Bupropion hydrochloride is an antidepressant.M-chlorobenzoyl chloride takes for raw material in this article.After through acrylate, Grignard reaction, bromination, N-alkylation, the bupropion hydrochloride was obtained.The structures of the products were determined by elemental anal., UV, IR, 1H-NMR, 13C-NMR and MS, the total yield of bupropion hydrochloride was 50.8% based on m-chlorobenzoyl chloride.The result shows that the method is convenient and the total yield is higher.