Feasibility Safety and Early Functional Outcomes of Intra operative Bone Marrow Derived Stem Cell (BMSC) Application Versus Conventional Repair Alone in Nerve Transfer Surgery for Traumatic Brachial Plexus Injury A Randomised Double Blind Pilot Trial - nil

Start Date20 Nov 2025

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Department of Biochemistry

100 Clinical Results associated with University of Wisconsin System

0 Patents (Medical) associated with University of Wisconsin System

2,818

Literatures (Medical) associated with University of Wisconsin System

09 Feb 2026·ACS Biomaterials Science & Engineering

MiRNAs in Interstitial Skin Fluid Sampled with Swellable Hydrogel Microneedles Are Locally Deregulated Near Malignant Skin Lesions in Early Stages of Cutaneous Squamous Cell Carcinoma

Article

Author: Kenaan, Ahmad ; Castellano, Leandro ; Akhavani, Mo ; Ladame, Sylvain ; Strid, Jessica ; Teenan, Oliver ; Sideris, Nikolaos ; Daniels, Connor ; Malaktou, Christina ; Higgins, Claire A.

Interrogating molecular biomarkers in bodily fluids has emerged as a clinically useful strategy for the early diagnosis of many cancer types. Interstitial skin fluid is currently being explored as a possible alternative to blood, containing the same types of biomarkers but lacking cells and debris that hold little or no clinical value. The discovery and validation of molecular biomarkers with diagnostic or prognostic value and the development of clinical tests based on their detection require minimally invasive technologies capable of sampling this fluid in a pain-free manner. Biomarkers must also be easily recoverable for follow-on analysis. Herein, we combine standard genomic approaches with innovative bioengineering technologies to demonstrate that short noncoding miRNAs are significantly deregulated in extracellular skin fluid surrounding malignant skin lesions, providing a yet largely unexplored window of opportunity for early diagnosis of skin cancers. Hydrogel-based microneedle patches offering clinically useful sampling capacity were developed that enable the rapid capture and recovery of endogenous miRNAs from human skin through deformation of the epidermal-dermal junction. Using mouse models of cutaneous squamous cell carcinoma, a significantly greater level of deregulation of selected miRNAs was observed in perilesional skin fluid compared to that in blood levels.

05 Feb 2026·Journal of Physical Chemistry Letters

Stochasticity of Solvent Dynamics: Why Dipoles Emerge Where No Dipoles Are Expected?

Article

Author: Vullev, Valentine I. ; Goddard, William A. ; O’Mari, J. Omar ; Yang, Moon Young

Electric dipoles are ubiquitous, and they are unequivocally important for vital processes in nature and in manmade devices. A recent examination of the dipole dynamics of molecular electrets (i.e., macromolecules with ordered electric dipoles) reveals enormous picosecond fluctuations ranging from 50% to 200% of the average magnitudes. Herein, we demonstrate their universality by exploring the dipole dynamics of aromatic molecules by using polarizable molecular dynamics and quantum mechanical calculations. Explicit solvent implementation leads to not only large fluctuations of the dipoles of polar species, such as coumarin 102, but also the emergence of fluctuating dipoles of nonpolar polycyclic aromatic hydrocarbons (PAHs), such as pyrene and pentacene. For the nonpolar PAHs in polar solvents, the magnitude of the dipole transients reaches up to 5 D. These results demonstrate key paradigms of fluctuating localized electric fields emerging from solvation dynamics with major implications for charge transfer, catalysis, energy conversion, and enzymatic transformations, among other phenomena.

05 Feb 2026·JOURNAL OF PHYSICAL CHEMISTRY B

Synergistic Therapeutic Potential of New Metal-Free Deep Eutectic Solvents: Synthesis, Physicochemical, Biological, and Ab Initio Studies

Article

Author: Cong, Hailin ; Yu, Bing ; Imran, Kashaf ; Adnan, Muhammad ; Ali, Danish ; Yang, Ge ; Sarfraz, Muhammad ; Yaqoob, Asma

A new library of deep eutectic solvents (DESs) was synthesized from the binary combinations of diethylammonium chloride (DEAC), choline chloride (ChCl), glycerol, malonic acid, maleic acid, urea, and niacin across diverse molar proportions by employing either of the thermal- or microwave-assisted routes. Reaction optimization demonstrated that microwave irradiation (30-40 °C, 10-20 s) yielded stable, clear liquids for most of the DEAC:glycerol systems (1:2-1:5), whereas some thermally synthesized maleic acid-urea and malonic acid-DEAC mixtures resulted in rapid postsynthesis solidification, reflecting strong composition-dependent stability constraints. FTIR characterization confirmed DES formation through marked hydrogen bonding, peak broadening, and shifts in the signal positions for more polar O-H, N-H, and C═O bonds. Moreover, a systematic pH profiling across concentration and temperature exhibited well-defined acidity trends, such as malonic-acid- and maleic-acid-based DESs, resulting in strongly acidic aqueous solutions (pH 1.3-2.2), while polyol-based DES solutions in the DEAC:glycerol series remained weakly acidic (pH 4.0-5.3), indicating distinct hydrogen-bond donor/acceptor environments and their sensitivity to aqueous media. The DESs DEAC:glycerol (1:3-1:5) and niacin:urea (1:2) were proved to be the most potent scavengers, exhibiting activity comparable to the reference standard, in antioxidant evaluation. Further, the eutectic combinations DEAC:glycerol (1:3-1:5) (80-100% inhibition at 100 mg/mL; IC₅₀ ≈ 2.0-2.5 mg/mL) demonstrated greater phytotoxicity among the screened DESs, matching the activity of benzofuran, while the DEAC:glycerol (1:2) combination was nontoxic. In antibacterial screening, the DESs DEAC:glycerol (1:3), malonic acid:DEAC (1:1), niacin:urea (1:2), and maleic acid:urea (1:1) resulted in greater activity with inhibition zones of 20-23 mm against E. coli and 20-22 mm against B. subtilis and the IC₅₀ values ranging 0.23-0.50 mg/mL which were comparable to the control, indicating strong intrinsic bioactivity arose from synergistic component interactions. Furthermore, the DFT analyses B3LYP-D3/6-31+G(d,p) corroborated experimental stability trends, thus revealing deep, cooperative hydrogen-bond networks along with low-energy gradient surfaces, which were consistent with persistent noncovalent interactions in the most stable DESs. Collectively, these outcomes establish clear structure-property-bioactivity relationships and provide mechanistic insights into how compositional tuning governs acidity, stability, and biological potency in DES systems.

News (Medical) associated with University of Wisconsin System

03 Apr 2024

·www.prnewswire.com

Jill Schwieters, Herzing University Healthcare Advisory Board Member, Honored with Prestigious Baldrige Leadership Award

Nationally renowned healthcare educator celebrates advisory board member's recognition for leadership excellence. MILWAUKEE, April 3, 2024 /PRNewswire/ -- Herzing University, an accredited, private nonprofit institution focusing on healthcare and nursing degree programs, proudly congratulates Jill Schwieters, an esteemed member of its Healthcare Advisory Board, on being named a recipient of the Baldrige Foundation's Leadership Award for Excellence. This prestigious honor celebrates Schwieters' remarkable contributions to healthcare leadership and innovation. Continue Reading Schwieters, a seasoned healthcare executive and visionary entrepreneur, brings invaluable insights and expertise to Herzing University's Healthcare Advisory Board. Her leadership qualities have not only elevated industry standards but have also inspired innovation and excellence within the healthcare sector. This award is a reflection of our collective commitment to making a meaningful difference. Post this "Jill Schwieters is incredibly deserving of this recognition," said Renee Herzing, president of Herzing University. "As an industry leader, Jill's experience and guidance have been instrumental in helping our teams shape the development of impactful workforce degree programs that resonate with the next generation of healthcare workers. Her expertise and that of her fellow board members continues to play a crucial role in elevating the national status of Herzing University as a workforce solutions provider and maintaining a competitive edge in training future nurses and healthcare professionals." Through Schwieters' involvement, the Board has been able to add its input into emerging trends like workforce training, artificial intelligence, and the utilization of other emerging technologies across the field of healthcare, helping Herzing to navigate how such skills can positively affect future employers and industry challenges. This inside knowledge plays a pivotal role in enriching the educational experience for students pursuing new career paths or expanding their existing skillsets within one or more of Herzing's degree programs, including their hybrid and online programs. "Jill Schwieters' receipt of the Baldrige Foundation's Leadership Award is a testament to her innovative approach to healthcare leadership and her passion for driving positive change in the industry," said Anne Ballentine, vice president of marketing and communications at Rogers Behavioral Health and fellow member of Herzing's Healthcare Advisory Board. "Her effectiveness across her professional career connects directly with her expert understanding of healthcare employers' evolving needs. I see Jill as a highly skilled leader working to strengthen our healthcare landscape in a rapidly changing environment." Schwieters brings a wealth of experience and expertise to Herzing Healthcare Advisory Board. From participating in the Harvard Business School's YPO President's Program and with a MSM degree from Cardinal Stritch University and BS from the University of Wisconsin – Stevens Point, her distinguished career spans various leadership positions across healthcare including: Senior Managing Director of Surgical Directions, driving organizational strategy, fostering strategic partnerships, and instilling a focus on service excellence. Founder and President of Cielo Healthcare, achieving over $100 million in annual revenue and delivering innovative and transformative results for clients. Nearly 15 years of service at the Wheaton Franciscan Health System, providing her with a strong foundation for the business of healthcare and shaping her passion for innovation and improving healthcare for patients and employees. Board Chair of the National Center for Healthcare Leadership partnering with member organizations across the country with a focus on leadership development and international access. "The Baldrige Foundation's Leadership Award is a worldwide standard with an important focus on quality and excellence," Schwieters said. "I am honored to be recognized and appreciate the opportunity to share this recognition with other leaders. This award is a reflection of our collective commitment to making a meaningful difference." The Baldrige Foundation's Leadership Awards ceremony will be held as part of the annual Quest for Excellence® conference near Washington, D.C. on April 9, 2024, where Schwieters will be formally recognized for her outstanding leadership. ABOUT HERZING UNIVERSITY Herzing University is an accredited, private nonprofit institution with 11 campuses across eight states and an online division. Founded in 1965 and headquartered in the heart of Milwaukee, more than 40,000 students have graduated from the University's career-focused and flexible master's, bachelor's, and associate degree, and diploma programs. Fields of study include nursing and a Doctor of Nursing Practice (DNP) program through Herzing's School of Nursing, as well as programs across healthcare, technology, business, and public safety. Since 2013, U.S. News & World Report has recognized Herzing University annually for having some of the nation's top online programs. Herzing University is accredited by the Higher Learning Commission. More information about Herzing University is available at . Herzing University's Healthcare Advisory Board is a national body of healthcare industry leaders who advise Herzing on current and emerging trends in the healthcare industry impacting workforce needs. The Board, with its diverse expertise and experience, reviews and advises Herzing on its program offerings, curriculum, outreach and communication strategies to address evolving student and community needs. Additionally, the Board serves to build and extend Herzing's sphere of influence to improve educational access and workforce development. Members of Herzing's Advisory Board include Anne Ballentine, Carrie Harris-Muller, Jill Schwieters, J.B. Hill, Mark Ambrosius, Paula Just, Scott Reid, Tim Rice, and Dr. Andrea Wills. Contact: Brett Gerrish 517-899-7795 [email protected] SOURCE Herzing University

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Pipeline Snapshot as of 08 Mar 2026

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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Drug(Targets)	Indications	Global Highest Phase

Allogeneic cultured keratinocytes and dermal fibroblasts in murine collagen-dsat(Stratatech)	Burns More	Phase 3
HUB-101 ( Kir7.1 )	Leber Congenital Amaurosis More	Preclinical
NOX-151	Endothelial dysfunction More	Pending
BN-50739 ( PAF receptor )	Stroke More	Pending

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