This retrospective clinical trial aims to better explore the potential of large language models in medicine by comparing the effectiveness of MDT consultations conducted by human doctors with those conducted by large language models.
The main questions to be addressed are:
Does using large language models to conduct anthropomorphic MDT consultations yield better results than using non-anthropomorphic processes? Is there a significant performance gap between MDT consultations conducted by large language models and those conducted by humans? How much greater is the economic benefit of MDT consultations from large language models compared to those conducted by humans?
Retrospectively collect MDT consultation records from the past 20 years in northern Sichuan in China, as well as anonymized patient medical records. Group 1: Different large language models are assigned to act as doctors from different departments and as MDT secretaries to summarize consultations. Group 2: The large language model directly outputs diagnostic and treatment recommendations for patients. Compare the outputs of groups 1 and 2 with human performance retrospectively, score them, and select the best model from each department for a re-evaluation through anthropomorphic MDT consultations, once again comparing them to human results.

Start Date01 Oct 2024

Sponsor / Collaborator

North Sichuan Medical College

[+6]

NCT06457269 / CompletedNot ApplicableIIT

Evaluating the Potential of Large Language Models for Respiratory Disease Consultations: A Randomized Crossover Trial

The clinical trial aimes to evaluate multiple large language models in respiratory disease consultations by comparing their performance to that of human doctors across three major medical consultation scenarios.
The main question aims to answer are:
How do large language models perform in comparison to human doctors in diagnosing and consulting on respiratory diseases across various clinical scenarios?
In three clinical scenarios including the online query section, the disease diagnosis section and the medical explanation section, research assistants or volunteers will be asked to cross-question all LLMs or real doctors using predefined online questions and their own issues. After each questioning session, a short washout period is implemented to eliminate potential biases.

Start Date01 Oct 2023

Sponsor / Collaborator

North Sichuan Medical College

[+3]

ChiCTR2300070613 / SuspendedEarly Phase 1IIT

Study on the changes of brain function related to astigmatism axis

Start Date01 May 2023

Sponsor / Collaborator

North Sichuan Medical College

100 Clinical Results associated with North Sichuan Medical College

0 Patents (Medical) associated with North Sichuan Medical College

5,714

Literatures (Medical) associated with North Sichuan Medical College

01 Jan 2025·Journal of Affective Disorders

Post-traumatic growth promotes resilience development: A Longitudinal Mediation Model

Article

Author: Luo, Lanjun ; Li, Siyuan ; Yang, Jianyi ; Wu, Yuze ; Wei, Xuemei ; Li, Fengling ; Shu, Huilan

BACKGROUNDThe frequent occurrence of global disasters poses unprecedented challenges to nursing practice. The frontline nurses in disaster relief are exposed to these events and bear significant levels of stress and psychological distress. Resilience and posttraumatic growth (PTG) are essential protective factors that contribute to sustaining their mental health. The purpose of this study was to determine the directional relationship between resilience and PTG using a cross-lagged design. Furthermore, employing longitudinal mediation to test whether the T1 resilience of frontline nurses would promote the development of T3 resilience through the mediating role of T2 PTG.METHODSA total of 258 frontline nurses were selected as subjects. They completed self-reported measurements in three periods. The present study was conducted using a cross-lagged panel model and a longitudinal mediation model.RESULTSThe results of cross-lagged path analysis from T2 to T3 showed that PTG could positively predict the development of resilience (β = 0.235, p < 0.001). Resilience did not positively predict the development of PTG (p > 0.05). The analysis of mediating effect results showed that the development of PTG at T2 mediated the relationship between resilience from T1 to T3.LIMITATIONSFindings may be limited by self-report, recall bias of resilience before the epidemic and short tracking frequency.CONCLUSIONSThese results can identify individuals with an increased risk of low resilience under disaster and the mediating role of posttraumatic growth in promoting the development of nurses' resilience, which provides a theoretical basis for psychological crisis intervention and the resilience promotion plan for posttraumatic growth under disaster events.

31 Dec 2024·Virulence

Detoxified pneumolysin derivative ΔA146Ply inhibits triple- negative breast cancer metastasis mainly via mannose receptor-mediated autophagy inhibition

Article

Author: Xu, Wenchun ; Wu, Kaifeng ; Zhu, Tao ; Zhang, Hong ; Liu, Bichen ; Yin, Yibing ; Zhang, Xuemei

The detoxified pneumolysin derivative ΔA146Ply has been proven to have a direct anti-triple negative breast cancer effect by our group, but its work model remains unclear. In this study, we focused on its ability to inhibit triple-negative breast cancer metastasis. We found that ΔA146Ply suppressed the migration and invasion of triple-negative breast cancer cells by activating mannose receptor and toll-like receptor 4. Their activation triggers the activation of the mammalian target of rapamycin signalling, sequentially leading to autophagy, transforming growth factor-β1, and epithelial-mesenchymal transition inhibition. Furthermore, the combination of doxorubicin and ΔA146Ply significantly inhibited triple-negative breast cancer progression and prolonged survival in tumour-bearing mice. Taken together, our study provides an alternative microbiome-based mannose receptor-targeted therapy for triple-negative breast cancer and a novel theoretical and experimental basis for the downstream signalling pathway of the mannose receptor.

31 Dec 2024·Virulence

Norepinephrine may promote the progression of Fusobacterium nucleatum related colorectal cancer via quorum sensing signalling

Article

Author: Tian, Qian ; Zeng, Xianghao ; Zhao, Ming ; Zheng, Qiao ; Yan, Li ; Zhang, Ling ; Du, Xinhao ; Tang, Zhenzhen ; Fu, Xiangsheng ; Liang, Lanfan ; Zhao, Xinyu ; Li, Jun ; Hu, Qing

Fusobacterium nucleatum (F. nucleatum) is closely correlated with tumorigenesis in colorectal cancer (CRC). We aimed to investigate the effects of host norepinephrine on the carcinogenicity of F. nucleatum in CRC and reveal the underlying mechanism. The results revealed that both norepinephrine and bacterial quorum sensing (QS) molecule auto-inducer-2 (AI-2) were positively associated with the progression of F. nucleatum related CRC (p < 0.01). In vitro studies, norepinephrine induced upregulation of QS-associated genes and promoted the virulence and proliferation of F. nucleatum. Moreover, chronic stress significantly increased the colon tumour burden of Apc^Min/+ mice infected with F. nucleatum (p < 0.01), which was decreased by a catecholamine inhibitor (p < 0.001). Our findings suggest that stress-induced norepinephrine may promote the progression of F. nucleatum related CRC via bacterial QS signalling. These preliminary data provide a novel strategy for the management of pathogenic bacteria by targeting host hormones-bacterial QS inter-kingdom signalling.

News (Medical) associated with North Sichuan Medical College

07 Aug 2023

·www.drugs.com

Added Sugar Consumption Increases Risk for Kidney Stones

MONDAY, Aug. 7, 2023 -- Consuming added sugars is associated with an increased risk for kidney stones, according to a study published online Aug. 4 in Frontiers in Nutrition . Shan Yin, M.D., from the Affiliated Hospital of North Sichuan Medical College in Nanchong, China, and colleagues examined the association between added sugar and kidney stones in a nationally representative study using datasets from the U.S. National Health and Nutrition Examination Survey for 2007 to 2018. Individuals aged 20 years and older who reported a history of kidney stones and provided recall data on added sugars were included (28,303 adults). The mean energy intake from added sugars was 272.10 kilocalories overall. The researchers found a positive association for the percentage of energy intake from added sugars with kidney stones in the fully adjusted multivariable model. Individuals in the fourth versus the first quartile of added sugar energy intake percentage had a 39 percent higher prevalence of kidney stones. The prevalence of kidney stones was 88 percent higher for those with ≥25 percent calories from added sugar compared with <5 percent. "Further studies are needed to explore the association between added sugar and various diseases or pathological conditions in detail," Yin said in a statement. "For example, what types of kidney stones are most associated with added sugar intake? How much should we reduce our consumption of added sugars to lower the risk of kidney stone formation? Nevertheless, our findings already offer valuable insights for decision-makers." Abstract/Full Text Posted August 2023

Clinical Result

100 Deals associated with North Sichuan Medical College

100 Translational Medicine associated with North Sichuan Medical College

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