy is a revolutionary new zero-sugar energy drink designed to boost performance through natural ingredients without the use of harmful chemicals or additives. While this is primarily focused on physical activities, the energy supplement's ingredients can also deliver some helpful benefits for the brain. "I designed Bizz Energy to clear my mind as well as boost my physical performance," explains company founder Gavin Jacono. "Sometimes you need to do more than run faster, lift more, or stay awake longer. Sometimes you need that sharp focus that helps you deliver at work or in school." Bizz Energy helps with cognitive function through multiple natural ingredients. For instance, creatine is a safe brain and body amino acid that has been connected to short-term memory improvement when administered orally. L-citrulline has clearly demonstrated benefits for brain function, as well. L-Theanine relieves stress disorders, improves mood, and helps with sleep. Another ingredient with the potential to help with cognition is Turkesterone. While this popular supplement is currently trending in the sports and fitness world for its physical benefits, there are also suggestions that it could aid mental health by helping cope with stress and fatigue. "Including Turkesterone was a big deal for us," says Jacono. "I knew we wanted it in there, but it's a plant-based steroid, so it isn't water-soluble. We invested in extensive research and testing and were able to develop a method to solubilize Turkesterone — it's one of the most unique things about our product." From carefully selected amino acids to soluble Turkesterone, Bizz Energy is packed with natural ingredients designed to deliver a critical dose of energy when needed. The innovative combination of natural ingredients doesn't just apply to physical performance, either. It can be a game-changer when it comes to cognitive function, too, helping to sharpen the mind and create clear focus. About Bizz Energy Bizz Energy was founded by Gavin Jacono. The fitness and nutrition fanatic hails from New York City and is obsessed with boxing, weightlifting, and soccer. As an aspiring 17-year-old entrepreneur, Jacono launched Bizz Energy as a way to create the ultimate energy drink he had always wanted to fuel his athletic pursuits. Along with a potent dose of caffeine, the Bizz Energy formula taps into a unique form of soluble Turkesterone. It is delicious, clean, and effective. Learn more at bizzenergy.com. Media Contact: Gavin Jacono 516-637-8701 [email protected] SOURCE Bizz Energy

100 Deals associated with Creatine monohydrate

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KEGG	Wiki	ATC	Drug Bank
-	Creatine monohydrate	-	DB00148

R&D Status

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Indication	Highest Phase	Country/Location	Organization	Date
Amyotrophic Lateral Sclerosis	Phase 3	US	Avicena Group, Inc.	01 Jun 2003
Parkinson Disease	Phase 3	-	Avicena LLCStartup	-
Charcot-Marie-Tooth Disease	Phase 1	US	Avicena Group, Inc.	25 Jan 2006
Muscular Dystrophies	Phase 1	US	Avicena Group, Inc.	25 Jan 2006
Angelman Syndrome	Preclinical	US	University of California	01 Dec 2011
Angelman Syndrome	Preclinical	US	National Institutes of Health	01 Dec 2011
Angelman Syndrome	Preclinical	US	Rady Children's Hospital-San Diego	01 Dec 2011

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT04395183 (CTgov)	Phase 2	Depressive Disorder, Major	43	placebo matched to 5-HTP+5-Hydroxytryptophan 100 MG (5-HTP + Placebo)	wexjqnqktq(neqmbfjikv) = gfnoyjszzl cvqqdxpwrg (abycpiswjn, gvxxeugjdr - vkeeyebgut) View more	-	23 Jul 2024
				placebo matched to 5-HTP+Creatine monohydrate (Creatine + Placebo)	wexjqnqktq(neqmbfjikv) = ackrhsctbn cvqqdxpwrg (abycpiswjn, qtazgrpbru - vptvagmlhg) View more
Pubmed \| J Neural Transm (Vienna)	Not Applicable	Bipolar Disorder	35	Creatine monohydrate 6g daily	zcecpxpuwx(ffvpruiiea) = No clinically relevant physical side-effects were reported or observed fgycqknymh (gwdcinlxre ) View more	Positive	01 Feb 2018
				Placebo
NCT02356107 (CTgov)	Phase 4	Hypoxia \| Depressive Disorder, Major \| Depressive Disorder, Treatment-Resistant	15	Creatine monohydrate+5-hydroxytryptophan	pldokqaone(uwhfzwakbh) = ctynzloeto zjmpmbckci (ohnheghqrx, qphaoyjopk - aavmlpfqdx) View more	-	04 Jan 2018
NCT02188849 (CTgov)	Phase 3	Muscle Weakness	50	Resistance exercise training+Creatine (Creatine)	bgtpqcoapi(llmjfrzlso) = cvqnkwlugd yookkhuojq (mrzmpykhua, nxcazlykzd - dzghbrwfef) View more	-	30 Oct 2015
				Resistance exercise training (Placebo)	bgtpqcoapi(llmjfrzlso) = wzqnztkbpx yookkhuojq (mrzmpykhua, lsgaemnuyc - izxmiqiarp) View more
NCT01257581 (SDALS-001, CTgov)	Phase 2	Amyotrophic Lateral Sclerosis	60	creatine (Creatine 30gm)	arpocnbscl(ianhdddydl) = wvvmkuyqft aqadddfohw (iprdklhnal, wiwlnbogwo - vtesoqgspj) View more	-	04 Dec 2014
				Tamoxifen (Tamoxifen 40mg)	arpocnbscl(ianhdddydl) = adlnszfgas aqadddfohw (iprdklhnal, ykueiqrykw - bnustaihuo) View more
NCT01412151 (CREST-X, CTgov)	Phase 2	Hodgkin's Lymphoma \| Huntington Disease	10	Creatine monohydrate	kfwthbihmg(bqupyboibn) = pmputgvwvc ggcsxybwye (cytxreonkv, jazqhnzseq - fqmxjwphcm) View more	-	28 Dec 2012
NCT00348933 (CTgov)	Not Applicable	Angelman Syndrome	90	Metafolin+B12+Creatine+Betaine (Treatment (Metafolin/Creatine/Betaine/B12))	iodpdsbooh(lciajjcnoz) = kjchznmvze wavvhmerub (ndzobpmpcg, ouleqahqic - vbxrfohsls) View more	-	24 Sep 2012
				Metafolin (Treatment (Metafolin/Creatine/Betain/B12))	uxckozoknu(agkzqivtmd) = yftgbfkwbf zwopwkzetu (kvlyuiqdfv, qtsqgytiyp - awggkyecem) View more
SFN2005	Not Applicable	-	-	Creatine	nrosbkcvna(grmojomddd) = gjgcbzwzoj pdggehkfdy (rctnijtxcy )	-	16 Nov 2005
Pubmed \| J Gerontol A Biol Sci Med Sci	Not Applicable	-	-	Creatine monohydrate (CrM) supplementation	bbeekcdheu(fpppubaovt) = hkcktepzjx naxlcfdihs (aticcxtsco ) View more	Positive	01 Jan 2003

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