The First Hospital of Harbin Medical University

As one of the three major malignant tumors in women, the morbidity of endometrial cancer is second only to that of cervical cancer and is increasing yearly. Its etiological mechanism is not clear, and the risk factors are numerous and common and are closely related to obesity, hypertension, diabetes, etc. The gut microbiota has many strains, which play a considerable part in normal digestion and absorption in the human body and the regulation of the immune response. In the last few years, research on the gut microbiota has been unprecedentedly popular, and it has been confirmed that the gut microbiota closely correlates with the occurrence and development of all kinds of benign and malignant diseases. In this article, the effects of the gut microbiota and its metabolites on the occurrence and development of endometrial cancer is reviewed, and its application in the prevention, diagnosis and treatment of endometrial cancer is explored.

Microplastics and nanoplastics (MNPs) have implicated in cardiovascular disease in preclinical studies. Our objective is to investigate the relationship between MNPs in the coronary arteries and major adverse cardiac events (MACE) in patients with myocardial infarction (MI).We conducted a prospective observational study involving patients undergoing coronary angiography for MI. Coronary blood samples were analyzed for the presence of MNPs using pyrolysis-gas chromatography-mass spectrometry. A total of 142 patients were enrolled, with 110 completing a 31.5-month follow-up. Among them, 48 (43.6 %) had detectable polystyrene, 79 (71.8 %) had polyethylene, 105 (95.4 %) had polyvinyl chloride (PVC), and 68 (61.8 %) had polyamide 66 in their coronary blood. PVC concentration was higher in patients who experienced MACE. Furthermore, PVC levels were positively associated with proinflammatory factors (IL-1β, IL-6, IL-18, and TNF-α), and associated with higher odds of MACE (OR: 1.090, 95 %CI: 1.032-1.1523, P = 0.002). Notably, for each 10-unit increase in PVC, there was a 1.374-fold increase in the risk of MACE (OR=2.374, 95 %CI: 1.366-4.128, P = 0.002). Additionally, we collected blood and thrombus samples from an additional 21 MI patients, finding that PVC levels in coronary thrombi were positively correlated with inflammatory markers and monocyte/macrophage infiltration.

Endowing channel-interconnected photoelectrode with prominent light-absorbing and analyte-trapping is pivotal but challenging for implementing high-performance photoelectrochemical sensing system. Herein, we demonstrated an effective and controllable direct ink writing (DIW) 3D printing coupled with molecular imprinting technology for consistently fabricating microlattice-shaped photoelectrochemical sensor, with multiscale well-interconnected channels created by accessible alliance of regular macrochannels originated from layer-by-layer assembly of printed filaments and abundant microchannels built by jointing molecule-recognized polyaniline (PANI), photoactive TiO₂ and conductive graphene (G) nanosheets within filaments. The unique structure merit facilitated ready spreading of incident light into the sensor interior, and meanwhile enabled rapid diffusion/infiltration of analytes onto all specificity binding sites situated inside the sensor, thereby allowing light absorbance and analyte adsorption at a high level. As a result, the 3D-printed molecularly imprinted photoelectrochemical sensor displayed impressive monitoring capability for urea, with rapid response, low detection limit (2 μM), wide linear range (10-700 μM), exceptional selectivity and working stability. This work opens up a promising route for architecting advanced photoelectrochemical devices to cater to highly sensitive and selective sensing.