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Neoplasms

Eye Diseases

Skin and Musculoskeletal Diseases

Proteolysis-targeting chimeras (PROTAC)

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A glimpse into the focused therapeutic areas

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Most used technologies in drug development

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Disease Domain	Count

Neoplasms	1
Infectious Diseases	1

Top 5 Drug Type	Count

Proteolysis-targeting chimeras (PROTAC)	1

Top 5 Target	Count

BRD4(Bromodomain-containing protein 4)	1

An Open-label, Single-centre, Two period, crossover, Drug Interaction Study to Assess the Effect of Multiple Oral Administration of Bacosides Enriched Standardized Extract of Bacopa (BESEB) (150 mg BD) on the Pharmacokinetics, Safety and Tolerability of antidiabetic drugs Gliclazide 80mg and Metformin 500mg in Indian Patients With Type 2 Diabetes.

Start Date09 Aug 2016

Sponsor / Collaborator

Csir Food Research Institute

CTRI/2012/08/002850

/ CompletedPhase 3

Evaluation of hepatoprotective effect of Picroliv in patients receiving multi drug therapy for Tuberculosis.

Start Date01 Mar 2005

Sponsor / Collaborator

Csir Food Research Institute

100 Clinical Results associated with Csir Food Research Institute

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0 Patents (Medical) associated with Csir Food Research Institute

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78

Literatures (Medical) associated with Csir Food Research Institute

01 May 2025·International Journal of Biological Macromolecules

Extraction and characterization of chitin and chitosan from molts and Eupolyphaga sinensis Walker: Influence of chemical and ultrasound-assisted enzymatic processing

Article

Author: Wu, Minquan ; Dabbour, Mokhtar ; Ma, Haile ; Mintah, Benjamin Kumah ; Liu, Shuixing ; Liao, Huaijian ; Pan, Jiayin ; Zhang, Shengqi ; He, Ronghai ; Long, Ruiqi ; Huang, Yuanyuan

Chitin was extracted from molts and different life-stages of Eupolyphaga sinensis Walker (ESW) using both chemical and ultrasound-assisted enzymolysis (UAE) methods, followed by deacetylation to produce chitosan. The physicochemical and structural properties of extracted chitosan were characterized and compared with commercially available chitosan (CAC), to validate the methods used. Results illustrated changes in chitosan structure, referencing the growth-stages of ESW, with more significant differences observed between UAE and chemical approaches. UAE method remarkably increased the chitin and chitosan yields, particularly in male nymphs (66.42 %-increase in chitin) and adult males (56.42 %-increase in chitosan), with molts showing the highest chitin (30.49 %) and chitosan (17.16 %). FTIR and XRD spectra indicated that the transmission peaks of the extracted chitosan were consistent with CAC, but the UAE-prepared chitosan (UMC) exhibited higher acetylation (81.00 %-81.82 %) and lower viscosity-average molecular weight compared to chemical method. Scanning electron microscopy showed the surface of ESW chitosan had several pores, whereas the CAC had no voids, implying ESW chitosan possessed higher water- and fat-binding capacity. Furthermore, differential scanning calorimetry analysis showed better homogeneity and thermal stability in UMC. This study suggests that ESW could be used as an alternative source for chitosan production, especially following the application of UAE method.

01 May 2025·Food Research International

Effect of xylose glycation and ultrasonication on the interfacial properties and physicochemical stability of silkworm pupa protein-stabilized Pickering emulsion and its applicability in emulsion-filled hydrogels

Article

Author: Huang, Liurong ; Dabbour, Mokhtar ; Xu, Haining ; Chandrapala, Jayani ; He, Ronghai ; Mintah, Benjamin Kumah ; Dai, Chunhua ; Ma, Haile

Silkworm pupa protein isolate (SPPI) has the potential of being used (as an alternative nutrient) in various food products, but it has poor emulsifying and gelling property. In this study, SPPI was modified by glycation and/or ultrasonication, and the interfacial properties and stability of Pickering emulsions stabilized by SPPI-xylose conjugates and their application in emulsion-filled hydrogels (EFHGs) were investigated. Results showed that, compared with the control, the contact angle of glycated SPPI (using 3 % xylose under ultrasonication, US-X_3%) decreased from 144.6° to 110.9°, and the penetration and rearrangement rates at the water-oil interface increased by 20.76 % and 72.11 %, respectively. Pickering emulsion stabilized by US-X_3% exhibited smaller droplet size, stronger electrostatic repulsion and interfacial pressure, thicker interfacial film, as well as higher elasticity-dominated viscoelastic behavior. After combined treatment, the -20 °C and - 80 °C freeze-thaw stability of SPPI emulsion was increased by 3.78 and 1.62 times, respectively, and the thermal, refrigeration and salt stability were also significantly improved (p < 0.05). By filling the conjugate-stabilized Pickering emulsion (US-X_3%), the content of hydrogen and ionic bonds in EFHGs network was decreased, the hardness and chewiness of the hydrogels were reduced, and the water holding capacity was increased to 95.75 %. The results of gastrointestinal digestion (in vitro) showed that the addition of xylose and the use of sonication had no significant effect on the protein digestibility of EFHGs (p > 0.05). Thus, SPPI-xylose conjugates prepared by glycation and ultrasonication exhibited excellent application potential in emulsion/gel hybrid food system.

01 Jan 2025·Food Chemistry

Stereo-hindrance effect and oxidation cross-linking induced by ultrasound-assisted sodium alginate-glycation inhibit lysinoalanine formation in silkworm pupa protein

Article

Author: Ma, Haile ; Dai, Chunhua ; Xu, Haining ; He, Ronghai ; Huang, Liurong ; Ma, Chunfang ; Pan, Jiayin ; Mintah, Benjamin Kumah ; Dabbour, Mokhtar

Silkworm pupa protein isolate (SPPI) is rich in amino acids, making it chemically reactive, degradable, and easy to form lysinoalanine (LAL). We investigated how conformational cross-linking, induced by ultrasound-assisted sodium alginate, could inhibit the formation of LAL during the preparation of SPPI. Glycoconjugated SPPI (using 1 % sodium alginate under ultrasonication) showed the lowest LAL content i.e., 7.403 μg·mg^-1, representing a 49.58 % decrease, with reference to the control. The ionic, hydrogen, and covalent bonds in the glycoconjugate increased by 171.79 %, 8.48 %, and 35.56 %, respectively. Glycation decreased arginine by 28.92 % and caused the oxidation of tyrosine, methionine and proline to form carbonyl groups. Some precursor amino acids, including lysine, serine, cysteine and threonine were not degraded during the combined treatment. The macromolecular aggregation caused by structural modifications strengthened the steric resistance of LAL cross-linking. The study outcomes provide a novel approach and theoretical basis for inhibition of LAL formation in SPPI.

100 Deals associated with Csir Food Research Institute

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100 Translational Medicine associated with Csir Food Research Institute

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Pipeline

Pipeline Snapshot as of 14 Jun 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

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