Delving into the Latest Updates on Wuhan Medical College with Synapse

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OBJECTIVETo study the expression of TNF-alpha in the cholesteatoma and elucidate the role of TNF-alpha in the destruction of bone.METHODAll samples (5 microns paraffin sections) from 25 cholesteatoma cases and 10 normal cases were examined by immunohistochemical SABC method and analysed by computer image.RESULTIn 25 cholesteatoma cases, TNF-alpha expressed in the cytoplasm of the full epithelial tissue cells, subcutaneous inflammatory cells and fibroblast. In contrast, the normal cases, there were 6 cases week positive, 4 cases negative. The results of the computer image quantitative analysis system showed that the mean optical density of TNF-alpha was 0.1326 +/- 0.0022 in the cholesteatoma epithelial tissue and 0.0868 +/- 0.0014 in normal skin epithelial tissue respectively, both of which had significantly differentiation (P < 0.05).CONCLUSIONTNF-alpha may be a factor of the destruction of bone of cholesteatoma.

Zhongguo Gonggong Weisheng

Study on genotype of hantavirus strains isolated from different areas in Hubei province

Author: Qu, Hong ; Yang, Jijiang ; Liu, Hanyan ; Zhao, Min ; Ding, Xiaohua ; Liu, Dongying ; Yang, Zhanqiu ; Hou, Wei

The M genomic segment of 30 strains of Hantavirus (HV) isolated from different areas in Hubei province was analyzed to understand the genetic characteristics and the genomic function of hantavirus (HV) in Hubei province.According to Genebank software of HV, the type-specific primers were designed corresponding to the conserved sequences in the G1 region of M genomic segment of HV.Heminested RT-PCR and restriction mapping methods were applied to type and digest 30 strains of HV isolated from different areas in Hubei province.Thirty strains isolated from different areas in Hubei province were typed as 21 HTNV and 9 SEOV, resp.The restriction mappings of 21 isolates digested by Hinf I and HaeIII were consistent with those of 76/118 standard strain, but it was different from those of H-114 strain, of which digested by both HaeIII in only one segment in Wuhan and Honghu City and Hinf I in three segments in Yingcheng, Jianxia, Huangpi, and Macheng city, resp.Then all HTNV were digested by Hinc II except the above strain in Yingoheng city.In addition, 9 isolates were digested by Hinf I in two segments or EcoRI in two segments while not being digested by Hae III, which were not consistent with those of R₂₂ strain.Hubei province was an mixed epidemic areas of HFRS; the M genomic segment of SEOV was stable, but that of HTNV no stability; and distinct hantaviruses could coexist in either different or the same geog. or ecol. sores in Hubei province.

Improvement in attention following surgery treatment in pituitary adenoma patients: an evidence from ERP study

Author: Wang, Yu ; Huang, Yujing ; Song, Jian ; Xu, Guozheng ; Cao, Chenglong ; Liu, Binbin

AbstractBackground: Cognitive abilities are impaired in patients with pituitary adenoma, which are mostly treated with surgery. However, the study on neurocognitive recovery after transsphenoidal adenomectomy is lacking. The study aims to identify the electrophysiological change that relates to the attention function of pituitary adenoma patients after treatment. Methods: 27 preoperative pituitary patients and 25 follow up postoperative patients were recruited. 27 healthy controls (HCs) were matched to the patients with age, sex, and education. All the pituitary adenoma patients had successfully gone through transsphenoidal adenomectomy under microscope or endoscope. Event-related potentials were used to investigate the cognitive processes of attention for preoperative patients, postoperative patients and healthy controls. In addition, eyesight and blood hormone levels were examined. Six months after surgery, blood hormone levels, pituitary MRI and electrophysiological tests were re-examined. Results: Across three groups, all emotional stimuli could evoke P200 components. Compared with HCs or postoperative patients, the amplitudes of P200 in the preoperative patients were higher. Moreover, The amplitude of P200 decreased in postoperative patients, which was similar to that in HCs. The attention was improved after surgery, but no significant differences were detected between postoperative patients and HCs. Conclusion: The tumor mass effect and abnormal hormone may be relevant to the factors that impair the attention. Compared with that of the HCs and postoperative patients, the P200 component elicited by negative stimuli is higher in preoperative patients, which is associated with the attention impairments. Furthermore, these data indicate the improvement in attention may be attributed to the tumor resection and the amelioration of endocrine disorders. This study shows that P200 component can be used to diagnose the attention in preoperative pituitary patients, and prove the improvement of the attention in postoperative patients.

100 Deals associated with Wuhan Medical College

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100 Translational Medicine associated with Wuhan Medical College

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Pipeline

Pipeline Snapshot as of 28 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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