Duoduo Pharmaceutical Co. Ltd.

To study the pharmacokinetics of the test preparation Sitagliptin Metformin Tablets (II) (Specification: 50mg/850mg (based on sitagliptin/metformin hydrochloride), produced by Duoduo Pharmaceutical Co., Ltd.) and the reference preparation Sitagliptin Metformin Tablets (II) (Trade name: JANUMET®/Janoda®, Specification: 50mg/850mg (based on sitagliptin/metformin hydrochloride), licensee: MSD Merck Sharp & Dohme AG) in healthy adult subjects after a single oral administration in fasting and postprandial states, and to evaluate the bioequivalence of the two preparations when taken orally in fasting and postprandial states. Secondary objective: To study the safety of the test preparation Sitagliptin Metformin Tablets (II) and the reference preparation Sitagliptin Metformin Tablets (II) in healthy adult subjects.

Main purpose of the study To study the pharmacokinetics of a single oral dose of the test preparation ilaprazole enteric-coated tablets (specification: 5 mg, produced by Shandong Yaoshi Pharmaceutical Co., Ltd.) and the reference preparation ilaprazole enteric-coated tablets (trade name: Yilian; specification: 5 mg; produced by Livzon Pharmaceutical Factory of Livzon Group) in healthy participants in the fasting/postprandial state, and to evaluate the bioequivalence of the two preparations in the fasting/postprandial state. Secondary purpose of the study To evaluate the safety of the test preparation ilaprazole enteric-coated tablets (specification: 5 mg) and the reference preparation ilaprazole enteric-coated tablets (trade name: Yilian, specification: 5 mg) in healthy participants.

Primary objective: To evaluate the bioequivalence of the two preparations in Chinese healthy subjects in the fasting and fed state, using febuxostat tablets (trade name: Feburic®, specification: 40 mg) from Teijin Pharma Limited as the reference preparation and febuxostat tablets (40 mg) developed by Duoduo Pharmaceutical Co., Ltd. as the test preparation. Secondary objective: To observe the safety of the test preparation and the reference preparation in Chinese healthy subjects.