Gedeon Richter Pharmaceutical (China) Company Limited

To evaluate the effectiveness and safety of estradiol transdermal spray once, twice or three times daily for the treatment of moderate to severe vasomotor symptoms (hot flashes) associated with menopause.

1) To evaluate the human PK characteristics of estradiol in healthy Chinese postmenopausal women after daily administration of 1.7% estradiol transdermal spray 1, 2 or 3 sprays for 10 consecutive days to achieve steady state 2) To evaluate the safety of estradiol transdermal spray in healthy Chinese postmenopausal women after multiple administrations

Preliminary study: healthy female subjects of childbearing age took two preparations orally in a single dose after a high-fat meal, measured blood drug concentration, optimized sampling time according to parameters such as Tmax, and provided a basis for optimizing the formal test plan after a high-fat meal. Formal study: Main research purpose: healthy female subjects of childbearing age took two preparations orally in a single dose after fasting and after a high-fat meal, and evaluated whether the two preparations were bioequivalent in the fasting and high-fat meal states. Secondary research purpose: observe the safety of the subjects.