Hunan University of Chinese Medicine

The exact psychopathological mechanisms are still poorly understood, despite depression being strongly linked to suicidal acts. Potential differential mediators of suicidal acts in emerging dimensional insights include the internalizing-externalizing spectrum, with neuroticism and impulsivity as core features. Notwithstanding these findings, inquiries persist concerning: (1) their causal specificity versus synergistic effects, (2) the underlying neurobiological implications, and (3) the potential for clinical translation. Our study addresses these gaps through an innovative multi-method framework integrating.

A best-evidence synthesis of 28 studies was performed to evaluate observational associations. Then we analyzed genome-wide association summary data (neuroticism N = 274,108; impulsivity N = 1534; depression N = 499,799; suicidal acts N = 218,792) via Mendelian Randomization (MR) to investigate whether genetically predicted personality mediated the depression to suicidal acts. The Allen Human Brain Atlas was employed to perform gene enrichment analysis.

The observational synthesis found strong evidence that neuroticism was linked to depression to suicidal acts, while impulsivity findings were inconclusive. MR also found that neuroticism significantly mediated the depression to suicidal acts relationship (OR = 1.162, 95 % CI = 1.095-1.233; p < 0.001), while impulsivity showed no causal effect (OR = 0.999, 95 % CI = 0.949-1.052; p = 0.975). Brain-specific gene enrichment analysis showed depression to suicidal acts was enriched in the substantia nigra (p = 0.038, corrected), implicating dopaminergic dysfunction.

This integrative study demonstrates that neuroticism, but not impulsivity, causally mediates suicidal acts in depression, with dopaminergic pathways as a plausible neural substrate. Through this research, we propose personality-specific interventions targeting internalizing traits and high-risk patients with nigro-related dysfunction.

The association between dietary energy intake and disease outcomes in CKD 3-5 remains unclear. This study explored this relationship in Southern Chinese CKD 3-5 patients.

This retrospective cohort study included 234 CKD 3-5 patients from the Self-Management Program for Patients with Chronic Kidney Disease (SMP-CKD) database. The endpoint was a composite of sustained decline of at least 30% in estimated glomerular filtration rate (eGFR), the initiation of kidney replacement therapy, or all-cause mortality. The main variable was energy intake. Kaplan-Meier analysis, restricted cubic splines, and Cox regression models were performed to assess the association.

85 (36.3%) individuals reached the endpoint with a median follow-up of 33 months. The median age was 56.0 (46.3, 63.3) years, and 121 (51.7%) were male. The association between energy intake and the endpoint in CKD 3-5 patients showed a U-shaped relationship. We reclassified patients according to energy intake: Group 1 (<24.6 kcal/kg/d), Group 2 (24.6-29.5 kcal/kg/d), and Group 3 (>29.5 kcal/kg/d). Compared to Group 2, Group 3 (HR = 3.0; 95%CI, 1.118-7.993, p = 0.029) and Group 1 (HR = 2.5; 95%CI, 1.068-5.966, p = 0.035) had a higher risk of reaching the endpoint. Subgroup analysis showed no significant interaction except for age, with a consistent U-shaped relationship in those ≤ 60 years.

High and low energy intake are significantly associated with an increased risk of adverse outcomes in non-dialysis CKD 3-5 patients. An energy intake of 24.6-29.5 kcal/kg/day may be optimal to reduce the risk of poor health outcomes.

Over the last two decades, bioelectrical impedance analysis (BIA) has gained popularity as a method for assessing body compartments in nutrition studies, sports medicine, and evaluating hydration levels, fat mass, and fat-free mass variations in both healthy and diseased individuals. This study aims to offer researchers an overview of the research trends in BIA.

The data was obtained from the Web of Science Core Collection database. Bibliometric analysis was conducted using a package of R software (Bibliometrix 4.0).

A total of 9471 articles have been published over the past 20 years, with an average annual growth rate of 10.1%. The research field primarily focuses on nutrition and dietetics, followed urology and nephrology, endocrinology and metabolism, general and internal medicine, engineering, geriatrics and gerontology, sport sciences, cardiovascular system and cardiology, physiology and science and technology-other topics. The research hotspots of BIA over the past 20 years have transitioned from "water" to "fat," and subsequently to "sarcopenia." "Sarcopenia" and "phase angle" (PhA) have emerged as recent research hotspots in the field of BIA.

A total of 9471 articles have been published over the past 20 years, with an average annual growth rate of 10.1%. Nutrition and dietetics have consistently been the primary research areas in the field of BIA. "Sarcopenia" and "PhA" have emerged as recent research hotspots in the field of BIA. The application of BIA in clinical practice still holds significant untapped potential.