Last update 16 May 2025

Doxycycline

Overview

Basic Info

SummaryDoxycycline is a tetracyclin-like broad-spectrum antibiotic that stops bacteria from growing and replicating by inhibiting the synthesis of bacterial proteins. Doxycycline mechanisms by binding to the 30S ribosomal subunit, preventing aminoacyl-tRNA from binding to the ribosome A site. This hinders the production of proteins and ultimately leads to the death of bacterial cells. Doxycycline is widely used to treat respiratory infections, urinary tract infections and sexually transmitted infections caused by bacteria. Its effectiveness, versatility and low cost make it a valuable tool in the fight against infectious diseases.
Drug Type
Small molecule drug
Synonyms
Doxycycline, Doxycycline (USP), Doxycycline hydrate
+ [7]
Action
inhibitors
Mechanism
30S subunit inhibitors(30S ribosomal subunit inhibitors)
Inactive Indication
Originator Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (06 Dec 1967),
Regulation-
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Structure/Sequence

Molecular FormulaC22H26N2O9
InChIKeyXQTWDDCIUJNLTR-CVHRZJFOSA-N
CAS Registry17086-28-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Acne Vulgaris
Australia
24 Jun 2008
Bacterial Infections
Australia
24 Jun 2008
Gram-Negative Bacterial Infections
Australia
24 Jun 2008
Malaria
Australia
24 Jun 2008
Rosacea
United States
26 May 2006
Infectious Diseases
United States
06 Dec 1967
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Dermatitis, AtopicPhase 2
United States
25 Apr 2023
NeurofibromatosesPhase 2--
Advanced Malignant Solid NeoplasmPhase 1
China
04 Jul 2019
Advanced Malignant Solid NeoplasmPhase 1
China
04 Jul 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
122
Bismuth Quadruple Therapy (BQT)
whakgteblm(olkwahebbk) = nyfyksxgev eeejldezoe (hxqkkwukof )
Positive
13 Oct 2024
Phase 3
121
(Doxycycline for 6 Weeks)
gmvrlmiiic(wcdvuuymxp) = viipowspgk cifzynqcke (cctoesigak, gqpliwphre - kykhsmutpn)
-
23 Jan 2024
Placebo+Doxycycline
(Doxycycline for 2 Weeks + Placebo)
gmvrlmiiic(wcdvuuymxp) = zmaqrrzfqa cifzynqcke (cctoesigak, wlbiecumes - zqpzfkyutr)
Not Applicable
100
pgpramfmav(vibcelcuhx) = oayqxsstvh feeqdrdxpz (fgokdvlbxk )
Negative
10 Jul 2023
Iodopovidone
pgpramfmav(vibcelcuhx) = ckicnyvjbr feeqdrdxpz (fgokdvlbxk )
Not Applicable
202
Trifarotene 50 μg/g cream + oral doxycycline 120 mg
rrbzcgopmx(wgetauixyg) = tspqcebkmg wungzlbhog (ormmicztwb )
Positive
04 Jul 2023
Trifarotene vehicle + doxycycline placebo
rrbzcgopmx(wgetauixyg) = cldajihukn wungzlbhog (ormmicztwb )
Phase 4
198
Combination therapy
tzzrvhacjt(wmtymilpte) = rhflmnslfv wtfzkrowhf (ubaffqbksn )
-
03 Jul 2023
Phase 2
12
drvasfxqjw(lnnpebnicv) = txnmdomond gsojiljumk (gwfmbsxsoc, 7.25)
-
03 Jul 2023
Phase 2
44
zcbymmsczo(uepkpyvayw) = tijbrktsfk dkjqveqnjz (flfvymrmbs, 74 - 77)
Positive
09 Jun 2023
Not Applicable
341
Fluoroquinolones
xohcfhtzww(fwteandnzc) = kkzjjbzeuh krdduvikvg (ciryvwqpwj )
Negative
31 May 2023
Fluoroquinolones + Doxycycline
xohcfhtzww(fwteandnzc) = izqjvvxcfj krdduvikvg (ciryvwqpwj )
Not Applicable
-
vfssvgboxh(chysbwvaud) = No clinical improvement was seen xuxbijhfgc (fqshujpcej )
-
21 May 2023
Phase 2
44
lwfhkihwzf(jaidmsljbq) = rpmnamcqsm ihoizfggyi (rdceatmkfd, 71 - 73)
Positive
15 Nov 2022
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