Research directed toward reducing lost compaction functionality of microcrystalline cellulose (MCC) after wet granulation led to the development of a new excipient known as silicified microcrystalline cellulose. This material exhibits improved compactibility in direct compression or after wet granulation, as well as better flow. This article discusses the enhanced functional benefits of the 2 com. grades of this excipient, which is prepared by co-processing MCC with colloidal silicon dioxide.