A randomized controlled study of risk factors associated with residual numbness after lumbar disc herniation and the therapeutic effect of umbilical acupuncture combined with warm acupuncture

Start Date01 Jan 2025

Sponsor / Collaborator

The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine

NCT06649422 / Not yet recruitingNot ApplicableIIT

Clinical Study on the Efficacy and Safety of Reduced-Dose Chemotherapy Followed by 14 Days of Blinatumomab in Adult Patients with Newly Diagnosed Ph-Negative B-ALL: a Prospective, Multicenter, Observational Study.

This is a prospective, multicenter, observational study aimed at exploring the efficacy and safety of reduced-dose chemotherapy followed by frontline therapy with blinatumomab in patients aged 15-65 with newly diagnosed Ph-negative B-ALL.

Start Date01 Nov 2024

Sponsor / Collaborator

Shandong University

[+12]

ITMCTR2024000429 / Suspended

A study of the seven-seven theory based on the expression of biological clock genes in granulosa cells of IVF-ET patients of different age groups

Start Date01 Oct 2024

Sponsor / Collaborator

The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine

100 Clinical Results associated with The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine

0 Patents (Medical) associated with The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine

Literatures (Medical) associated with The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine

01 Oct 2024·Biomedicine & Pharmacotherapy

Hirudin delays the progression of diabetic kidney disease by inhibiting glomerular endothelial cell migration and abnormal angiogenesis

Article

Author: Zhang, Fengyi ; Yu, Xiaoying ; Zhang, Jiayi ; Zhang, Yufeng ; Wang, Wenbo ; Tong, Xiaolin ; Li, Yujie ; Liu, Xuemei ; Zhao, Yifeng ; Su, Jie ; Zhang, Lili ; Zhao, Linhua

BACKGROUNDIn the early stages of diabetic kidney disease (DKD), the pathogenesis involves abnormal angiogenesis in the glomerulus. Hirudin, as a natural specific inhibitor of thrombin, has been shown in previous studies to inhibit the migration of various tumor endothelial cells and abnormal angiogenesis. However, its role in DKD remains unclear.METHODSThe effects of hirudin in DKD were studied using spontaneous type 2 diabetic db/db mice (which develop kidney damage at 8 weeks). Network pharmacology was utilized to identify relevant targets. An in vitro high glucose model was established using mouse glomerular endothelial cells (MGECs) to investigate the effects of hirudin on the migration and angiogenic capacity of MGECs.RESULTSHirudin can ameliorate kidney damage in db/db mice. Network pharmacology suggests its potential association with the VEGFA/VEGFR2 pathway. Western blot and immunohistochemistry demonstrated elevated protein expression levels of VEGFA, VEGFR2, AQP1, and CD31 in db/db mice, while hirudin treatment reduced their expression. In the MGECs high glucose model, hirudin may reverse the enhanced migration and angiogenic capacity of MGECs in a high glucose environment by altering the expression of VEGFA, VEGFR2, AQP1, and CD31. Moreover, the drug effect gradually increases with higher concentrations of hirudin.CONCLUSIONSThis study suggests that hirudin can improve early-stage diabetic kidney disease kidney damage by inhibiting the migration and angiogenesis of glomerular endothelial cells, thereby further expanding the application scope of hirudin. Additionally, the study found increased expression of AQP1 in DKD, providing a new perspective for further research on the potential pathogenesis of DKD.

28 Mar 2024·Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

Research progress in the relationship between gut microbiota metabolite trimethylamine N-oxide and ischemic stroke.

Review

Author: Fu, Yu ; Li, Li ; Hou, Xiaoqian ; Feng, Huiyue ; Feng, Ziyun

Ischemic stroke (IS) is a severe cerebrovascular disease that seriously endangers human health. Gut microbiota plays a key role as an intermediate mediator in bidirectional regulation between the brain and the intestine. In recent years, trimethylamine N-oxide (TMAO) as a gut microbiota metabolite has received widespread attention in cardiovascular diseases. Elevated levels of TMAO may increase the risk of IS by affecting IS risk factors such as atherosclerosis, atrial fibrillation, hypertension, and type 2 diabetes. TMAO exacerbates neurological damage in IS patients, increases the risk of IS recurrence, and is an independent predictor of post-stroke cognitive impairment (PSCI) in patients. Current research suggests that the mechanisms of TMAO action include endothelial dysfunction, promoting of foam cell formation, influence on cholesterol metabolism, and enhancement of platelet reactivity. Lowering plasma TMAO levels through the rational use of traditional Chinese medicine, dietary management, vitamins, and probiotics can prevent and treat IS.

28 Mar 2024·Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

Correlation between obesity and early vascular aging in middle-aged and young adult health check-up populations.

Article

Author: Cui, Man ; Li, Ying ; Miao, Rujia ; Zhou, Hui ; Li, Yapei ; Wang, Jiangang ; Zhao, Linlin

OBJECTIVESThe obesity rate among middle-aged and young adults in China is increasing annually, and the incidence of cardiovascular diseases is becoming more prevalent in younger populations. However, it has not yet been reported whether obesity is associated with early vascular aging (EVA). This study aims to explore the correlation between obesity and EVA in middle-aged and young adult health check-up populations, providing a reference for the prevention of cardiovascular diseases.METHODSA total of 15 464 middle-aged and young adults aged 18-59 who completed brachial-ankle pulse wave velocity (baPWV) test in the Third Xiangya Hospital of Central South University from January to December 2020 were included. Among them, 1 965 individuals with normal blood pressure and no cardiovascular risk factors were selected as the healthy population. The baPWV thresholds for determining EVA in each age group for males and females were calculated based on the baPWV values of the healthy population. The number and percentage of individuals meeting the EVA criteria in the middle-aged and young adult health check-up populations were statistically analyzed by age and gender. The differences in obesity indicators [visceral adiposity index (VAI), body mass index (BMI), waist circumference (WC)] between the EVA and non-EVA groups for males and females were compared. Using EVA as the dependent variable, VAI, BMI, and WC were included as independent variables in a Logistic model to analyze the correlation between each obesity indicator and EVA before and after adjusting for other influencing factors. Furthermore, the correlation between each obesity indicator and EVA in each age group was analyzed.RESULTSIn the health check-up populations, the detection rate of EVA in different age groups was 1.65%-10.92% for males, and 1.16%-10.50% for females, the detection rate of EVA increased with age in both males and females. Except for the 40-<50 age group, the EVA detection rate was higher in males than in females in all other age groups. Regardless of gender, obesity indicators VAI, BMI, and WC were significantly higher in the EVA group than in the non-EVA group (all P<0.01). Before and after adjusting for other influencing factors, VAI and WC were both correlated with EVA (both P<0.05). BMI was a risk factor for EVA before adjusting for other influencing factors (P<0.01), but after adjustment, the correlation between BMI and EVA was not statistically significant (P=0.05). After adjusting for other influencing factors, the correlation between VAI and EVA was statistically significant in the 18-<40 and 50-<60 age groups (both P<0.05), while the correlation between BMI and WC with EVA was not statistically significant (both P>0.05). In the 40-<50 age group, the correlation between VAI and BMI with EVA was not statistically significant (both P>0.05), but the correlation between WC and EVA was statistically significant (P<0.01).CONCLUSIONSVAI is closely related to the occurrence of EVA in middle-aged and young adults aged 18-<40 and 50-<60 years, while WC is closely related to the occurrence of EVA in those aged 40-<50 years.

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