Nectin Therapeutics Ltd.

The increasing demand for cancer monoclonal antibodies is mainly driven by the rising incidence of cancer, the growing prevalence of risk factors like smoking, radiation exposure, unhealthy lifestyles, and other contributing factors. Additionally, the surge in research and development activities by market players is expected to further fuel this demand throughout the forecast period from 2024 to 2030. LAS VEGAS, Sept. 2, 2024 /PRNewswire/ -- DelveInsight's Cancer Monoclonal Antibodies Market Insights report provides the current and forecast market analysis, individual leading cancer monoclonal antibodies companies' market shares, challenges, cancer monoclonal antibodies market drivers, barriers, trends, and key market cancer monoclonal antibodies companies in the market. Key Takeaways from the Cancer Monoclonal Antibodies Market Report As per DelveInsight estimates, North America is anticipated to dominate the global cancer monoclonal antibodies market during the forecast period. In the application segment of the cancer monoclonal antibodies market, the breast cancer category had a significant revenue share in the cancer monoclonal antibodies market in 2023. Notable cancer monoclonal antibodies companies such as GSK plc, F. Hoffmann-La Roche Ltd., Merck & Co., Inc., Novartis AG, Johnson and Johnson Services Inc., Spectrum Pharmaceuticals Inc., Eurofins Scientific, Genmab AS, Bristol Myers Squibb Company, Elli Lilly and Company, Amgen, Inc., AbbVie Inc., AstraZeneca Plc., CStone Pharmaceuticals, HiFiBiO Therapeutics, and several others, are currently operating in the cancer monoclonal antibodies market. In April 2024, CE approved the VENTANA® HER2 (4B5) Rabbit Monoclonal Primary Antibody RxDx* to identify metastatic breast cancer patients with low HER2 expression for whom ENHERTU® (trastuzumab deruxtecan) may be considered as a targeted treatment. In December 2023, CStone Pharmaceuticals announced that the National Medical Products Administration (NMPA) of China approved the supplemental biologics license application (sBLA) for sugemalimab (Cejemly®) in combination with fluorouracil and platinum-based chemotherapy as first-line treatment of unresectable locally advanced, recurrent, or metastatic esophageal squamous cell carcinoma (ESCC). Sugemalimab became the world's first anti-PD-L1 monoclonal antibody approved for the first-line ESCC indication. To read more about the latest highlights related to the cancer monoclonal antibodies market, get a snapshot of the key highlights entailed in the Global Cancer Monoclonal Antibodies Market Report Cancer Monoclonal Antibodies Overview Monoclonal antibodies (mAbs) have revolutionized cancer treatment by offering highly targeted therapies that specifically attack cancer cells while sparing healthy tissue. These antibodies are laboratory-made molecules designed to bind to specific antigens on the surface of cancer cells. By recognizing these unique markers, monoclonal antibodies can interfere with the growth and spread of cancer in several ways. For example, they can block signals that stimulate cancer cell proliferation, mark cancer cells for destruction by the immune system, or deliver toxic substances directly to the cancer cells. This specificity reduces the side effects typically associated with conventional chemotherapy and radiation, making mAbs an essential component of modern oncology. There are several types of monoclonal antibodies used in cancer treatment, including naked mAbs, which work by themselves, and conjugated mAbs, which are linked to drugs or radioactive particles. Some well-known examples include Rituximab, used in the treatment of certain types of lymphoma, and Trastuzumab, which targets HER2-positive breast cancer. These therapies have shown significant success in improving survival rates and quality of life for many patients. However, challenges remain, such as the development of resistance by cancer cells and the high cost of production. Ongoing research aims to overcome these hurdles by developing more effective and affordable mAbs, as well as combining them with other treatments to enhance their efficacy. Cancer Monoclonal Antibodies Market Insights North America held the largest share of the cancer monoclonal antibodies market in 2023, driven by several factors. The region's leading position is attributed to the rising incidence of cancers, greater exposure to carcinogens such as smoking, radiation, and viruses, and recent regulatory approvals that favor the growth of the cancer monoclonal antibodies market in North America. Furthermore, the increasing number of regulatory approvals for these antibodies is expected to further stimulate market growth. For instance, in October 2022, the FDA approved the combination of durvalumab (IMFINZI), a human monoclonal antibody, with the experimental drug tremelimumab for treating unresectable hepatocellular carcinoma. The large patient population in North America is likely to drive demand for cancer monoclonal antibodies, leading to market expansion in the coming years. Therefore, the combined influence of these factors is expected to contribute significantly to the growth of the cancer monoclonal antibodies Market in North America from 2024 to 2030. To know more about why North America is leading the market growth in the cancer monoclonal antibodies market, get a snapshot of the Cancer Monoclonal Antibodies Market Outlook Cancer Monoclonal Antibodies Market Dynamics The global market for cancer monoclonal antibodies has experienced significant growth over the past decade, driven by the increasing incidence of cancer, advancements in biotechnology, and the rising demand for targeted therapies. Monoclonal antibodies, which are designed to specifically target cancer cells while sparing healthy tissue, have become a cornerstone in the treatment of various cancers. Their specificity and reduced side effects compared to traditional chemotherapy have made them an attractive option for both patients and healthcare providers. One of the key dynamics shaping the cancer monoclonal antibodies market is the ongoing innovation in antibody engineering. Techniques such as antibody-drug conjugates, bispecific antibodies, and immune checkpoint inhibitors have expanded the therapeutic potential of mAbs, leading to the development of more effective and versatile cancer treatments. These innovations have not only enhanced the efficacy of existing therapies but have also opened up new avenues for addressing previously untreatable or resistant forms of cancer. The competitive landscape of the market is also influenced by the expiration of patents on several blockbuster mAbs, paving the way for biosimilars to enter the market. Biosimilars, which are essentially generic versions of biologic drugs, offer similar efficacy at a lower cost, making cancer treatment more accessible. However, the introduction of biosimilars has also intensified competition among pharmaceutical companies, driving the need for continuous innovation and the development of next-generation therapies to maintain market share. Regulatory and reimbursement challenges also play a crucial role in the market dynamics. The stringent regulatory requirements for the approval of mAbs, coupled with the high costs associated with their development and manufacturing, can pose barriers to market entry. Additionally, securing favorable reimbursement from healthcare systems is critical for the widespread adoption of these therapies. As healthcare budgets become increasingly strained, especially in the wake of the COVID-19 pandemic, the cost-effectiveness of mAbs will likely be a focal point in discussions between pharmaceutical companies, regulators, and payers. In conclusion, the cancer monoclonal antibodies market is poised for continued growth, driven by technological advancements, the entry of biosimilars, and the rising demand for personalized cancer therapies. However, the market will need to navigate challenges related to regulation, competition, and cost-effectiveness to sustain its momentum. As research and development in the field of immuno-oncology continue to advance, the landscape of cancer treatment is likely to evolve, offering new hope for patients and further solidifying the role of monoclonal antibodies in cancer care. Get a sneak peek at the cancer monoclonal antibodies market dynamics @ Cancer Monoclonal Antibodies Market Dynamics Analysis Cancer Monoclonal Antibodies Market Assessment Cancer Monoclonal Antibodies Market Segmentation Cancer Monoclonal Antibodies Market Segmentation By Type: Humanized Antibodies, Chimeric Antibodies, Murine Antibodies Cancer Monoclonal Antibodies Market Segmentation By Application: Blood Cancer, Breast Cancer, Liver Cancer, Colorectal Cancer, and Others Cancer Monoclonal Antibodies Market Segmentation By End Users: Hospitals, Research Institutions & Laboratories, and Others Cancer Monoclonal Antibodies Market Segmentation By Geography: North America, Europe, Asia-Pacific, and Rest of World Porter's Five Forces Analysis, Product Profiles, Case Studies, KOL's Views, Analyst's View Which MedTech key players in the cancer monoclonal antibodies market are set to emerge as the trendsetter explore @ Cancer Monoclonal Antibodies Companies Table of Contents Interested in knowing the cancer monoclonal antibodies market by 2030? Click to get a snapshot of the Cancer Monoclonal Antibodies Market Trends Related Reports Monoclonal Antibodies Competitive Landscape Monoclonal Antibodies Competitive Landscape – 2024 report provides comprehensive insights about the pipeline landscape, pipeline drug profiles, including clinical and non-clinical stage products, and the key monoclonal antibodies companies, including Novartis , Novartis, Gmax Biopharm, Omeros Corporation, Merck Sharp & Dohme, Disc Medicine, Eledon Pharmaceuticals, Alexion AstraZeneca Rare Disease, Chinook Therapeutics, Omeros Corporation, Novo Nordisk, Merck KGaA, Bristol-Myers Squibb, Jacobio Pharmaceuticals, Nectin Therapeutics Ltd, Y-mAbs Therapeutics, OncoResponse, Inc., Fate Therapeutics, Pelican Therapeutics, Inc., Heat Biologics, Oncternal Therapeutics, Phanes Therapeutics, Pharmacyclics LLC, Immunitas Therapeutics, Hummingbird Bioscience, Inc., Sanofi, Takeda, Agenus Inc., Aulos Bioscience, Inc., ChemomAb Ltd, Celldex Therapeutics, Celgene, Janssen Research & Development, LLC, Adaptive Biotechnologies, BeiGene, Vaccinex Inc., Jasper Therapeutics, Inc., Shanghai Junshi Bioscience Co., Ltd., TopAlliance Biosciences, Inc., among others. Cancer Therapy Market Cancer Therapy Market Insight, Competitive Landscape, and Market Forecast – 2030 report delivers an in-depth understanding of market trends, market drivers, market barriers, and key cancer therapy companies, including GlaxoSmithKline, Eli Lilly & Company, F. Hoffmann-La Roche Ltd, AbbVie Inc., Amgen Inc, Sanofi, Merck & Co., Inc, Novartis AG, Pfizer Inc, AstraZeneca, Bristol Myers Squibb., Gilead Sciences, Inc., Janssen Global Services, LLC, Elekta AB, Varian Medical Systems, Inc., Accuray Incorporated, Pyrexar Medical, Eckert & Ziegler, IBA, Panacea Medical Technologies Pvt. Ltd., among others. Oncology Drugs Market Oncology Drugs Market Insight, Competitive Landscape, and Market Forecast – 2030 report delivers an in-depth understanding of market trends, market drivers, market barriers, and key oncology drugs companies, including GlaxoSmithKline, Eli Lilly & Company, F. Hoffmann-La Roche Ltd, AbbVie Inc., Amgen Inc, Sanofi, Merck & Co., Inc, Novartis AG, Pfizer Inc, AstraZeneca, Bristol Myers Squibb., Gilead Sciences, Inc., Janssen Global Services, LLC, BAYER AG., Celldex Therapeutics Inc., Alaunos Therapeutics, Inc., Astellas Pharma Inc., Genentech, Inc., Sandoz International GmbH, BeiGene, among others. Non-small Cell Lung Cancer Market Non-small Cell Lung Cancer Market Insights, Epidemiology, and Market Forecast – 2032 report deliver an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key NSCLC companies, including EMD Serono, Merck, Cellular Biomedicine Group, Inc., Celgene, CellSight Technologies, Inc., BeyondSpring Pharmaceuticals Inc., J Ints Bio, Forward Pharmaceuticals Co., Ltd., AstraZeneca, Bristol-Myers Squibb, Teligene US, Rain Oncology Inc, ReHeva Biosciences, Inc., Amgen, Novartis, RedCloud Bio, Parexel, Vitrac Therapeutics, LLC, Mythic Therapeutics, Instil Bio, Mirati Therapeutics Inc., Daiichi Sankyo, Inc., AstraZeneca, Precision Biologics, Inc, Promontory Therapeutics Inc., Palobiofarma SL, Regeneron Pharmaceuticals, Revolution Medicines, Inc., Cullinan Oncology, LLC, Iovance Biotherapeutics, Inc., Innate Pharma, among others. About DelveInsight DelveInsight is a leading Business Consultant, and Market Research firm focused exclusively on life sciences. It supports pharma companies by providing comprehensive end-to-end solutions to improve their performance. Contact Us Shruti Thakur [email protected] +14699457679 Logo: SOURCE DelveInsight Business Research, LLP

BOTHELL, Wash.--( BUSINESS WIRE )-- Immunome, Inc. (Nasdaq: IMNM), a biotechnology company focused on the development of first-in-class and best-in-class targeted oncology therapies, today announced financial results for the second quarter ended June 30, 2024, and provided a business update. “Immunome is focused on establishing and developing a broad pipeline of differentiated oncology therapies. We continue to advance work required to prepare AL102 for regulatory submissions, and we are moving towards submitting INDs for IM-1021 and IM-3050,” said Clay B. Siegall, Ph.D., President and Chief Executive Officer. “These programs are supported by an expanding team of drug developers, including leaders who previously contributed to the successful development and commercialization of ADCs and small molecules.” Dr. Siegall continued, “In addition to our clinical pipeline, we have identified multiple promising ADC targets, all of which offer first-in-class potential. We believe that cost-effective business development efforts combined with focused research can accelerate the expansion of our pipeline and that rigorous science provides the foundation for transformative cancer therapies.” Pipeline Highlights Full enrollment for the Phase 3 RINGSIDE Part B study of AL102 for the treatment of desmoid tumors was completed in February 2024, and Immunome continues to expect to report topline data for RINGSIDE Part B in the second half of 2025. In parallel, Immunome is performing additional manufacturing and pharmacology work required to support a new drug application filing for AL102. Immunome also anticipates submitting INDs for IM-1021 and IM-3050 in the first quarter of 2025, as previously disclosed. These programs are complemented by robust discovery efforts centered on next-generation ADCs and active business development activity, including recent transactions with Atreca, Nectin Therapeutics, Bluefin Biomedicine, and OncoResponse intended to expand Immunome’s ADC toolbox. Second Quarter 2024 Financial Results As of June 30, 2024, cash, cash equivalents and marketable securities totaled $278.4 million. Immunome’s current cash runway is expected to extend into 2026. Research and development expenses for the quarter ended June 30, 2024 were $29.1 million, including stock-based compensation costs of $1.0 million. In-process research and development expenses for the quarter ended June 30 th , 2024 were $6.3 million. These expenses were related to Immunome’s business development activity. General and administrative expenses for the quarter ended June 30, 2024 were $7.0 million, including stock-based compensation expense of $2.2 million. Immunome reported a net loss of $36.1 million for the quarter ended June 30, 2024. About Immunome, Inc. Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted therapies designed to improve outcomes for cancer patients. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development and commercialization of cutting-edge targeted cancer therapies, including antibody-drug conjugates (ADCs). In addition to a portfolio of discovery-stage ADCs, our pipeline includes AL102, a gamma secretase inhibitor currently in a Phase 3 trial for treatment of desmoid tumors, as well as IM-1021, a ROR1 ADC, and IM-3050, a FAP-targeted radioligand, both of which are the subject of INDs expected to be submitted in the first quarter of 2025. For more information, visit www.immunome.com . Cautionary Statement Regarding Forward-Looking Statements Statements in this press release that are not purely historical in nature are “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. We use words such as “believe,” “expected,” “look forward” and similar expressions to identify these forward-looking statements. These forward-looking statements include, but are not limited to, Immunome’s expected timing for filing an IND for IM-1021 and IM-3050; Immunome’s expected timing for providing topline data for the Phase 3 RINGSIDE Part B trial; Immunome’s expected cash runway; the potential of Immunome’s ADC targets to provide first-in-class potential; and other statements regarding management’s intentions, plans, beliefs, expectations or forecasts for the future. These forward-looking statements are based on Immunome’s current expectations and involve assumptions that may never materialize or may prove to be incorrect; consequently, actual results may differ materially from those expressed or implied in the statements due to a number of factors, including, but not limited to, the risk that Immunome will not be able to realize the benefits of its strategic transactions; the risk that regulatory approvals for Immunome’s programs and product candidates are not obtained, are delayed or are subject to unanticipated conditions; the risk that pre-clinical data may not be predictive of clinical data; the risk that Immunome’s product candidates and development candidates fail to achieve their intended endpoints; the reliance on Immunome’s management; the prior experience and successes of Immunome’s management team not being indicative of any future success; uncertainties related to Immunome’s capital requirements and Immunome’s expected cash runway; Immunome’s ability to grow and successfully execute on its business plan, including the development and commercialization of its pipeline and integration of newly acquired assets; and other risks and uncertainties indicated from time to time described in Immunome’s Quarterly Report on Form 10-Q for the quarter ended March 31, 2024, filed with the SEC on May 14, 2024, in Immunome’s Quarterly Report on Form 10-Q for the quarter ended June 30, 2024, being filed with the SEC today, and in Immunome’s other filings with the SEC. Except as required by law, Immunome assumes no obligation and does not intend to update any forward-looking statements included in this press release. Immunome, Inc. Consolidated Balance Sheets (Unaudited; In thousands, except share and per share amounts) June 30, 2024 December 31, 2023 Assets Current assets: Cash and cash equivalents $ 165,332 $ 98,679 Marketable securities 113,021 39,463 Prepaid expenses and other current assets 5,931 6,561 Total current assets 284,284 144,703 Property and equipment, net 6,096 2,073 Operating right-of-use assets 2,523 1,564 Restricted cash 100 100 Other long-term assets 3,212 100 Total assets $ 296,215 $ 148,540 Liabilities and stockholders’ equity Current liabilities: Accounts payable $ 7,047 $ 3,311 Accrued expenses and other current liabilities 20,264 8,025 Deferred revenue, current 12,589 10,493 Total current liabilities 39,900 21,829 Deferred revenue, non-current — 5,489 Operating lease liabilities, net of current portion 2,477 1,340 Total liabilities 42,377 28,658 Stockholders’ equity: Preferred stock — — Common stock 6 4 Additional paid-in capital 642,251 342,663 Accumulated other comprehensive income 2 22 Accumulated deficit (388,421 ) (222,807 ) Total stockholders’ equity 253,838 119,882 Total liabilities and stockholders’ equity $ 296,215 $ 148,540 Immunome, Inc. Consolidated Statements of Operations (Unaudited; In thousands, except share and per share amounts) Three Months Ended June 30, Six Months Ended June 30, 2024 2023 2024 2023 Collaboration revenue $ 2,364 $ 4,263 $ 3,393 $ 6,627 Operating expenses: In-process research and development 6,312 — 118,266 — Research and development 29,083 5,716 44,452 9,629 General and administrative 6,978 4,320 12,983 7,242 Total operating expenses 42,373 10,036 175,701 16,871 Loss from operations (40,009 ) (5,773 ) (172,308 ) (10,244 ) Interest income 3,887 216 6,694 417 Net loss $ (36,122 ) $ (5,557 ) $ (165,614 ) $ (9,827 ) Net loss per share, basic and diluted $ (0.60 ) $ (0.46 ) $ (2.97 ) $ (0.81 ) Weighted-average shares outstanding, basic and diluted 59,936,703 12,197,801 55,740,543 12,190,182 Comprehensive loss Net loss $ (36,122 ) $ (5,557 ) $ (165,614 ) $ (9,827 ) Unrealized loss on marketable securities (2 ) — (20 ) — Comprehensive loss $ (36,124 ) $ (5,557 ) $ (165,634 ) $ (9,827 ) (1) Amounts include non-cash stock based compensation as follows (in thousands): Three Months Ended June 30, Six Months Ended June 30, 2024 2023 2024 2023 Research and development $ 1,041 $ 427 $ 1,424 $ 857 General and administrative 2,186 606 3,962 1,400 Total share-based compensation expense $ 3,227 $ 1,033 $ 5,386 $ 2,257

– Exclusive worldwide license agreement for antibodies against undisclosed target JERUSALEM, July 25, 2024 /PRNewswire/ -- Nectin Therapeutics, Ltd., a biotechnology company developing novel immunotherapies and antibody drug conjugates (ADC) to address tumor resistance, today announced a global, exclusive license agreement with Immunome Inc. (Nasdaq: IMNM), a biotechnology company focused on developing first-in-class and best-in-class targeted cancer therapies. Under the terms of the license, Immunome received exclusive rights to a panel of antibodies targeting an undisclosed target. "This agreement allows Nectin to realize value while further pursuing and enabling the focus on our first-in-class anti-PVR program (NTX1088) through its ongoing clinical study in tumor types with high unmet need as well as advance our novel ADCs into clinical development. Immunome's leadership team's track record of developing and commercializing novel ADC therapies makes it an ideal partner to advance these promising assets," said Fabian Tenenbaum, Chief Executive Officer of Nectin Therapeutics. "Immunome believes the next generation of transformative antibody drug conjugates will address novel targets by pairing high-quality antibodies with innovative linker-payload technology," said Clay Siegall, PhD, President and Chief Executive Officer of Immunome. "We appreciate the work Nectin has done on these antibodies and look forward to advancing them further." Under the terms of the agreement, Nectin granted Immunome an exclusive, worldwide, all-fields license to monoclonal antibodies that are directed to a single undisclosed target. Immunome will be responsible for the research, development, manufacturing and commercialization of products incorporating these antibodies. Nectin will receive an upfront payment and will be eligible for milestones and royalties. About Nectin Therapeutics, LTD. Nectin Therapeutics is a clinical stage biotechnology company devoted to transforming the lives of cancer patients by leveraging unique insights into Nectin pathways to develop the next generation of immune oncology (IO) therapies and antibody drug conjugates (ADCs). The company's differentiated therapies have the potential to set new standards for efficacy and patient response rates across various difficult-to-treat cancers. Nectin's technology addresses major escape mechanisms of current IO therapies through a diverse pipeline of novel monoclonal antibodies and antibody drug conjugates (ADCs). It has a world-class scientific and management team with deep experience in oncology drug development and successful track records in building biotechnology companies and developing innovative therapies. Nectin Therapeutics is a venture-backed, privately held company, funded by aMoon Fund, Peregrine Ventures, IBF, Integra Holdings, the Myeloma Investment Fund (MIF), GIBF and the Cancer Focus Fund. Nectin Contact: Fabian Tenenbaum Chief Executive Officer [email protected] +1 201 218-1774 SOURCE Nectin Therapeutics