Comparison of Multimodal Cocktail Periarticular Injection and Peripheral Nerve Block in Pain Relief After Osteotomy Around the Knee: A Prospective Randomized Controlled Trial - Comparison of Multimodal Cocktail Periarticular Injection and Peripheral Nerve Block in Pain Relief After Osteotomy Around the Knee: A Prospective Randomized Controlled Trial

Start Date21 Jun 2024

Sponsor / Collaborator

Hyogo College of Medicine

JPRN-UMIN000051838 / RecruitingIIT

Effect of Steroid dose Associated with Hematopoietic Stem Cell Transplantation on Fast-twitch Muscle Ratio of Quadriceps Femoris. - Effect of Steroid dose Associated with Hematopoietic Stem Cell Transplantation on Fast-twitch Muscle Ratio of Quadriceps Femoris.

Start Date25 Jul 2023

Sponsor / Collaborator

Hyogo College of Medicine

JPRN-UMIN000053147 / CompletedIIT

The diagnostic ability for hepatic steatosis using Liver Fat Quantification in EPIC(Philips) - The diagnostic ability for hepatic steatosis using Liver Fat Quantification

Start Date01 Oct 2022

Sponsor / Collaborator

Hyogo College of Medicine

100 Clinical Results associated with Hyogo College of Medicine

0 Patents (Medical) associated with Hyogo College of Medicine

13,780

Literatures (Medical) associated with Hyogo College of Medicine

01 Dec 2024·Journal of Infection and Chemotherapy

Validation and development of population pharmacokinetic model of vancomycin using a real-world database from a nationwide free web application

Article

Author: Jono, Hirofumi ; Kawamura, Hideki ; Takahashi, Yoshiko ; Oda, Kazutaka ; Matsumoto, Kazuaki ; Saito, Hideyuki ; Katanoda, Tomomi ; Hashiguchi, Yumi ; Kimura, Toshimi ; Shoji, Kensuke ; Shigemi, Akari ; Takesue, Yoshio

INTRODUCTIONVancomycin requires a population pharmacokinetic (popPK) model to estimate the area under the concentration-time curve (AUC), and an AUC-guided dosing strategy is necessary. This study aimed to develop a popPK model for vancomycin using a real-world database pooled from a nationwide web application (PAT).METHODSIn this retrospective study, the PAT database between December 14, 2022 and April 6, 2023 was used to develop a popPK model. The model was validated and compared with six existing models based on the predictive performance of datasets from another PAT database and the Kumamoto University Hospital. The developed model determined the dosing strategy for achieving the target AUC.RESULTSThe modeling populations consisted of 7146 (13,372 concentrations from the PAT database), 3805 (7540 concentrations from the PAT database), and 783 (1775 concentrations from Kumamoto University Hospital) individuals. A two-compartment popPK model was developed that incorporated creatinine clearance as a covariate for clearance and body weight for central and peripheral volumes of distribution. The validation demonstrated that the popPK model exhibited the smallest mean absolute prediction error of 5.07, outperforming others (ranging from 5.10 to 5.83). The dosing strategies suggested a first dose of 30 mg/kg and maintenance doses adjusted for kidney function and age.CONCLUSIONSThis study demonstrated the updating of PAT through the validation and development of a popPK model using a vast amount of data collected from anonymous PAT users.

01 Nov 2024·Journal of Cardiology

Clinically significant incidental noncardiac findings on preprocedural computed tomography in patients with aortic stenosis undergoing aortic-valve replacement

Article

Author: Yamamoto, Ko ; Taniguchi, Tomohiko ; Minatoya, Kenji ; Isotani, Akihiro ; Shirai, Shinichi ; Kimura, Takeshi ; Takeji, Yasuaki ; Ishizu, Kenichi ; Ohno, Nobuhisa ; Morofuji, Toru ; Kakumoto, Shinichi ; Hayashi, Masaomi ; Tabata, Hiroyuki ; Morimoto, Takeshi ; Ando, Kenji

BACKGROUNDThere is a scarcity of data on the prevalence of abnormal findings on preprocedural computed tomography (CT) before aortic valve replacement (AVR) in patients with aortic stenosis (AS).METHODSAmong consecutive 593 patients with severe AS who were planned to undergo AVR, we evaluated the prevalence of clinically significant incidental noncardiac findings on preprocedural CT. Clinically significant incidental noncardiac findings were defined as newly detected abnormalities that required therapy, consultation for expert, further investigation, or clinical follow-up.RESULTSThe mean age was 82.0 years and 39.5 % of the patients were men. Of those, 78.4 % of the patients were treated with transcatheter aortic valve implantation (TAVI) and 21.6 % of the patients were treated with surgical AVR (SAVR). There were 271 clinically significant incidental noncardiac findings in 227 patients (38.3 %) including 2.5 % of malignancy. The prevalence of clinically significant incidental noncardiac findings were higher in the TAVI group than in the SAVR group (40.2 % versus 31.3 %). The prevalence of clinically significant incidental noncardiac findings were lower in patients under 60 years of age (10.0 %) than in patients over 60 years of age (60-69 years: 40.0 %, 70-79 years: 34.3 %, 80-89 years: 39.7 %, and ≥90 years: 42.1 %).CONCLUSIONSClinically significant incidental noncardiac findings were newly identified on preprocedural CT in approximately 40 % of patients with severe AS undergoing AVR including 2.5 % of malignancy.

01 Nov 2024·Journal of NeuroInterventional Surgery

Comprehensive analysis of the impact of procedure time and the ‘golden hour’ in subpopulations of stroke thrombectomy patients

Article

Author: Matouk, Charles ; Williamson, Richard ; Crosa, Roberto Javier ; Spiotta, Alejandro M ; Tjoumakaris, Stavropoula I ; Dumont, Travis M ; Chalhoub, Reda M ; Liman, Jan ; Levitt, Michael R ; Psychogios, Marios-Nikos ; Cawley, C Michael ; Fargen, Kyle M ; Kan, Peter ; Alawieh, Ali ; Grossberg, Jonathan A ; Polifka, Adam J ; Shaban, Amir ; Fragata, Isabel ; De Leacy, Reade ; Saad, Hassan ; Arthur, Adam S ; Maier, Ilko ; Pabaney, Aqueel ; Yoshimura, Shinichi ; Ash, Makenna ; Al Kasab, Sami ; Jabbour, Pascal ; Howard, Brian M ; Park, Min S ; Wolfe, Stacey Q ; Starke, Robert M ; Dimisko, Laurie ; Samaniego, Edgar A ; Rai, Ansaar T ; Mascitelli, Justin R ; Kim, Joon-Tae

ObjectiveTo evaluate the effect of procedure time on thrombectomy outcomes in different subpopulations of patients undergoing endovascular thrombectomy (EVT), given the recently expanded indications for EVT.MethodsThis multicenter study included patients undergoing EVT for acute ischemic stroke at 35 centers globally. Procedure time was defined as time from groin puncture to successful recanalization (Thrombolysis in Cerebral Infarction score ≥2b) or abortion of procedure. Patients were stratified based on stroke location, use of IV tissue plasminogen activator (tPA), Alberta Stroke Program Early CT score, age group, and onset-to-groin time. Primary outcome was the 90-day modified Rankin Scale (mRS) score, with scores 0–2 designating good outcome. Secondary outcome was postprocedural symptomatic intracranial hemorrhage (sICH). Multivariate analyses were performed using generalized linear models to study the impact of procedure time on outcomes in each subpopulation.ResultsAmong 8961 patients included in the study, a longer procedure time was associated with higher odds of poor outcome (mRS score 3–6), with 10% increase in odds for each 10 min increment. When procedure time exceeded the ‘golden hour’, poor outcome was twice as likely. The golden hour effect was consistent in patients with anterior and posterior circulation strokes, proximal or distal occlusions, in patients with large core infarcts, with or without IV tPA treatment, and across age groups. Procedures exceeding 1 hour were associated with a 40% higher sICH rate. Posterior circulation strokes, delayed presentation, and old age were the variables most sensitive to procedure time.ConclusionsIn this work we demonstrate the universality of the golden hour effect, in which procedures lasting more than 1 hour are associated with worse clinical outcomes and higher rates of sICH across different subpopulations of patients undergoing EVT.

100 Deals associated with Hyogo College of Medicine

100 Translational Medicine associated with Hyogo College of Medicine

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WO2022176901 ( TCR )	Virus Diseases More	Discovery
Iboctadekin ( IL18R1 )	Melanoma More	Discontinued
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P-532 ( thrombin )	Thrombosis More	Pending

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