Zhe Jiang Yi Han Zhi Yao You Xian Gong Si

Primary objective: To study the pharmacokinetics of the test preparation doxycycline hydrochloride tablets (specification: 0.1g, licensed by Zhejiang Yihan Pharmaceutical Co., Ltd.) and the reference preparation doxycycline hydrochloride tablets (trade name: Vibramycin®, specification: 100mg, licensed by Pfizer Japan Inc.) in healthy adult subjects after a single oral administration in fasting and postprandial states, and to evaluate the bioequivalence of the two preparations after oral administration in fasting and postprandial states. Secondary objective: To study the safety of the test preparation doxycycline hydrochloride tablets and the reference preparation doxycycline hydrochloride tablets in healthy adult subjects.