Chengdu Better Denuo Pharmaceutical Co., Ltd.

Main research purpose: This study uses progesterone injection (1.112ml:25mg) produced by Chengdu Beitedenuo Pharmaceutical Co., Ltd. as the test preparation and progesterone injection (1.112ml:25mg, trade name: Lubion®) produced by the original IBSA Farmaceutici Italia Srl as the reference preparation to evaluate the bioequivalence of the test preparation and the reference preparation. Secondary research purpose: To observe the safety of the test preparation and the reference preparation in healthy postmenopausal women.

Main research objectives: To investigate the relative bioavailability of a single oral dose of 200 mg (fasting/after meals) of the test preparation ibuprofen suspension (specification: 100 mL: 2 g, produced by Chengdu Betadino Pharmaceutical Co., Ltd.) and the reference preparation ibuprofen suspension (Mei Lin®, specification: 100 mL: 2 g, produced by Shanghai Johnson Pharmaceutical Co., Ltd.) in healthy Chinese subjects, analyze the pharmacokinetic parameters of the two preparations, evaluate the bioequivalence of the two preparations, and provide a reference for the application and clinical use of the drug. Secondary research objectives: To evaluate the safety of a single oral dose of 200 mg (fasting/after meals) of the test preparation and the reference preparation in healthy Chinese adult subjects.

Primary objective: This study used baclofen oral solution (300mL: 0.3g) produced by Chengdu Beitedenuo Pharmaceutical Co., Ltd. as the test preparation and baclofen oral solution (5mg/5mL) (trade name: Lioresal®) marketed in the UK by Novartis Pharmaceuticals UK Ltd as the reference preparation to evaluate the bioequivalence of the test preparation and the reference preparation under fasting and postprandial conditions. Secondary objectives: 1. Observe the safety of the test preparation and the reference preparation in healthy subjects; 2. Evaluate that the taste of the test preparation is not inferior to that of the reference preparation.