[Translation] A phase 3, randomized, double-blind study evaluating the efficacy and safety of once-daily oral orforglipron compared with placebo in adults with type 2 diabetes who have inadequate glycemic control on insulin glargine alone or in combination with metformin and/or an SGLT-2 inhibitor (ACHIEVE-5)
本研究旨在确定在甘精胰岛单用或联合二甲双胍和/或 SGLT-2 抑制剂治疗基础上,评估orforglipron与安慰剂相比的获益和风险。本研究将评价3种orforglipron剂量(3mg、12mg和36mg)与安慰剂相比的降糖作用。此外,本研究将比较orforglipron与安慰剂对体重和总体安全性特征的作用。
[Translation] This study aims to determine the benefits and risks of orforglipron compared with placebo, when used alone or in combination with metformin and/or an SGLT-2 inhibitor. This study will evaluate the glucose-lowering effects of three orforglipron doses (3 mg, 12 mg, and 36 mg) compared with placebo. In addition, this study will compare the effects of orforglipron and placebo on body weight and overall safety profile.