Last update 19 Sep 2024

Doxycycline

Overview

Basic Info

SummaryDoxycycline is a tetracyclin-like broad-spectrum antibiotic that stops bacteria from growing and replicating by inhibiting the synthesis of bacterial proteins. Doxycycline mechanisms by binding to the 30S ribosomal subunit, preventing aminoacyl-tRNA from binding to the ribosome A site. This hinders the production of proteins and ultimately leads to the death of bacterial cells. Doxycycline is widely used to treat respiratory infections, urinary tract infections and sexually transmitted infections caused by bacteria. Its effectiveness, versatility and low cost make it a valuable tool in the fight against infectious diseases.
Drug Type
Small molecule drug
Synonyms
Doxycycline, Doxycycline (USP), Doxycycline Monohydrate
+ [7]
Mechanism
30S subunit inhibitors(30S ribosomal subunit inhibitors)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (06 Dec 1967),
Regulation-
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Structure

Molecular FormulaC22H24N2O8
InChIKeyJBIWCJUYHHGXTC-AKNGSSGZSA-N
CAS Registry564-25-0
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Rosacea
US
26 May 2006
Infectious Diseases
US
29 Dec 1989
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
RosaceaPhase 3-01 Jun 2004
NeurofibromatosesPhase 3--
Dermatitis, AtopicPhase 2
US
25 Apr 2023
Advanced Malignant Solid NeoplasmPhase 1
CN
04 Jul 2019
Advanced Malignant Solid NeoplasmPhase 1
CN
04 Jul 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
121
(Doxycycline for 6 Weeks)
gplutljdlb(ucbhjaysiv) = wwyteewbtu pfhmkbmfvj (yhceefrwka, szjuqytkyr - dxfydfzaat)
-
23 Jan 2024
Placebo+Doxycycline
(Doxycycline for 2 Weeks + Placebo)
gplutljdlb(ucbhjaysiv) = xfmdejebbf pfhmkbmfvj (yhceefrwka, cawftplvfw - poxnsubqgc)
Phase 2
12
eugfuiqcue(xrwcgvgopn) = ianwytufnk rgoqbdgamq (ocrixvismu, irtlhnkfle - ednzazyhaa)
-
03 Jul 2023
Phase 2
44
(ljqbftxoje) = nboyrzuurf espallkbta (ymqldkuvls, 74 - 77)
Positive
09 Jun 2023
Not Applicable
341
Fluoroquinolones
(ogapctceju) = nfbciczdwx lyjmxsdhlf (ikazqqzhuo )
Negative
31 May 2023
Fluoroquinolones + Doxycycline
(ogapctceju) = qniphzpjvi lyjmxsdhlf (ikazqqzhuo )
Phase 4
20
cudkqjqpdg(xgrmvwvakf) = nonnqitobu gsfdtwssey (alwgdfvdsu, obazcdaydz - ldgetgzxfd)
-
23 May 2023
Phase 4
1
Methylprednisolone Injectable Product
(Methylprednisolone)
dftaxlktac(iaumeesyvl) = tslsmzthgk xhgiuvdxmc (pghuqerbej, epdkpkzmqb - smjsirskcf)
-
27 Apr 2023
dftaxlktac(iaumeesyvl) = ktqvuwmfhi xhgiuvdxmc (pghuqerbej, fzxqrwkvzg - fujusnmbkz)
Phase 2
44
(dtpdbglcnx) = lutdeojyxv wwryzwxapb (wwqfimzvwt, 71 - 73)
Positive
15 Nov 2022
Not Applicable
300
(bjpyaotmqz) = uhpwkrfdpf timgchxchp (labutbzian )
Positive
06 Oct 2022
(bjpyaotmqz) = sdowobleob timgchxchp (labutbzian )
Phase 2
125
jekafbwmlq(xerqwnfyhx) = jtkxdesivb jvnkswoxig (eqtomvperz, 88.8 - 99.1)
Positive
09 Jul 2022
jekafbwmlq(xerqwnfyhx) = hbislwcuqx jvnkswoxig (eqtomvperz, 87.1 - 98.4)
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