ObjectiveThe primary objective was to evaluate factors influencing the cost of a ‘hospital at home’ (HAH) for geriatric patients in a Northeastern Mexican hospital. Secondarily to evaluate the per capita global cost-effectiveness compared with traditional hospital care.DesignThis retrospective analysis examined the costs incurred by geriatric patients in an HAH programme from February to December 2022SettingWe collected data from clinical records and assessed medication and procedure costs through the hospital’s financial department. Costs for traditionally hospitalised patients were reviewed for comparison.ParticipantsSubjects of both genders aged 70 and older who were treated in HAH during 2022 and hospitalised subjects with the same age and gender treated in the same period.Intervention: NAPrimary and secondary outcome measuresPrimary outcome: factors that influence costs in HAH. Secondary, global per capita cost comparison between HAH and hospital care.ResultsWe examined the expenses associated with 416 home visits to 49 patients in the HAH programme. The main factors influencing the programme’s overall cost were medical care and procedure-related disorders (β=0.333, p=0.002), sleep-regulators (β=0.561, p<0.001), laxatives (β=0.330, p=0.001) and anticoagulants (β=0.228, p=0.025). The HAH programme’s per capita cost was three times lower compared with that of traditional hospital care and resulted in a 40% reduction in hospitalisation days.ConclusionsThis study highlights that the main factors influencing the HAH programme’s costs include medical care and procedure-related disorders, as well as medication extensively used in the elderly population. Additionally, we demonstrated the cost-effectiveness of the HAH programme, which produces substantial savings and is a financially viable alternative to traditional hospital care.