Constellation Pharmaceuticals, Inc.

Booster Therapeutics raises $15 million seed financing led by Apollo Health Ventures and Novo Holdings Booster Therapeutics’ proteasome activation approach designed to achieve wider degradation of harmful proteins than current targeted protein degraders Harmful protein accumulation implicated in range of complex diseases also linked to proteasome dysfunction COPENHAGEN, Denmark I October 10, 2024 I Novo Holdings, a leading global life sciences investor, today announced the launch of Booster Therapeutics (Booster / the Company), a biotechnology company developing a new class of proteasome activator medicines to treat neurodegenerative and other diseases. The launch is accompanied by a $15 million seed financing round led by Apollo Health Ventures and Novo Holdings. Novo Holdings will play a central role in helping to further build Booster in its next phase of growth, bringing hands-on operational expertise, strategic guidance and helping the Company access a larger network of talent. Novo Holdings will further leverage the expertise in its group of entrepreneurs-in-residence, as well as the Seed Lab wet-lab capabilities in Copenhagen, Denmark. Proteasomes play an important role in the clearing of dysfunctional proteins. Booster is leading a new field of protein degradation via small molecules that activate and restore the function of 20S proteasomes. These proteasomes naturally and directly recognise and degrade a wide range of misfolded or otherwise damaged proteins in contrast to conventional protein degradation therapeutics, which only degrade one target protein at a time. Activation of the 20S proteasome can remove a wide range of disease-causing proteins and thus address more complex diseases caused by multiple concurrent proteinopathies. With a vision of a multi-disease pipeline, Booster will initially focus on major neurodegenerative diseases such as Parkinson’s and Alzheimer’s. This group of diseases generally carries a tremendous burden of disease for patients, families and the healthcare system due to their progressive and severe nature and a lack of disease-modifying therapeutics. Booster was founded by the pioneering work of Dr. Diogo Feleciano and University of California Irvine Professor Dr. Darci Trader, as part of the company creation efforts of Apollo Health Ventures. The Company was built on the idea that small molecules could be used to trigger natural proteasome processes. Their DGRADX™ platform, which was conceived in Prof. Trader’s laboratory, combines proprietary methods for automated high-throughput screening with advanced structural and computational tools to develop Booster’s novel proteasome activator compounds. “Proteasome activation is a truly novel concept because it can potentially transform how we address some of the most multi-factorial diseases. Booster’s deep expertise in proteasome biology means it is well positioned to deliver on first-in-class medicines and expand the protein degradation landscape to more comprehensively address protein dysfunction and impact more disease areas,” said Dr. João Ribas, Principal at Novo Holdings, Seed Investments and Interim Chief Business Officer and Board Member, Booster Therapeutics. “We’re excited to join efforts with Apollo and the Booster team in order to take this novel therapeutic concept forward for the benefit of patients.” The Company and corporate strategy will be led by Dr. Diogo Feleciano as Chief Scientific Officer and Dr. João Ribas as interim Chief Business Officer. Dr. Patrick Trojer, Co-Founder of Constellation Pharmaceuticals and current Chief Executive Officer & President of TRIANA Biomedicines will serve as Chair of Booster’s Board of Directors. About Booster Therapeutics Booster Therapeutics is pioneering a new class of medicines that activate the cell’s natural quality control machinery to treat a range of complex indications. Booster’s small molecule therapeutics, discovered through the DGRADX™ platform, are designed to directly boost the activity of 20S proteasomes to restore the body’s ability to clear disease-causing proteins. The Company is developing a multi-disease pipeline, with an initial focus on neurodegenerative diseases associated with impaired proteasome function such as Parkinson’s disease and Alzheimer’s disease. Booster is based in Berlin, Germany. For more information, visit www.boostertx.com About Novo Holdings A/S Novo Holdings is a holding and investment company that is responsible for managing the assets and the wealth of the Novo Nordisk Foundation. The purpose of Novo Holdings is to improve people’s health and the sustainability of society and the planet by generating attractive long-term returns on the assets of the Novo Nordisk Foundation. Wholly owned by the Novo Nordisk Foundation, Novo Holdings is the controlling shareholder of Novo Nordisk A/S and Novonesis A/S and manages an investment portfolio with a long-term return perspective. Novo Holdings is a world-leading life sciences investor. Through its Seed, Venture, Growth, Principal Investments, Planetary Health Investments and Asia teams, Novo Holdings invests directly in life science companies at all stages of development. In addition, it manages a broad portfolio of Capital Investments, including equities, bonds, fixed income, real estate, and infrastructure assets. As of year-end 2023, Novo Holdings had total assets of EUR 149 billion. www.novoholdings.dk SOURCE: Novo Holdings

PRESS RELEASE EnnoDC unveils the next generation of dendritic cell-targeting immunotherapies supported by new leadership and an evolved strategy Versatile new technology featuring an antibody fused with an antigen, harnesses the power of immunotherapy and vaccines by stimulating dendritic cells through CD40 to deliver a targeted and effective immune response for cancer and infectious diseasesNew approach aims to reduce harmful side effects and optimize the immune system's ability to detect, combat, and prevent cancer and infectious diseases Dr. Jean-Paul Kress, former Chief Executive Officer of MorphoSys, joins as Board Chairman; Christophe Hubert, industry veteran and entrepreneur joins as Chief Executive Officer; with co-founder Prof. Yves Levy, as Chief Medical and Scientific Officer and Dr. Hatem Azim joining as Chief Medical Officer Oncology Paris, France, 26 September 2024 – EnnoDC (or “the Company”), a clinical-stage biotech company pioneering the development of first-in-class dendritic cell-targeting immunotherapies, unveils today its promising pipeline of preclinical and clinical-stage programs for cancer and infectious diseases. EnnoDC’s technology, developed by the Vaccine Research Institute (VRI) of Inserm (French National Institute for health and Medical Research) and its spin-off LinKinVax, combines an antibody fused with an antigen to stimulate Dendritic Cells (DCs) through CD40 and deliver a targeted and effective immune response. The technology has already entered clinical development in the field of infectious diseases. EnnoDC is now extending the use of its technology to expand its portfolio of immunotherapies to fight cancers. EnnoDC is one of the innovative projects selected and supported by the Paris Saclay Cancer Cluster, whose mission is to accelerate the development of innovation in oncology. Immunotherapies, which enable a patient’s immune system to recognize and target cancer cells, have made a significant difference to cancer patients over the last decade. However, many patients fail to mount a robust and durable immune response, resistance can develop, and immune-related adverse events and systemic toxicity can be severe. DCs are crucial for the development of immune memory to identify and eliminate threats such as viruses and cancer. They form the basis of EnnoDC’s first-in-class immunotherapy platform by directly targeting DCs through a unique anti-CD40 antibody fused with tumor-specific or a pathogenic antigen, driving a highly specific immune response. EnnoDC’s evolution is accompanied by a change of leadership with the appointment of Christophe Hubert as the new Chief Executive Officer. Christophe is an international business executive and biotech entrepreneur, with over 25 years’ experience in the pharmaceutical and biotech industry. He previously served as SVP of Asia Merck and was the founder of three biotech companies. Christophe Hubert, Chief Executive Officer of EnnoDC, commented: “I am honored to lead the team at EnnoDC as it pioneers the development of the next generation of immunotherapies for cancer and infectious diseases. This is a fantastic opportunity to translate some of the best research within the immunotherapy space into meaningful change for patients.” Dr Jean-Paul Kress has joined EnnoDC as its Chairman of the Board and brings over 25 years of experience driving transformative change in the biotech and pharmaceutical industries. As the former CEO of MorphyoSys, he has completed two significant transactions: the acquisition of Constellation Pharmaceuticals in 2021 and the acquisition of MorphoSys by Novartis in 2024. Dr. Jean-Paul Kress, Chairman of EnnoDC added: “My time at MorphoSys has given me a deep appreciation of the complexities and challenges of developing effective treatments for cancer. EnnoDC’s new technology at the forefront of medicine drew me to the role of Chairman as I see great promise in the scientific approach which has already shown promise in the clinic. I look forward to working with the Board and management.” Dr Hatem Azim has also joined EnnoDC as the Chief Medical Officer Oncology and is an expert in cancer and drug development. His previous research focused on breast cancer and early drug development, with his contributions shaping international guidelines. This new clinical oncology expertise will be particularly useful with EnnoDC’s additional focus on developing immunotherapies for cancer. Pr. Yves Lévy, co-founder, Chief Medical and Scientific Officer at EnnoDC concluded: “Clinical progress and technological development over the last ten years in the fields of infectious diseases and cancer in an academic laboratory like the Vaccine Research Institute (VRI), supported by its supervisory authorities, is a source of great pride for all researchers. However, challenges remain immense and we are aware of this. The environment and resources provided by EnnoDC will be essential to succeed for the benefit of patients.” EnnoDC has an extensive pipeline of clinical and preclinical stage assets in HPV-induced cancers, prostate cancer and in infectious diseases. A Phase I/II clinical trial with CD40.HVac is currently running in 24 HPV16+ oropharyngeal cancer patients at Gustave Roussy Cancer Campus and Curie Institute in France. EnnoDC is planning to initiate in Q2 2025 a Phase IIb in HPV16+ oropharyngeal cancer patients and is planning a pre-IND filing for a Phase I/IIa trial in prostate cancer early 2027. A Phase I/IIa clinical trial for a prophylactic COVID-19 vaccine is ongoing and a Phase I clinical trial with a HIV vaccine has been completed. * EnnoDC is the trading name of LinKinVax Europe SAS. -Ends- For more information please contact: EnnoDC Christophe Hubert, CEOinfo@EnnoDC.com ICR Consilium Ashley Tapp / Jonathan Edwards / Kumail Waljee EnnoDC@consilium-comms.comTel: +44 (0) 20 3709 5700 About EnnoDC EnnoDC, the trading name of LinKinVax, is a clinical-stage biotech company pioneering the development of first-in-class Dendritic Cell (DC)-targeting immunotherapies. Through our versatile DC-targeting immunotherapy platform we are developing CD40-specific monoclonal antibodies fused with pathogenic antigens to induce a highly specific, safe, broad, and long-lasting immune response to combat diseases like cancer and infectious diseases. The Company currently has three active clinical trials in various stages of clinical development, addressing oncology and infectious disease indications. Its lead asset, CD40HVac is currently in a Phase I/IIa clinical trial for HPV16+ oropharyngeal cancer patients. EnnoDC is a spin out from the Vaccine Research Institute (VRI), an institute of INSERM (the French National Institute of Health and Medical Research) and is supported by longstanding investors and internationally renowned key opinion leaders who contribute their expertise in the clinical development of EnnoDC’s assets and help explore the expansive therapeutic potential of its innovative platform. Find out more online at: http://www.EnnoDC.com Follow us on X and LinkedIn

New appointment brings global financial and operational experience in life sciences to support continued advancement of ReAlta’s EPICC Technology Platform NORFOLK, Va.--(BUSINESS WIRE)-- ReAlta Life Sciences, Inc. (“ReAlta” or the “Company”), a mid-stage clinical biotech company dedicated to saving lives by rebalancing the inflammatory response to address life-threatening diseases, today announced the appointment of Emma Reeve to its Board of Directors, effective immediately. “We are very pleased to welcome Emma Reeve to our Board of Directors,” said Buzz Heidt, Chairman of ReAlta’s Board of Directors. "As ReAlta continues to advance our programs towards commercial launch in markets around the world, Emma's diverse global experience and deep knowledge of capital markets and financial strategies will help guide and strengthen our plans to deliver novel therapies to the patients that urgently need them.” “I am impressed with the remarkable progress ReAlta has made to advance multiple programs into the clinic,” said Ms. Reeve. “I am excited to take on this role and contribute to the company’s mission to address life threatening acute inflammatory and rare diseases.” Emma Reeve Emma Reeve is an accomplished biopharmaceutical executive with more than 30 years of global financial experience across pharmaceutical, medical device, and bio-pharma companies. Most recently, Ms. Reeve served as Chief Financial Officer of Constellation Pharmaceuticals, Inc., a development-stage oncology company, prior to its acquisition by MorphoSys AG in 2021. She led Constellation’s IPO in 2018. Prior to Constellation, Ms. Reeve acted as interim Chief Financial Officer and Corporate Controller of Parexel International, a global biopharmaceutical services company, where she was responsible for all aspects of finance, investor relations, procurement, and facilities. In this role, she led the finance aspects of a sell-side process which culminated in an agreement to take the company private in a $5 billion leveraged buy-out. Earlier in her career, Ms. Reeve served as Chief Financial Officer of both Inotek Pharmaceuticals and Aton Pharma. Additionally, she held senior finance and operational roles at Bristol Myers Squibb, Merck, and Novartis. Ms. Reeve is currently Chair of the Board of Editas Medicine and serves on the Board of PTC Therapeutics and Aadi Bioscience, all public biotechnology companies. In addition, she serves on the Board of Directors for Cardurion Pharma. Ms. Reeve holds a B.Sc. in computer science from Imperial College, University of London and is an associate of the Institute of Chartered Accountants in England and Wales. About ReAlta Life Sciences ReAlta Life Sciences, Inc. is a mid-stage clinical biotech company dedicated to saving lives by rebalancing the inflammatory response to address life threatening acute inflammatory and rare diseases. The Company’s EPICC peptides are based on research into the human astrovirus, HAstV-1, which causes a non-inflammatory, self-limiting gastroenteritis unique among viruses by inhibiting components of the innate immune system. ReAlta’s therapeutic peptides leverage these virus-derived mechanisms to rebalance complement and inflammatory processes in the body. The company’s pipeline is led by RLS-0071, which has received IND clearance by the U.S. Food and Drug Administration (FDA) for the treatment of acute exacerbations of chronic obstructive pulmonary disease and acute graft-versus-host disease, and IND clearance, Orphan Drug Designation, and Fast Track Designation by the FDA, and Orphan Drug Designation by the European Medicines Agency, for the treatment of hypoxic-ischemic encephalopathy (HIE). The company launched in 2018 and is located in Norfolk, Virginia. For more information, please visit . View source version on businesswire.com: Contacts Media and Investor Contact: John Rickman Chief Financial Officer jrickman@realtals.com Source: ReAlta Life Sciences View this news release online at: