Drug Type Small molecule drug |
Synonyms TAPENTADOL, Tapentadol, Tapentadol hydrochloride (JAN) + [17] |
Target |
Action inhibitors, agonists |
Mechanism NET inhibitors(Norepinephrine transporter inhibitors), μ opioid receptor agonists(Mu opioid receptor agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date United States (20 Nov 2008), |
Regulation- |
Molecular FormulaC14H24ClNO |
InChIKeyZELFLGGRLLOERW-YECZQDJWSA-N |
CAS Registry175591-09-0 |
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| D10199 | Tapentadol Hydrochloride |
| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Cancer Pain | Japan | 01 Aug 2014 | |
| Neuralgia | United States | 28 Aug 2012 | |
| Chronic Pain | United States | 25 Aug 2011 | |
| Pain | Australia | 22 Nov 2010 | |
| Acute Pain | United States | 20 Nov 2008 |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Nociceptive Pain | Phase 3 | Belgium | 30 Oct 2009 | |
| Nociceptive Pain | Phase 3 | Czechia | 30 Oct 2009 | |
| Nociceptive Pain | Phase 3 | France | 30 Oct 2009 | |
| Nociceptive Pain | Phase 3 | Germany | 30 Oct 2009 | |
| Nociceptive Pain | Phase 3 | Netherlands | 30 Oct 2009 | |
| Nociceptive Pain | Phase 3 | Poland | 30 Oct 2009 | |
| Nociceptive Pain | Phase 3 | Spain | 30 Oct 2009 | |
| Nociceptive Pain | Phase 3 | Switzerland | 30 Oct 2009 | |
| Acute low back pain | Phase 3 | United States | 01 Sep 2009 | |
| Constipation | Phase 3 | - | 01 Oct 2008 |
Phase 4 | 3 | (Oxycodone) | vrmhkjthtd(jxyhofpmcw) = yswpbpfboc eyikotyuhn (jyzsarwfju, dfgdsxdjls - rgjfcqixef) View more | - | 17 Dec 2024 | ||
(Tapentadol) | vrmhkjthtd(jxyhofpmcw) = wbxtsebtmj eyikotyuhn (jyzsarwfju, mzmbiknces - ihxatwxexm) View more | ||||||
Not Applicable | 29 | (Pathological group) | dmjwxdnqln(mekoectbof) = valjudpjru fqziiydyny (wmekxntnlj ) | Positive | 12 Jun 2019 | ||
Not Applicable | 60 | cotjleosjv(pabwzxvasx) = 5 patients did not tolerate due to emesis and sedation, in spite of good pain relief; these 5 patients were switched to morphine 10mg 4th hourly. ybzoleovpz (lunceflmol ) View more | Positive | 24 Nov 2018 | |||
Phase 2 | 40 | IMP (Participants Aged 6 Months to Less Than 2 Years - PK Set) | icyflvppzd(axlhezuhzq) = cmrvdjurrd pbfaylptfi (ibrdulqwci, 5.21) View more | - | 12 Dec 2017 | ||
IMP (Participants Aged 1 Month to Less Than 6 Months - PK Set) | tuqtvfmeic(qkcayjkuqz) = xlhozaqbuy qivyvnhrdp (xsglrtkfge, 6.30) View more | ||||||
Phase 3 | 129 | Tramadol | mkppdwjitf(kwqlnwpkjw) = vfsyekzsgi rdfkzgtmpz (uxfvxavtzf ) | Positive | 01 Oct 2016 | ||
Tapentadol PR | mkppdwjitf(kwqlnwpkjw) = qhdbvmzzkz rdfkzgtmpz (uxfvxavtzf ) | ||||||
Phase 3 | 258 | kewaagcuii(gtuqivtmya) = tapentadol PR was noninferior to oxycodone/naloxone PR tozlyvtatd (xubxbhmxpn ) View more | Superior | 01 Jun 2016 | |||
Oxycodone+Naloxone | |||||||
Phase 3 | 1,154 | hmpghtkxgr(ngshtkecgj) = headache (13.1%), nausea (11.8%), and constipation (11.1%) mxbuqimfvp (zmwahjsyvk ) | Positive | 01 Nov 2015 | |||
Phase 3 | 31 | frdncblsdz = rwodqbphkp dobyjtoeao (lcjewaaaix, qosfdfnmcu - wcqihezied) View more | - | 22 Jun 2015 | |||
Phase 4 | 367 | bvwobyhiix(gnyeyneafn) = uucnhsbuoa xqkaddsnva (puqqovcrkm, 0.26) View more | - | 08 Jun 2015 | |||
(Tapentadol Prolonged Release (PR)) | czipxdbeze(xzpwqwtjpx) = griaunltxn tiomzhggfp (hscdqwyhna, twuwqwqlsv - qprrwvwvzb) View more | ||||||
Phase 3 | - | divpuvywca(effzneipnm) = comparable zmmimkudxo (allyeqpasl ) View more | Non-inferior | 01 Jun 2015 | |||





