Delving into the Latest Updates on The University of Tennessee at Martin with Synapse

Overview

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Immune System Diseases

Hemic and Lymphatic Diseases

Neoplasms

Oncolytic virus

Disease domain score

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Technology Platform

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Targets

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Disease Domain	Count

Neoplasms	1
Immune System Diseases	1
Hemic and Lymphatic Diseases	1

Top 5 Drug Type	Count

Oncolytic virus	1

Top 5 Target	Count

IFNβ(Interferon beta)	1

Body-centered cubic (BCC) refractory compositionally complex alloys (RCCAs) have emerged as promising candidates for aerospace, nuclear energy, and automotive applications due to their exceptional high-temperature strengths.It is well-known that dislocations play a critical role in the mech. properties of refractory alloys.In this study, we examine the fundamental properties of edge and screw dislocations, including core energies and dislocation shear stresses (DSSs) in MoNbTi, NbMoTaW, and CrTaVW, at various temperatures using atomistic simulations with the state-of-the-art machine-learned interat. potentials (MLIPs).Our findings reveal that at high temperatures, the DSS of edge dislocations exceed those of screw dislocations in MoNbTi and NbMoTaW alloys.This behavior is attributed to cross-kink diffusion and annihilation in screw dislocations, which leads to a more significant decrease in DSS as temperature increases.Furthermore, the DSS values of screw dislocations at low temperatures and those of edge dislocations at high temperatures closely align with exptl. yield strengths.These results show that edge dislocations are primarily responsible for the high-temperature strengths of some of the RCCAs and are crucial for tuning their mech. properties.Addnl., we observe that screw dislocations exhibit lower core energies than edge dislocations across all temperatures in the investigated alloys, indicating their greater thermodn. stability.These findings underscore the importance of considering different types of dislocations at various temperature regimes in BCC RCCAs, which is essential for guiding alloy design within the vast compositional space.

100 Deals associated with The University of Tennessee at Martin

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100 Translational Medicine associated with The University of Tennessee at Martin

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Pipeline

Pipeline Snapshot as of 25 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Phase 1 Clinical

1

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

VSV-hIFNbeta-NIS(The University of Tennessee at Martin) ( IFNβ )	Endometrial Carcinoma More	Phase 1
124I-labeled 11-1F4(The University of Tennessee at Martin)	Immunoglobulin Light-Chain Amyloidosis More	Pending