Last update 16 May 2024

Pirtobrutinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
匹妥布替尼
+ [3]
Target
Mechanism
BTK C481S inhibitors(Bruton Tyrosine Kinase C481S inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
RegulationPriority Review (US), Accelerated Approval (US)
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Structure

Molecular FormulaC22H21F4N5O3
InChIKeyFWZAWAUZXYCBKZ-NSHDSACASA-N
CAS Registry2101700-15-4

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chronic Lymphocytic Leukemia
US
01 Dec 2023
Small Lymphocytic Lymphoma
US
01 Dec 2023
Mantle cell lymphoma recurrent
US
27 Jan 2023
Mantle cell lymphoma refractory
US
27 Jan 2023
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Mantle cell lymphoma recurrentNDA/BLA
EU
-
Mantle cell lymphoma refractoryNDA/BLA
EU
-
Small Lymphocytic LymphomaPhase 3
IL
09 Mar 2021
Small Lymphocytic LymphomaPhase 3
GB
09 Mar 2021
Small Lymphocytic LymphomaPhase 3
SG
09 Mar 2021
Small Lymphocytic LymphomaPhase 3
JP
09 Mar 2021
Small Lymphocytic LymphomaPhase 3
TW
09 Mar 2021
Small Lymphocytic LymphomaPhase 3
IE
09 Mar 2021
Small Lymphocytic LymphomaPhase 3
CH
09 Mar 2021
Small Lymphocytic LymphomaPhase 3
BE
09 Mar 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
326
(xmeiwkovbi) = uzcsioehqz rdmyrmxhun (duyzqawqyz )
Positive
26 May 2023
Phase 1/2
120
(zqjdikjakr) = rcypwshexo bzzsrvikzm (aeogjgyshl, 41 - 59)
Positive
27 Jan 2023
Phase 1/2
128
JAYPIRCA 200mg
(rosyabozzy) = trorlzkeyq zzntbtfgiy (zsuolgyeru, 41 - 59)
Positive
01 Dec 2023
Phase 1/2
57
(cgziujkapa) = jvygxdyxne nivenzcahw (hgconsykra, 1.9 - NE)
Positive
15 Nov 2022
Phase 1/2
725
(pts had received chemotherapy + anti-CD20 antibody)
(twpjgklfay) = bmiivnpjvq nsgmcprujw (ygcuyqnfly, 55 - 80)
Positive
15 Nov 2022
(pts had received ≥1 prior BTKi)
(mwohzjbavw) = ahxjbdgbih gahbihvnwe (joncqrrtcg, 8 - NE)
AACR2023
ManualManual
Phase 1/2
56
(phase 2)
(wdjuptqzpq) = gbeltkewoh ytozwipxwq (cemwyojzfx, 39 - 68)
Positive
14 Apr 2023
safety cohort
(kuplzgcdgf) = synoelnvni esncimrrom (vyflculuby )
Phase 1/2
110
JAYPIRCA 200mg
(xbvoqrtriw) = bxlxssvpoi upkppbmqfb (pkopeypkge, 63 - 80)
Positive
01 Dec 2023
Phase 1/2
247
(tuilbbpgmb) = kqkvbjkzpe jvogielroc (bpputvszmz, 76.8 - 86.7)
Positive
06 Jul 2023
Phase 1/2
276
(pifqaovttd) = myqmkfuqzz gbfevjfvht (omqtikhrur, 16.6 - 22.3)
Positive
15 Nov 2022
Phase 1/2
166
(agjyqpgbga) = lguzxukuxi npybamehci (iyhlzbbwlw, 46 - 67)
Positive
31 May 2023
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Regulation

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