Delving into the Latest Updates on Shanghai Tuojie Biotechnology Co., Ltd. with Synapse

Overview

Tags

Endocrinology and Metabolic Disease

Neoplasms

Cardiovascular Diseases

Small molecule drug

Oligonucleotide

Chemical drugs

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Endocrinology and Metabolic Disease	14
Neoplasms	7
Immune System Diseases	4
Nervous System Diseases	2
Hemic and Lymphatic Diseases	2
Infectious Diseases	1

Top 5 Drug Type	Count

Small molecule drug	25
Oligonucleotide	5
Chemical drugs	4
siRNA	3

Top 5 Target	Count

KHK(ketohexokinase)	2
PCSK9(Proprotein convertase subtilisin kexin type 9)	1
BCKDK(branched chain keto acid dehydrogenase kinase)	1
CDK7(Cyclin-dependent kinase 7)	1
CaSR(Calcium sensing receptor)	1

主要目的：评价治疗28周后，HRS-7249与安慰剂相比，在高脂血症患者中降低TG的有效性。次要目的：评价治疗28周和48周后，HRS-7249与安慰剂相比，在高脂血症患者中改善血脂指标的有效性、预防急性胰腺炎的有效性、降低糖化血红蛋白的有效性；评价HRS-7249与安慰剂相比，在高脂血症患者中的安全性、群体药代动力学和药效学特征、免疫原性。

[Translation]

Primary objective: To evaluate the effectiveness of HRS-7249 in reducing triglycerides (TG) in patients with hyperlipidemia after 28 weeks of treatment compared with placebo. Secondary objectives: To evaluate the effectiveness of HRS-7249 in improving lipid profiles, preventing acute pancreatitis, and reducing glycated hemoglobin in patients with hyperlipidemia after 28 and 48 weeks of treatment compared with placebo; and to evaluate the safety, population pharmacokinetic and pharmacodynamic characteristics, and immunogenicity of HRS-7249 in patients with hyperlipidemia compared with placebo.

Start Date-

Sponsor / Collaborator

Shanghai Tuojie Biotechnology Co., Ltd.

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100 Clinical Results associated with Shanghai Tuojie Biotechnology Co., Ltd.

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0 Patents (Medical) associated with Shanghai Tuojie Biotechnology Co., Ltd.

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100 Deals associated with Shanghai Tuojie Biotechnology Co., Ltd.

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100 Translational Medicine associated with Shanghai Tuojie Biotechnology Co., Ltd.

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Pipeline

Pipeline Snapshot as of 04 Sep 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

12

5

Preclinical

IND Application

1

13

Phase 1

Phase 2

6

4

Other

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

TJ-032	Neoplasms More	Phase 2
HRS-5346 ( Lp(a) )	lipoprotein Disorder More	Phase 2
TJ-062	Metabolic Diseases More	Phase 2
HRS-7249	Hyperlipidemias More	Phase 2
TJ-040	Hepatitis, Chronic More	Phase 2