Beijing Merson Pharmaceutical Co. Ltd.

Primary objective: To evaluate the efficacy and safety of topical timolol maleate gel in the treatment of superficial infantile hemangioma at the proliferative stage. Secondary objective: To evaluate the pharmacokinetic characteristics of topical timolol maleate gel in the treatment of superficial infantile hemangioma at the proliferative stage.

Primary objective: To evaluate the safety and tolerability of different application doses of 0.5% timolol maleate gel in children with superficial infantile hemangioma in the proliferative stage. Secondary objective: To evaluate the systemic pharmacokinetic characteristics of 0.5% timolol maleate gel in children with superficial infantile hemangioma in the proliferative stage. Exploratory clinical trial: To preliminarily explore the efficacy of different dosages of 0.5% timolol maleate gel in children with superficial infantile hemangioma in the proliferative stage.

Primary objective: To evaluate the safety and tolerability of timolol maleate gel in healthy Chinese adult volunteers, and to provide a safety basis for determining the drug dose used in later trials. Secondary objective: To evaluate the pharmacokinetic (PK) characteristics of timolol maleate gel in healthy Chinese adult volunteers.