[Translation] A randomized, single-blind, positive-controlled study on the safety, tolerability, pharmacokinetics, and pharmacodynamics of a single dose of long-acting ropivacaine injection in healthy subjects
主要目的:考察长效罗哌卡因注射液不同剂量单次皮下给药在健康受试者中的安全性、耐受性和药代动力学;单点皮下给药的药代动力学;单点皮下最佳给药剂量。 次要目的:考察长效罗哌卡因注射液单次皮下给药在健康受试者中的药效;确定相邻注射点最佳给药间距。
[Translation] Primary objective: To investigate the safety, tolerability and pharmacokinetics of different doses of long-acting ropivacaine injection in healthy subjects after single subcutaneous administration; pharmacokinetics of single-point subcutaneous administration; optimal single-point subcutaneous administration dose. Secondary objective: To investigate the efficacy of long-acting ropivacaine injection in healthy subjects after single subcutaneous administration; to determine the optimal dosing distance between adjacent injection points.