[Translation] A randomized, double-blind, placebo-controlled, multicenter, phase II clinical study of AC591 granules in preventing peripheral neuropathy induced by oxaliplatin chemotherapy

主要目的：评价AC591颗粒预防接受辅助治疗结直肠癌患者因奥沙利铂化疗引起的外周神经病变的有效性。次要目的： 1) 评价AC591颗粒对使用奥沙利铂化疗的结直肠癌患者的生活质量影响； 2) 评价AC591颗粒对使用奥沙利铂化疗的结直肠癌患者的安全性影响。

[Translation]

Primary objective: To evaluate the effectiveness of AC591 granules in preventing peripheral neuropathy caused by oxaliplatin chemotherapy in patients with colorectal cancer receiving adjuvant therapy. Secondary objectives: 1) To evaluate the effect of AC591 granules on the quality of life of patients with colorectal cancer receiving oxaliplatin chemotherapy; 2) To evaluate the safety of AC591 granules in patients with colorectal cancer receiving oxaliplatin chemotherapy.

Start Date08 Jan 2025

Sponsor / Collaborator

Jiangsu Province Hospital of Traditional Chinese Medicine

[+1]

ITMCTR2024000856

/ SuspendedNot ApplicableIIT

Research on the Integrated Multi-Stage Multi-Center and Hospital-Community Collaborative Traditional Chinese and Western Medicine Treatment Program for Diabetic Nephropathy within Medical Consortiums

Start Date01 Jan 2025

Sponsor / Collaborator

Jiangsu Province Hospital of Traditional Chinese Medicine

NCT06762223

/ Not yet recruitingPhase 4IIT

Intervention of Henagliflozin on Liver Fibrosis in Patients with Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) and Type 2 Diabetes Mellitus (T2DM)

The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) is increasing due to changes in economic conditions and lifestyle, and it is anticipated to become a significant liver disease burden in the future. This is particularly true for patients with MASLD who also have type 2 diabetes mellitus (T2DM), as the rate of comorbidity between these conditions has risen in recent years due to their shared mechanisms, necessitating careful management of both. Liver fibrosis is a critical concern, as poor blood glucose control can worsen liver fibrosis, which in turn complicates blood sugar management. Therefore, addressing liver fibrosis in patients with MASLD and T2DM is urgent, yet there are currently no targeted therapies to reverse its progression. SGLT2 inhibitors, have shown promise in potentially reversing liver fibrosis, but existing research is limited and has not adequately focused on liver fibrosis improvement, highlighting the need for more robust evidence-based studies.

Start Date31 Dec 2024

Sponsor / Collaborator

Jiangsu Province Hospital of Traditional Chinese Medicine

[+1]

100 Clinical Results associated with Jiangsu Province Hospital of Traditional Chinese Medicine

0 Patents (Medical) associated with Jiangsu Province Hospital of Traditional Chinese Medicine

374

Literatures (Medical) associated with Jiangsu Province Hospital of Traditional Chinese Medicine

01 Jul 2025·Journal of Orthopaedics

Comparison of the effects between arthroscopic transtibial pullout technique and all-inside repair in the treatment of medial meniscus posterior root tears

Article

Author: Wei, Chengjian ; Qu, Yuxing ; Min, Wen ; Shen, Pengfei ; Li, Jun ; Xie, Zikang ; Zou, Tao

Background:

Medial meniscus posterior root tears (MMPRTs) significantly contribute to knee dysfunction, leading to abnormal biomechanics and accelerated cartilage degeneration. Arthroscopic transtibial pullout and all-inside repair are two commonly used techniques for treating MMPRTs, each with unique advantages and limitations.

Objective:

To compare the clinical and functional outcomes of the transtibial pullout and all-inside repair techniques in the treatment of MMPRTs, with a focus on postoperative recovery, knee function, and complications.

Methods:

40 patients with MMPRTs were randomized to undergo either the transtibial pullout or all-inside repair technique. Clinical outcomes were evaluated using the International Knee Documentation Committee (IKDC) score, Tegner activity scale, Lysholm score, and active range of motion (AROM) of knee flexion, both before and after surgery. Data on operative time, time to ambulation, hospital stay duration, and complications were also collected.

Results:

Both surgical groups showed significant improvements in clinical outcomes postoperatively (p < 0.001). The transtibial group exhibited greater functional recovery, with IKDC, Tegner, and Lysholm scores improving by approximately 60 %, 110 %, and 68 %, respectively, compared to the all-inside group. However, complications were more frequent in the transtibial group, including three cases of wound healing issues and one infection, while the all-inside group had one case of deep vein thrombosis. No re-tears were observed in either group during follow-up.

Conclusion:

Both the transtibial pullout and all-inside repair techniques effectively restore knee function in patients with MMPRTs. While the transtibial pullout provides better functional outcomes, it is associated with a higher complication rate. The choice of surgical approach should consider patient-specific factors, including tear characteristics and overall health, to optimize results.

01 Jan 2025·JOURNAL OF ETHNOPHARMACOLOGY

Mechanistic study of the regulation of mitochondrial function by the GPNMB/Nrf2/NF-κB signaling pathway mediated by Quzhi Tang to alleviate chondrocyte senescence

Article

Author: Xu, Bo ; Zhu, Zaishi ; Wang, Peimin ; Jie, Lishi ; Li, Yuwei ; Zhang, Chaofeng ; Huang, Zeling ; Liu, Yujiang ; Shi, Xiaoqing

ETHNOPHARMACOLOGICAL RELEVANCE:

Quzhi Tang (QZT) is a compound formula consisting of six traditional Chinese medicinal herbs. It has achieved good clinical results in the treatment of knee osteoarthritis (KOA), and the potential drug mechanisms involved are worth exploring in depth.

MATERIALS AND METHODS:

Using single-cell transcriptome analysis, this study identified the key target of senescence, GPNMB. Then, it investigated the mechanism by which QZT regulates the GPNMB/Nrf2/NF-κB signaling pathway to repair mitochondrial damage and ameliorate the process of chondrocyte senescence.

RESULTS:

We collected cartilage tissues from mice and identified GPNMB as a key target of chondrocyte senescence by combining transcriptomics, histopathology, molecular biology, and immunology methods. The effects of QZT on the level of chondrocyte senescence in mice and its ameliorative effect on KOA were studied. In in vivo experiments, we explored the mechanism of GPNMB in the development of senescence in detail and revealed that, after siRNA-GPNMB interference, chondrocytes exhibited reduced impairment of mitochondrial function and senescence under equal amounts of stimuli, increasing Nrf2 expression and reducing NF-κB expression. In addition, the level of oxidative stress increased in chondrocytes overexpressing GPNMB after lentiviral infiltration, aggravating the impairment of mitochondrial function. After treatment with QZT, chondrocytes overexpressing GPNMB were able to increase Nrf2 expression, decrease NF-κB expression, repair mitochondrial damage, and improve the degree of chondrocyte aging.

CONCLUSION:

We concluded that the GPNMB/Nrf2/NF-κB signaling pathway plays an important role in chondrocyte senescence and that QZT was able to reduce intracellular oxidative stress and restore impaired mitochondrial function by regulating the expression level of the GPNMB/Nrf2/NF-κB signaling pathway, reducing the level of chondrocyte senescence in the KOA process.

01 Jan 2025·JOURNAL OF ETHNOPHARMACOLOGY

A mathematical multiple-dimensional strategy for Q-markers identification based on “five principles”: Tianshu Capsule for migraine treatment as an example

Article

Author: Feng, Yunhua ; Ju, Wenzheng ; Li, Zhenyang ; Hu, Yu ; Xie, Kaicheng ; Xu, Meijuan ; Zou, Jiandong ; Ma, Chengyao ; Shang, Juan ; Gu, Xiao

ETHNOPHARMACOLOGICAL RELEVANCE:

Quality control is a critical element for Traditional Chinese medicine (TCM). Due to the varied chemical components, mechanisms of action, and pharmacological functions in TCM, ensuring quality is more challenging compared to chemical drugs. Then, the concept of quality markers (Q-markers) was proposed and ideal Q-markers for TCM prescriptions need to compliant with "five principles", including pharmacological effectiveness, specificity, transfer and traceability, measurability, and prescription compatibility.

AIM OF THE STUDY:

To establish a mathematical multiple-dimensional "spider-web" strategy and identify the Q-markers of Tianshu capsule (TSC), a Chinese patent medicine for the treatment of migraine, following the "five principles" rules.

MATERIALS AND METHODS:

Q-marker candidates of TSC were firstly screened according to the HPLC fingerprints. Their contents in 10 batches of TSC and stabilities under high temperature, high humidity and in work solutions were determined quantitatively by HPLC-UV (measurability). Their existences in Gastrodiae Rhizoma, Chuanxiong Rhizoma, TSC, rat plasma and brain samples were investigated using HPLC-Q-TOF/MS (transfer and traceability). Their anti-migraine efficacies were evaluated by network pharmacology and mice hot-plate analgesia test; and their relationships with the property (flavor) of Gastrodiae Rhizoma or Chuanxiong Rhizoma were studied by molecular docking (effectiveness). Their contributions were defined based on their herb source according to the compatibility theories of Da Chuan Xiong Fang (compatibility). Their biosynthetic pathways were studied, and their frequencies detected in different plant families were calculated (specificity). Finally, an eight dimensional "spider-web" mode was developed for 10 components, and the regression area (RA) and the coefficient variation (CV) of each candidate were calculated after data normalization.

RESULTS:

Ten components including gastrodin, parishin E, chlorogenic acid, ferulic acid, isochlorogenic acid A, senkyunolide I, H, A, Z-ligustilide and levistilide A were selected and evaluated as the Q-marker candidates. The results showed that gastrodin, senkyunolide I, and senkyunolide A had the higher RA and lower CV than other compounds with the established "spider-web" mode, indicating that they could be used as the Q-markers of TSC.

CONCLUSION:

The multi-dimensional "spider-web" mode based on "five principles" was firstly applied to identify the Q-markers of TSC, and it can be used as a practical strategy to discover Q-markers of other compounded prescriptions.

News (Medical) associated with Jiangsu Province Hospital of Traditional Chinese Medicine

23 Nov 2022

·www.prnewswire.com

Jiangsu Traditional Chinese Medicine International Exchange Conference kicked off in Nanjing

NANJING, China, Nov. 23, 2022 /PRNewswire/ -- On November 21st, the "Jiangsu Traditional Chinese Medicine International Exchange Conference" jointly sponsored by the Foreign Affairs Office of Jiangsu Provincial People's Government and Jiangsu Health Commission kicked off in Nanjing. The theme of the conference is "Let the World Know Jiangsu Traditional Chinese Medicine", according to the organizing committee. Hu Gang, Vice-Chairman of the Jiangsu Provincial Committee of the CPPCC and President of Nanjing University of Chinese Medicine (NJUCM), said in his speech that Chinese medicine is the treasure of ancient Chinese science and the key to the treasure house of Chinese civilization. Jiangsu TCM International Exchange Conference is a powerful measure to link domestic and international markets and resources, and expand the international influence of Jiangsu Traditional Chinese Medicine, which provides new thinking and direction for Chinese medicine to serve the global health cause. Dr. Mary Faria, President & CEO of AOMA Graduate School of Integrative Medicine, said in a video speech that AOMA Graduate School of Integrative Medicine has established a good cooperative partnership with the Foreign Affairs Office of Jiangsu Provincial People's Government, Jiangsu Province Hospital of Chinese Medicine and NJUCM. Through joint efforts to build Jiangsu Overseas Qihuang Talent Training Project, international talents of traditional Chinese medicine have been trained, sincere humanities exchanges have been promoted, the spread of traditional Chinese medicine around the world has been promoted, and deep friendship has been established. It is hoped that all sides will work together to build a platform for international exchanges and cooperation of traditional Chinese medicine and promote deeper exchanges and cooperation between China and the United States in the field of health care. During the opening ceremony, the icon of Jiangsu TCM, the little Shennong, was launched. The world premiere ceremony of the first Chinese and English version of Chinese medicine comic book Little Shennong's Herbal Adventure in China was held; the collection of overseas book donation activities of Little Shennong's Herbal Adventure was broadcast; the awarding ceremony of the Feeling the Pulse of TCM with Z Generation English short video contest for exploring Chinese medicine was held; NJUCM and Mae Fah Luang University, Sunsuria Group of Malaysia and Instituto Piaget held the signing ceremony of TCM "going global" projects. NJUCM, the national "Double First-class" discipline construction university, as the core strength in Jiangsu Provincial Chinese Medicine development, has been in the forefront of facilitating the internationalization of Chinese medicine. Over the last sixty plus years, NJUCM with its affiliated hospitals has trained more than 30,000 international students. NJUCM world-renowned alumni include "The Father of European Chinese Medicine" Giovanni Maciocia, "The Father of Australian Chinese Medicine Legalization" Lin Tzi-Chiang, etc. NJUCM has established two Confucius Institutes for Traditional Chinese Medicine and eight overseas Chinese Medicine Centers. It has been designated as WHO Collaborating Center for Traditional Chinese Medicine for ten terms consecutively. The university has been selected as the first batch of National Base of Chinese Medicine Service Trade, and has established "Belt and Road" Chinese Medicine International Collaboration Base. It has the Chinese medicine clinics that have been the first to get the ISO 9001 certification. NJUCM has contributed greatly in facilitating Chinese medicine into the mainstream medical education system in Europe, and has dedicated to bringing health and well-being to people all over the world by using the advantages of traditional Chinese medicine. SOURCE The Organizing Committee of Jiangsu Traditional Chinese Medicine International Exchange Conference

100 Deals associated with Jiangsu Province Hospital of Traditional Chinese Medicine

100 Translational Medicine associated with Jiangsu Province Hospital of Traditional Chinese Medicine

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Drug(Targets)	Indications	Global Highest Phase

Changkang Granules	Irritable bowel syndrome with diarrhea More	Phase 3
Tongchuanqing Granules	Asthma More	Phase 3
Langqing A'ta Granules	Fibrosis, Liver More	Phase 2
AC-591	Peripheral Nervous System Diseases More	Phase 2
Qiwei Guibao Granules	Ovarian Insufficiency More	Phase 2

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